Clinical trials: Surgical Site Infection
Post Operative Pain, Appendicitis
Evaluation of Local Anesthetic at Incision Site
Patient will have usual appendectomy surgery with an injection of local or saline at incision site either before or after the incision at random.
- Trial name
- NCT02483689
- Testing
- Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- NCT04618276
- Testing
- Photodynamic Therapy
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Surgical Site Infection
Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery
A prospective, randomized study was performed. The patients were randomized into 2 groups: those patients undergoing subcutaneous vitamin E ointment application (Group 1) and those patients who not (Group 2).
- Trial name
- NCT02820948
- Testing
- Vitamin E ointment application
- Volunteers
- 108 people
- Sponsor
- Hospital General Universitario Elche
Surgical Site Infection (SSI)
Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During CABG Surgeries in Egyptian Patients.
A randomized controlled trial on adults who underwent coronary artery bypass grafting (CABG) surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT)…
- Trial name
- NCT07658378
- Testing
- Cefazolin 2 g Infusion, Cefazolin 2 GM Injection
- Volunteers
- 100 people
- Sponsor
- Helwan University
Surgical Site Infection, Skin Colonization
Dressing Wear Time After Reduction Mammaplasty
This study was designed to determine whether the duration of dressing wear following reduction mammaplasty influence skin colonization and surgical site infections rates.
- Trial name
- NCT01002391
- Testing
- reduction mammaplasty
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Daniela Francescato Veiga
Congenital Heart Diseases, Aortic Valve Disorder
Pre-operative Prophylaxis With Vancomycin and Cefazolin in Pediatric Cardiovascular Surgery Patients
The investigators hope to learn 1) if the addition of prophylaxis with vancomycin will decrease the rate of cefazolin non-susceptible surgical site infections (SSI), in high risk population 2) to develop better understanding of…
- Trial name
- NCT01619982
- Testing
- Cefazolin 25 mg/kg body weight and Vancomycin hydrochloride, Cefazolin 30 mg/kg body weight
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stanford University
Surgical Wound Infection
Trial Investigating Cyanoacrylate Glue to Prevent Surgical Site Infection Following Breast Surgery
Surgical Site Infections (SSI) represents a significant complication in plastic surgery. Infections can result in a prolonged recovery and impair long-term cosmetic appearance.
- Trial name
- NCT02779296
- Testing
- 2-Octyl Cyanoacrylate Glue
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Infection, Surgical Site
Effectiveness and Clinical Application of MolecuLight Bacterial Fluorescence Imaging in Wound Debridement
MolecuLight is a device that utilizes a special light which, when used on wounds, helps identify the regions which pathogenic bacterial counts are the highest.
- Trial name
- NCT04541394
- Testing
- MolecuLight
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Surgical Site Infection
Effect of Barbed Suture and Triclosan-coated Monofilament in Emergency Surgery
Patients will be randomized 3 groups: Group 1: Abdominal fascial closure will be performed with Triclosan-coated barbed Polydioxanone suture Group 2:Abdominal fascial closure will be performed with Triclosan-coated monofilament…
- Trial name
- NCT03763279
- Testing
- Triclosan-coated barbed suture, Triclosan-coated monofilament suture, Monofilament suture
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital General Universitario Elche
Bacterial Infections, Antibiotic Resistant Infection
Antibiotic Profile of Pathogenic Bacteria Isolated in Public Hospitals in Northern Jordan
The main aim of the study was to identify the various pathogens associated with surgical site infections and their antibiotic susceptibility in a governmental hospital in northern Jordan.
- Conditions
- Bacterial Infections, Antibiotic Resistant Infection, Surgical Site Infection
- Trial name
- NCT05106803
- Testing
- ciprofloxacin
- Where
- Jordan
- Volunteers
- 24 people
- Sponsor
- Yarmouk University
Surgical Site Infection
Impact of Pre-surgical Nasal Bacterial Reduction on Postoperative Surgical Site Infections / Standard Care Change
Patients presenting in the Emergency Department or admitted to the hospital with displaced hip fractures who require hemiarthroplasty or open reduction internal fixation or with spinal instability/fractures in need of urgent…
- Trial name
- NCT01148030
- Testing
- 3M Skin and Nasal Antiseptic
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- 3M
Thoracic Diseases, Thoracic Neoplasms
Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.
