Clinical trials: Surgical Treatment for Heart Valve Diseases
Mitral Valve Insufficiency, Mitral Valve Annuloplasty
Study on Surgical Treatment Strategies for Moderate Ischemic Mitral Regurgitation
This study aimed to compare the efficacy of isolated coronary artery bypass grafting and coronary artery bypass grafting + mitral valve repair in moderate ischemic mitral regurgitation patients through a cohort and explore the…
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Annuloplasty, Coronary Artery Bypass
- Trial name
- NCT06408779
- Testing
- mitral valve repair
- Where
- China
- Volunteers
- 464 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Hypertension, Mitral Valve Surgery
PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension
A randomized, placebo controlled, single center clinical trial for evaluation of efficacy and safety of Sildenafil administration in the cardiac ICU following Mitral Valve (MV) Surgery in patients with pre-operative Significant…
- Trial name
- NCT02378649
- Testing
- Sildenafil
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Dr. Robert Klempfner Heart Rehabilitation Institute
Congenital Heart Disease
Autus Valve Pivotal Study
Prospective, single-arm, multi-center study to evaluate safety and effectiveness of the Autus Size-Adjustable Valve in pediatric patients aged 18 months to 16 years requiring surgical pulmonary valve replacement.
- Trial name
- NCT05006404
- Testing
- Pulmonary Valve Replacement Surgery
- Where
- 12 sites in United States
- Volunteers
- 62 people
- Sponsor
- Edwards Lifesciences
Subaortic Stenosis, Congenital Heart Disease
The Fate of Aortic Valve After SAS Surgery in Children
Aortic valve regurgitation (AR) is a common complication following surgery for subaortic stenosis (SAS), yet the long-term outcomes and risk factors for postoperative significant AR (SAR) remain poorly understood.
- Conditions
- Subaortic Stenosis, Congenital Heart Disease, Aortic Regurgitation
- Trial name
- NCT06751368
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cardiac Valve Disease, Coronary Artery Disease
Telehealth Interventions for Cardiac Surgery
The goal of this clinical trial is to compare telehealth monitoring at home against usual care in patients undergoing planned heart surgery. The main questions it aims to answer are: 1.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Surgical Complication
- Trial name
- TICS (NCT05621954)
- Testing
- Telehealth Monitoring
- Where
- United Kingdom
- Volunteers
- 318 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation (AF), Heart Valve Diseases
An Exploratory Clinical Study to Evaluate the Safety and Efficacy of a Cardiac Surgical Cryoablation System for the Treatment of Atrial Fibrillation
The goal of this prospective, observational study is to evaluate the safety and efficacy of a cardiac surgical cryoablation system for the treatment of atrial fibrillation. This study will be conducted at Fuwai Hospital in China.
- Trial name
- NCT06703528
- Testing
- cryoablation
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Congenital Heart Disease, Coarctation of Aorta
An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease
The purpose of this two-way cohort study was to explore whether an integrated prenatal and postnatal treatment model for neonates with critical congenital heart disease (CCHD) could be effective in avoiding preoperative…
- Conditions
- Congenital Heart Disease, Coarctation of Aorta, Aortic Stenosis, Pulmonary Atresia
- Trial name
- NCT06768008
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Mitral Regurgitation
MitraClip® After Surgical Mitral Valve Repair
Percutaneous edge-to-edge repair of the mitral valve has been shown to be a safe and effective alternative treatment option for selected patients at high risk for cardiac surgery.
- Trial name
- MVRepair (NCT02853955)
- Testing
- Percutaneous edge-to-edge repair of the mitral valve
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- LMU Klinikum
Pulmonary Dysfunction, Median Sternotomy Recovery
FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy
Background and Rationale: Open-heart surgery via a median sternotomy is associated with severe acute postoperative pain. This pain can impair a patient's ability to take deep breaths and cough effectively which increases the risk…
- Conditions
- Pulmonary Dysfunction, Median Sternotomy Recovery, Postoperative Pain
- Trial name
- FROST-STERN (NCT07637370)
- Testing
- Intercostal Nerve Cryoablation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
Cardiovascular Disease
A New Operation for the Treatment for Long-standing Atrial Fibrillation
Atrial fibrillation(AF) often occurs in patients with mitral valve disease. Both mitral replacement and mitral valve plasty are the effective methods to the mitral valve disease.
