Clinical trials: Surgical Resection
Hepatocellular Carcinoma (HCC)
Sintilimab Combined With Bevacizumab Biosimilar as Adjuvant Treatment After Resection of Ruptured Hepatocellular Carcinoma (CLEAR-2)
Primary liver cancer-particularly hepatocellular carcinoma (HCC)-remains a major health burden in China, characterized by high incidence and mortality rates and poor 5-year survival.
- Trial name
- NCT07331883
- Testing
- Sintilimab plus bevacizumab biosimilar
- Where
- 4 sites in China
- Volunteers
- 35 people
- Sponsor
- Ruijin Hospital
Pain Control After Elective Hepatectomy
Epidural Versus Paravertebral Block Analgesia After Hepatectomy
The best mode of analgesia delivery after hepatectomy is currently unknown. Many institutions routinely use continuous epidural analgesia (CEA) for pain control in this patient population.
- Trial name
- NCT02909322
- Testing
- Bupivacaine and Hydromorphone, Ropivacaine and Hydromorphone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Anthony Ho
Chronic Tonsillitis
Study Comparing Harmonic Scalpel and Conventional Cold Steel Tonsil Removal Surgery in Children Requiring Tonsillectomy
This clinical trial aims to compare two commonly used methods of tonsil removal surgery (tonsillectomy) in children and adults with chronic tonsillitis.
- Trial name
- NCT07656831
- Testing
- Cold Steel Dissection Tonsillectomy, Harmonic Scalpel Tonsillectomy
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Allama Iqbal Teaching Hospital
Rectal Cancer, Pelvic Cancer
Advanced Pelvic Surgical Oncology Database - Prospective Observational Study
Retrospective and prospective observational study of patients undergoing advanced pelvic oncological resection for maligancy including multi visceral resection, beyond TME resection and sacrectomy/flap reconstruction/urinary…
- Conditions
- Rectal Cancer, Pelvic Cancer, Gynecologic Cancer, Colon Cancer
- Trial name
- NCT05696002
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Glasgow Royal Infirmary
Liver Cancer, Adult
Analgesia by Transversus Abdominis Plane Nerve Block in Patients Undergoing Liver Resection.
The indications liver cancer surgery currently booming due to the increase in surgical techniques and instruments for a more secure resection of liver tissue with a significant reduction in bleeding or surgical complications.
- Trial name
- BLOC-TAP (NCT02527577)
- Testing
- RopivacaIne chlorhydrate
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pancreatic Cancer
A Study of Durvalumab in Patients With BR PDA Following Neoadjuvant Therapy and Successful Surgical Resection
This is a two-arm, open-label, phase II study of in adult patients who have successfully undergone R0/R1 resection of PDAs following neoadjuvant chemotherapy and completion of adjuvant chemotherapy.
- Trial name
- NCT03038477
- Testing
- Durvalumab
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Liver Tumours, Liver Cancer (Primary and Metastatic)
Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy
The goal of this national mutlticenter observational study is to learn and describe trends over time in the use of techniques for inducing hepatic hypertrophy in Italy.
- Conditions
- Liver Tumours, Liver Cancer (Primary and Metastatic), Liver Resection, Liver Hypertrophy
- Trial name
- I-GROWtoh (NCT07445412)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pedunculated Colorectal Polyps, Haemorrhage
Cold Snare Polypectomy Versus Hot Snare Polypectomy for Resection of Small Pedunculated Polyps
Endoscopic resection of pedunculated polyps mainly focuses on how to prevent bleeding, and also needs to pay attention to the convenience of resection and the integrity of resection, which means that different endoscopic…
- Trial name
- NCT06097650
- Testing
- cold snare polypectomy, hot snare polypectomy
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Ningbo No. 1 Hospital
Acute Abdomen, Emergency Surgery
Primary Cecal Pathologies Presenting as Acute Abdomen
Background: The importance of cecal pathologies lie in the fact that being the first part of large intestine, any disease involving the cecum affects overall functioning of the large bowel.
- Conditions
- Acute Abdomen, Emergency Surgery, Laparotomy, Amoebic Colitis
- Trial name
- NCT03262025
- Testing
- Operated
- Volunteers
- 43 people
- Sponsor
- Jawaharlal Nehru Medical College
Postoperative Complications
Effect of Daytime Variation on PPCs in Lung Resection Surgery.
The aim of this retrospective study was to evaluate the association between daytime variation in surgery start time and the occurrence of postoperative pulmonary complications (PPCs) and postoperative adverse events (AEs) in…
- Trial name
- NCT05582291
- Where
- China
- Volunteers
- 1,138 people
- Sponsor
- Qianfoshan Hospital
Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma
Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma
This phase III trial compares chest computed tomography (CT) to chest x-ray (CXR) for lung surveillance after curative-intent resection of high-risk truncal-extremity soft tissue sarcoma.
