Clinical trials: Surgical Resection
Liver Neoplasms
Seocalcitol Versus Placebo in the Adjuvant Treatment of Hepatocellular Carcinoma
To evaluate the efficacy of Seocalcitol in prolonging time to relapse following intended curative resection or percutaneous ablative treatment, i.e.
- Trial name
- NCT00051545
- Testing
- Seocalcitol
- Where
- 5 sites in Canada, France and 3 more
- Volunteers
- 608 people
- Sponsor
- LEO Pharma
Rectal Cancer
The Longitudinal Study of Low Anterior Resection Syndrome in Patients with Newly Diagnosed Rectal Cancer.
The aims are to identify the trajectory of LAR Syndrome and explore the adaptation process and coping strategies of LAR Syndrome in patients newly diagnosed with rectal cancer.
- Trial name
- NCT05445245
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- Chang Gung Memorial Hospital
Breast Cancer
Limonene Study in Women With Breast Cancer
Limonene is a major component in the essential oils of citrus fruits. It has demonstrated promising breast cancer preventive and therapeutic effects in preclinical model systems.
- Trial name
- NCT01046929
- Testing
- limonene
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Arizona
Non-small Cell Lung Cancer
Study of Pembrolizumab (MK-3475) vs Placebo for Participants With Non-small Cell Lung Cancer After Resection With or Without Standard Adjuvant Therapy (MK-3475-091/KEYNOTE-091)
In this study, participants with Stage IB/II-IIIA non-small cell lung cancer (NSCLC) who have undergone surgical resection (lobectomy or pneumonectomy) with or without adjuvant chemotherapy will be treated with pembrolizumab or…
- Trial name
- PEARLS (NCT02504372)
- Testing
- Pembrolizumab
- Volunteers
- 1,177 people
- Sponsor
- Merck Sharp & Dohme LLC
Tracheal Stenosis
Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision
Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe.
- Trial name
- NCT07463742
- Testing
- Bronchoscopy, carbon dioxide (CO2) laser wedge resection, Radial incision with dilation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Urinary Bladder Cancer
Intravesical Gem/Doce in Patients With NMIBC
Intravesical immunotherapy or chemotherapy for non-muscle invasive bladder cancer (NMIBC) is a well-established treatment for preventing or delaying tumor recurrence after tumor resection.
- Trial name
- NCT05644041
- Testing
- gemcitabine + docetaxel
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Arizona
BPH With Urinary Obstruction, Male
HoLEP vs BPRP in the Management of a Large Volume (> 80 gm) Symptomatic BPH
To compare bipolar resection versus holmium laser enucleation for management of symptomatic large BPH (> 80 gm)
- Trial name
- NCT04935151
- Testing
- holmium laser enucleation of the prostate, Bipolar resection of the prostate
- Where
- 2 sites in Egypt
- Volunteers
- 112 people
- Sponsor
- Cairo University
Recurrent High-Grade Gliomas, Brain Neoplasm
A Study of SRN-101 Administered Prior to Surgical Resection in Adults With Recurrent High-Grade Glioma.
SRN-101 is designed to destroys tumor cells while simultaneously activating the immune system to fight cancer. This is a first in human, single arm study to evaluate SRN-101 for the treatment of adults with recurrent high-grade…
- Conditions
- Recurrent High-Grade Gliomas, Brain Neoplasm, Glioma
- Trial name
- NCT07826949
- Testing
- SRN-101, Blood Specimen Collection, Surgical Resection
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Nicholas Butowski
Older Adults, Anxiety
Behavioral Activation and Medication Optimization for Perioperative Mental Health Feasibility Study
Inadequate management of preoperative mental health disorders often contributes to poor postoperative outcomes, including increased rates of readmission, delirium, falls, and mortality.
- Conditions
- Older Adults, Anxiety, Depression, Cardiac Surgery
- Trial name
- NCT05110690
- Testing
- Behavioral Activation, Medication Optimization
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Washington University School of Medicine
Rectal Diseases, Sigmoid Colon Disease, Rectal Cancer, Sigmoid Colon Cancer
Extra-Peritoneal Tunneling Versus Conventional Drain Fixation After Anterior or Low Anterior Resection
The goal of this clinical trial is to learn whether the extra-peritoneal tunneling (EPT) drain fixation method works better and more safely than the conventional drain insertion method after rectal cancer surgery.