The goal of this RCT is to compare outcome with McGrath vs Macintosh laryngoscopes among patients undergoing thoracic surgery. The main questions it aims to answer are, 1. Rate of successful intubation at first attempt and 2.
- Conditions
- Thoracic Diseases, Thoracic Neoplasms, Thoracic Empyema
- Trial name
- NCT05988736
- Testing
- MaCintosh Laryngoscope (DL), McGrath Laryngoscope (VL)
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Aga Khan University
Perioperative Hyperoxygenation, Wound Infection
Effect of Peri-operative Supplemental Oxygen in Wound Infection After Appendectomy
The study evaluates the role of supplemental hyper-oxygenation given perioperatively on wound site infection after appendectomy.
- Trial name
- NCT02687217
- Testing
- oxygen
- Volunteers
- 60 people
- Sponsor
- Lady Hardinge Medical College
Tissue Expander Based Breast Reconstruction
Local Antibiotic Concentrations With Tissue Expanders in Breast Reconstruction
Infections after tissue expander breast reconstruction can lead to pain, additional surgeries, and loss of the reconstruction. This study will compare two types of antibiotic carriers used during surgery to help lower the risk of…
- Trial name
- NCT07339215
- Testing
- Antibiotic loaded calcium sulfate beads, Polymethylmethacrylate antibiotic disc
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Ankle Fractures
Factors Influencing the Risk of Surgical Site Infections and Wound Complications in Operatively Treated Ankle Fractures in the Elderly
This study is to analyse risk factors for wound complications or surgical site infections and to analyse whether risk factors for wound complications or surgical site infections are also factors for other complications.
- Trial name
- NCT04379791
- Testing
- Data collection from routine medical records
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Staphylococcus Aureus, Surgical Wound Infection
Advanced Understanding of Staphylococcus Aureus Infections in Europe - Surgical Site Infections
ASPIRE-SSI is a prospective, observational, multicentre cohort study among adult surgical patients, which aims to determine the incidence of healthcare-associated S. aureus infections, particularly S.
- Trial name
- ASPIRE-SSI (NCT02935244)
- Where
- 33 sites in Belgium, Czechia and 8 more
- Volunteers
- 5,004 people
- Sponsor
- UMC Utrecht
Emergency Surgery, Surgical Site Infections
Irrisept in Emergency General Surgery Patients
This is a single institution, randomized study conducted to determine if irrigation with Irrisept in emergency general surgery patients results in lower surgical site infections compared to normal saline irrigation.
- Trial name
- NCT07048899
- Testing
- Chlorhexidine, Normal Saline
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Health Science Center at Tyler
Surgical Site Infection
Use of 2% Chlorhexidine Cloths Reduce Surgical Site Infections
Use of 2% chlorhexidine gluconate cloths pre-operatively and daily post-operatively jaw line to toes will decrease surgical site infections (SSI) by 30% when compared to patients who receive routine standard of care (use of…
- Trial name
- NCT02385708
- Testing
- 2% Chlorohexidine Gluconate Standard of Care, 2% Chlorohexidine Gluconate Chin to Toe
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Vanderbilt University
Abdominal Aortic Aneurysm, Morbid Obesity
Pilot Study on the Effectiveness and Safety of OPTILENE® SILVER MESH ELASTIC in Prevention of Surgical Site Infection (SSI) and Incisional Hernia (IH)
The aim of the study is to describe the effectiveness of Optilene® Silver Mesh Elastic on prevention of surgical site infection (SSI) at 6 months follow-up in patients undergoing urgent laparotomy by collecting clinical data on…
- Trial name
- SSIHLVER (NCT06547138)
- Testing
- Prophylactic mesh
- Where
- 5 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Aesculap AG
Surgical Site Infections, Surgical Wound Infection
Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections
This is a Phase 3 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major…
- Conditions
- Surgical Site Infections, Surgical Wound Infection, Infections, Anti-Infective Agents
- Trial name
- LANTERN (NCT06702878)
- Testing
- nasal antimicrobial photodisinfection therapy
- Where
- 14 sites in United States
- Volunteers
- 4,787 people
- Sponsor
- Ondine Biomedical Inc.