- Conditions
- Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma, AJCC Grade 3 Sarcoma, Alveolar Soft Part Sarcoma
- Trial name
- NCT06526897
- Testing
- Biopsy, Chest Computed Tomography, Chest Radiography
- Volunteers
- 1,582 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Colorectal Disorders
Prospective Database for Colonic or Rectal Resection Surgery Patients
Colorectal cancer is the third most common cancer in men, after prostate and lung cancer. It represents 11.2% of all new cases of male cancer.
- Trial name
- CHIRCOLREC (NCT04704817)
- Testing
- obsevation
- Volunteers
- 1,000 people
- Sponsor
- Institut Paoli-Calmettes
Brain Metastases From Solid Tumors
131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiation in Patients With Multiple Brain Metastases From Solid Tumors
The aim of this Proof of Concept study is to determine the therapeutic potential of the L19SIP antibody, labeled with the radionuclide 131I in combination with external beam radiation, for the treatment of patients with multiple…
- Trial name
- NCT01125085
- Testing
- 131I-L19SIP Radioimmunotherapy (RIT) in Combination With Whole Brain Radiation Therapy (WBRT)
- Where
- 10 sites in Italy, United Kingdom
- Volunteers
- 32 people
- Sponsor
- Philogen S.p.A.
Chronic Hepatitis b, Hepatic Carcinoma
The Investigation of Peginterferon Alfa-2a on the RFS of the Subjects With HCC Who Have Been Treated by Resection
The current study is a prospective, randomized, open, multi-center investigation. The aim of current study is to investigate whether the Recurrence-free Survival Rate (RFS）of the hepatitis B related -hepatocellular carcinoma…
- Trial name
- NCT03253250
- Testing
- ETV；TDF；ADV, Peginterferon Alfa-2a
- Where
- China
- Volunteers
- 432 people
- Sponsor
- Huashan Hospital
Surgery, Eye Diseases
Self-adherent Wrap Techniques for Orbital Surgery
The purpose of this study is to evaluate the interface pressure measurements of applying self-adherent wraps on eyes after orbital tumour extirpation.
- Trial name
- NCT03415490
- Testing
- Folded technique of self-adherent wrap, Classic technique of self-adherent wrap
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Sun Yat-sen University
Cancer Colorectal
ctDNA Methylation Application in Postoperative Relapse and Adjuvant Chemotherapy Efficacy Evaluation
In this study, the investigators aimed to apply their previously developed multi-locus blood-based assay targeting circulating tumor DNA methylation to monitor postoperative relapse and evaluate adjuvant chemotherapy efficacy in…
- Trial name
- NCT05536089
- Testing
- a multi-locus blood-based assay
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Singlera Genomics Inc.
Metastatic Colorectal Cancer
A Study With Neoadjuvant mFOLFOX7 Plus Cetuximab to Determine the Surgical Conversion Rate for Unresectable Colorectal Cancer With Metastases Confined to the Liver
FC-6 is a Phase II, multi-center clinical trial for patients with unresectable, wild-type K-RAS, colorectal cancer with metastases confined to the liver.
- Trial name
- NCT00803647
- Testing
- cetuximab, 5-FU, oxaliplatin
- Where
- 23 sites in United States
- Volunteers
- 20 people
- Sponsor
- NSABP Foundation Inc
Non-Small Cell Lung Cancer (NSCLC), Clinical Staging T2b-3 N0-1 M0
--SuPERIOR Trial--
The Window-of-Opportunity (WOO) Network is a collaboration among Ontario's doctors and scientists to conduct clinical trials in newly-diagnosed cancer patients before they have surgery with an initial focus on understanding how…
- Trial name
- NCT06191250
- Testing
- Durvalumab, Non-ablative oligofractionated radiation (NORT)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Gastric Cancer, Adjuvant Chemotherapy, XO
Compare Adjuvant Chemotherapy of Docetaxel/Capecitabine/Oxliplatin Versus Capecitabine/Oxaliplatin in Advanced Gastric Cancer at Stage IIIb and IV(KCSG ST15-08): TRIUMPH
multicenter, open label, randomaized, phase III The role of post surgery adjuvant chemotherapy is becoming more and more important in AGC (advance gastric cancer).
- Trial name
- NCT01935778
- Testing
- Docetaxel and capecitabine and oxaliplatin, capecitabine and oxaliplatin
- Where
- South Korea
- Volunteers
- 286 people
- Sponsor
- Asan Medical Center
Breast Neoplasms, Carcinoma, Ductal, Breast
Study of Autologous Fat Enhanced w/ Regenerative Cells Transplanted to Reconstruct Breast Deformities After Lumpectomy
A post-marketing study evaluating the transplantation of autologous fat augmented with Adipose Derived Regenerative Cells (ADRCs), in patients with functional and cosmetic breast deformities post segmental mastectomy or…
- Conditions
- Breast Neoplasms, Carcinoma, Ductal, Breast, Mammaplasty, Mastectomy, Segmental, Lumpectomy, Breast Reconstruction,
- Trial name
- RESTORE-2 (NCT00616135)
- Testing
- ADRC-Enhanced Autologous Fat Transplant
- Where
- 5 sites in Belgium, Italy and 2 more
- Volunteers
- 71 people
- Sponsor
- Cytori Therapeutics
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