- Trial name
- ExPeTuD (NCT07241143)
- Testing
- EPT drain fixation, Conventional drain insertion
- Where
- South Korea
- Volunteers
- 596 people
- Sponsor
- Yeungnam University Hospital
Renal Cell Carcinoma Stage III
Renal Cell Carcinoma and Stage IV Inferior Vena Cava Thrombus: Resection Without Thoracotomy
Assessment of short-term outcomes of radical nephrectomy combined with IVC thrombectomy with a novel technique without thoracotomy: single center case series.
- Trial name
- NCT04350047
- Testing
- Radical nephrectomy with inferior vena cava thrombectomy without thoracotomy
- Where
- Greece
- Volunteers
- 3 people
- Sponsor
- Attikon Hospital
Crohn Disease, Recurrence
Mesentery Guide Identify Microscopic Clean Resection and Reduces Crohn's Endoscopic Recurrence
Microscopic clean margin is associated with reduced endoscopic recurrence after bowel resection for ileocolic Crohn's disease (CD).
- Trial name
- NCT06550843
- Testing
- mesentery-guided division
- Volunteers
- 150 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Low Anterior Resection Syndrome, Rectal Cancer
Transanal Irrigation for the Management of LARS
This study aims to evaluate the impact of Transanal irrigation (TAI) on the quality of life and low anterior resection symptoms (LARS) in Canadian rectal cancer survivors living with minor to major LARS.
- Trial name
- TAI-LARS (NCT05007015)
- Testing
- Transanal Irrigation
- Where
- 8 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Jewish General Hospital
Rectal Cancer
APEMESH II - Perineal Reconstruction
The objective of this pilot study is to assess the safety, functional outcome, feasibility and the potential benefits of synthetic mesh strip and gluteus flap reconstruction in perineum in case-control setting.
- Trial name
- NCT04779125
- Testing
- Gluteus plasty enhanced with Progrip self gripping mesh
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Oulu
Benign Prostatic Hyperplasia
Acute Hemostasis Following the Use of the AQUABEAM® System for the Treatment of Benign Prostatic Hyperplasia II
A single-arm prospective, interventional clinical trial to evaluate the safety and performance of obtaining hemostasis following prostate resection using the AQUABEAM for treatment of LUTS resulting from BPH.
- Trial name
- AHA II (NCT03125889)
- Testing
- AquaBeam System
- Where
- India
- Volunteers
- 11 people
- Sponsor
- PROCEPT BioRobotics
Head and Neck Cancer
A Study of Erlotinib (Tarceva) in Participants With Resected Head and Neck Squamous Cell Cancer
This two-arm study will compare the efficacy and safety of erlotinib (Tarceva) versus placebo in participants with resected head and neck squamous cell cancer who are receiving concurrent chemoradiotherapy or radiotherapy alone.
- Trial name
- NCT00412217
- Testing
- Erlotinib, Standard of care
- Where
- 31 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Hoffmann-La Roche
Benign Prostatic Hyperplasia
Prostate Artery Embolization With Embosphere Microspheres Compared to TURP for Benign Prostatic Hyperplasia
The purpose of this study is to evaluate improvement of symptoms from benign prostatic hyperplasia (BPH) as assessed by the International Prostate Symptom Score (IPSS) for prostatic artery embolization (PAE) using Embosphere…
- Trial name
- NCT01789840
- Testing
- Embosphere Microspheres, TURP
- Where
- 10 sites in United States
- Volunteers
- 59 people
- Sponsor
- Merit Medical Systems, Inc.
Colorectal Cancer, Rectal Tumors
Reconstruction Techniques and Vascular Approach After Laparoscopic Left Hemicolectomy and Rectum Low Anterior Resection
This is an interventional, controlled and randomized single-center clinical trial with patients diagnosed with colorectal cancer that will undergo laparoscopic left hemicolectomy or laparoscopic low anterior resection for rectal…
- Trial name
- TAHR (NCT02746224)
- Testing
- Initially dissection of inferior mesenteric vein, Initially dissection of inferior mesenteric artery, Latero-terminal colorectal anastomosis
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Congenital Lung Malformation
Early Outcomes of Thoracoscopic Anatomical Lesion Resection for Congenital Lung Malformations in Children: A Single-Center Experience in a Limited-Resource Country
This study aimed to evaluate the safety and efficacy of thoracoscopic resection for CLMs in pediatric patients.
- Trial name
- NCT07859774
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Colorectal Cancer
Endoscopic Treatment for Local Residual Neoplasia
Endoscopic mucosal resection (EMR) is considered to be a gold standard of therapy of colorectal lateral spreading tumors (LST) without significant risk for lymphatic spread.
- Trial name
- NCT02386618
- Testing
- Standardized endoscopic treatment of local residual neoplasia
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Vitkovice Hospital
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