Clinical trials: Surgical Stress Response
Colorectal Neoplasms
Immunological and Oxidative Stress Response in Relation to Abdominal Cancer Surgery
The aim of this study is to characterize the systemic stress response (SSR) induced in patients undergoing colorectal cancer (CRC) surgery. The project is a clinical prospective study.
- Trial name
- IMOX (NCT03473327)
- Volunteers
- 37 people
- Sponsor
- Zealand University Hospital
Muscle Weakness, Anesthesia
The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response
The effect of surgery, in contrary to critical illness, on muscle weakness hasn't been thoroughly investigated. Recent data suggest that elective surgery may also induce muscle weakness.
- Conditions
- Muscle Weakness, Anesthesia, Anesthesia, Local, Surgery
- Trial name
- MUSCLE (NCT03600454)
- Testing
- General anesthesia, Spinal anesthesia, General anesthesia and epidural analgesia
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Ziekenhuis Oost-Limburg
Fasting, Feeding, Time Restricted
Anabolic Effects of Intraoperative Feeding in Reconstruction Surgery
Perioperative fasting remains a common clinical practice in surgical patients to prevent the development of postoperative anesthesia- and surgical-related complications.
- Conditions
- Fasting, Feeding, Time Restricted, Stress-related Problem, Head and Neck Neoplasms
- Trial name
- NCT04266015
- Testing
- Enteral nutrition formula
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- E-DA Hospital
Coronary Artery Disease, Valvular Heart Disease
The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone
During induction for cardiac surgery, patient hemodynamic stability is achieved by using anesthetic drugs which least affects hemodynamics such as benzodiazepines, etomidate.
- Trial name
- NCT01495949
- Testing
- etomidate, thiopentone
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Mahidol University
Obesity, Bariatric Surgery Candidate
Modulation of the Inflammatory Response in Bariatric Surgery
This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with…
- Conditions
- Obesity, Bariatric Surgery Candidate, Inflammation, Postoperative Pain
- Trial name
- MRICBx3 (NCT06915558)
- Testing
- Opioid-Free Anesthesia (OFA), Opioid-Based Intravenous Anesthesia (OBA-IV), Opioid-Based Inhalational Anesthesia (OBA-Inh)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital HM Nou Delfos
Erector Spinae Plane Block, Systemic Immune-inflammatory Index
Investigation of the Effect of Erector Spinae Plane Block on Systemic Immuno-Inflammatory Index
Erector spinae plane block (ESPB) is a novel interfascial block technique first described by Forero in 2016. It has been reported to be effective in various clinical indications.
- Conditions
- Erector Spinae Plane Block, Systemic Immune-inflammatory Index, Breast Cancer
- Trial name
- NCT06954324
- Testing
- Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Namik Kemal University
Stress Physiology, Staff Work Load
The Intermittent Pneumoperitoneum Scheme of Work Breaks in Complex Laparoscopic Surgery
Many people spanning from air traffic controllers to simple production line workers share regular compulsive breaks to revert fatigue whilst they work.
- Conditions
- Stress Physiology, Staff Work Load, Artificial Pneumoperitoneum, Anuria
- Trial name
- IPP (NCT01009372)
- Testing
- IPP
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Hannover Medical School
General Anesthesia, Laparotomy
Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy
The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was found that nociception and…
- Conditions
- General Anesthesia, Laparotomy, Inflammation
- Trial name
- PRO-Ketamine (NCT04462094)
- Testing
- Ketamine 0.3 mg/kg at end-of-surgery, Ketamine 0.3 mg/kg at anesthesia induction
- Where
- Indonesia
- Volunteers
- 68 people
- Sponsor
- Udayana University
Ultrasound, External Oblique
Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery
This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.
- Conditions
- Ultrasound, External Oblique, Rectus Abdominis Plane Block, Neuroendocrine Stress Response
- Trial name
- NCT07324863
- Testing
- General anesthesia, External oblique and rectus abdominis plane (EXORA) block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Laparoscopic Cholecystectomy Surgery
Attenuate the Stress Response in Laparoscopic Cholecystectomy
Aims of this study are to compare the effectiveness of dexmedetomidine versus fentanyl-midazolam in attenuating hemodynamic stress response during laparoscopic cholecystectomy (mainly HR).
- Trial name
- NCT07425444
- Testing
- Dexmedetomidine, Fentanyl- midazolam
- Volunteers
- 50 people
- Sponsor
- Assiut University
Inflammation, Perioperative Morbidity
The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Non-cardiac Surgery (Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT Trial))
Evidence thus suggests that steroid administration, tight glucose control, and avoidance of deep anesthesia may decrease perioperative morbidity by reducing the inflammatory response to surgery.
- Trial name
- NCT00995501
- Testing
- Dexamethasone Sodium Sulfate, Insulin, anesthesia management
- Where
- United States
- Volunteers
- 381 people
- Sponsor
- d sessler
Opioid Use, Unspecified, Bariatric Surgery Candidate
Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids
The goal of this clinical trial is to compare Opioid Free and Opioid Based Anaesthesia in patients undergoing sleeve gastrectomy.
- Trial name
- NCT05752799
- Testing
- Opioid Free Anaesthesia, Opioid based anesthesia
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- G.Gennimatas General Hospital
Total Intravenous Anesthesia, Inhalational Anesthesia
Intravenous Anesthesia by Targeted Controlled Infusion Versus Inhalational Anesthesia on the Surgical Stress Response
This study aims to compare the effect of total Intravenous anesthesia Target-controlled infusion (TIVA-TCI) with inhalational anesthesia on stress response.
- Conditions
- Total Intravenous Anesthesia, Inhalational Anesthesia, Surgical Stress Response, Target-controlled Infusion
- Trial name
- NCT06024733
- Testing
- Sevoflurane, Target Controlled Infusion, Target Controlled Infusion and lidocaine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Thyroid Cancer, Thyroid and Parathyroid Surgery
The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response
The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of…
- Conditions
- Thyroid Cancer, Thyroid and Parathyroid Surgery, Hyperthyreosis and Goiter, Surgical Stress Response
- Trial name
- NCT07600580
- Testing
- bilateral ultrasound guided intermediate cervical plexus block with 0,25% levobupivacaine
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- University Hospital Dubrava
Diabetes Mellitus Type 2, Insulin Resistance
Modulating the Stress Response in Diabetes Mellitus Type 2 Patients Undergoing Colon Surgery
Background Surgical injury provokes a stress response. These pathways mediated by stress hormones and cytokines cause a catabolic state. The loss of body cell mass may result in prolonged convalescence and increased morbidity.
- Trial name
- NCT02863276
- Testing
- Intensified insulin therapy
- Volunteers
- 18 people
- Sponsor
- University Hospital, Basel, Switzerland
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Stress Response
Effect of Dexmedetomidine on Stress Response and Emergence Agitation During Laparoscopic Surgery
Emergence agitation is a post-anesthetic phenomenon that develops in the early phase of general anesthesia recovery, and is characterized by agitation, confusion, disorientation, and possible violent behavior.
- Trial name
- NCT02917018
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Anesthesia Complication, Anesthesia Intubation Complication
Magnesium Sulfate in Surgical Stress Attenuation Postoperative Sore Throat and Stress Response Induced Tracheal Intubation
Magnesium sulfate has many mechanisms of action for attenuating the stress response as inhibition of catecholamine releasing from the adrenal medulla, keeping the plasma concentration of epinephrine at a fixed level, decreasing…
- Trial name
- Magnesium (NCT06091631)
- Testing
- Magnesium sulfate vaporization
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Systemic Inflammatory Response Syndrome, Posttraumatic Stress Disorder
Influence of Hydrocortisone on Immunologic Markers and Health Care Related Quality of Life in Patients After Cardiac Surgery
Hydrocortisone has been shown to improve the early outcome of high risk patients after cardiac surgery. A potential mechanism resulting in this effect may be its immunomodulatory action.
- Trial name
- NCT00490828
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Abdominal Cancer
Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress
This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on stress response and postoperative pain in lower abdominal cancer surgery.
- Trial name
- NCT02927379
- Testing
- Dexmedetomidine, Ketamine, Bupivacaine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University