- Trial name
- ANOLAF (NCT03347695)
- Testing
- Left Atrial Geometric Volume Reduction, Pulmonary Vein Island Isolation and Left Appendage Base Closure(selected patients), Left Atrial Geometric Volume Reduction, Pulmonary Vein Island Isolation and Left Appendage Base Closure
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fujian Medical University
Congenital Heart Defects
Outcomes in Patients and Their Closest Relatives Treated for Congenital Heart Disease With Catheter Based or Surgical Techniques
This study compares clinical, self- reported and cost outcomes in children and adolescents treated with pulmonary valve implantation, percutaneous versus open surgical technique.
- Trial name
- MEQC (NCT01421030)
- Testing
- Percutaneous pulmonary valve implantation or open heart surgery
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Tricuspid Regurgitation
Minimally Invasive Tricuspid Surgery vs Medical Treatment for Severe TR
Late tricuspid regurgitation (TR) is a common complication after left-sided valve surgery (LSVS), which usually progresses slowly and results in right heart failure at terminal stage.
- Trial name
- NCT04339192
- Testing
- Minimally Invasive Tricuspid Surgery
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Paroxysmal Atrial Fibrillation, Coronary Artery Disease
Surgical Pulmonary Vein Isolation Efficiency Study
A substantial proportion of patients undergoing elective coronary artery bypass grafting have a history of paroxysmal atrial fibrillation. Paroxysmal atrial fibrillation has adverse short-and long term postoperative effects.
- Trial name
- FIN-PVI (NCT01791218)
- Testing
- CABG, AVR or CABG+AVR and PVI, CABG, AVR or CABG+AVR
- Where
- Finland
- Volunteers
- 2 people
- Sponsor
- Kuopio University Hospital
Aortic Stenosis, Multi Vessel Coronary Artery Disease
The TransCatheter Valve and Vessels Trial
The trial objective is to investigate whether Fractional Flow Reserve (FFR)-Guided Percutaneous Coronary Intervention (PCI) and TransCatheter Aortic Valve Implantation (TAVI) strategy for treatment of multivessel disease and…
- Conditions
- Aortic Stenosis, Multi Vessel Coronary Artery Disease, TAVI, CABG
- Trial name
- TCW (NCT03424941)
- Testing
- FFR-guided PCI and TAVI, CABG and SAVR
- Where
- 20 sites in Austria, Denmark and 8 more
- Volunteers
- 172 people
- Sponsor
- Maatschap Cardiologie Zwolle
Aortic Valve Stenosis
Clinical Evaluation of Percutaneous Implantation of the Medtronic CoreValve Aortic Valve Prosthesis (18Fr-Study)
The investigation concerns a prospective, multicenter, single arm safety and performance study evaluating the Medtronic CoreValve system.
- Trial name
- NCT01051518
- Testing
- Medtronic CoreValve System
- Where
- 9 sites in Canada, Germany and 2 more
- Volunteers
- 126 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Mitral Valve Regurgitation
OPtimisation of Surgical Repair for Treating Insufficiency of the MItral Valve - Safety Evaluation
The optimal surgical approach in functional mitral regurgitation (MI) was questioned in favour for prosthetic replacement due to the reduced risk of recurrent MI . However, adjustable mitral rings may provide an alternative .
- Trial name
- NCT03842397
- Testing
- Kephalios Device 1
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Kephalios
Coronary Artery Bypass Grafting, Surgical Treatment for Heart Valve Diseases
China Cardiovascular Surgery Registry
China Cardiovascular Surgery Registry (CCSR) Study is a national database for coronary artery bypass grafting (CABG) and valve surgery performed in 87 hospitals with cardiovascular surgery volume > 100 per year.
- Trial name
- CCSR (NCT02400125)
- Where
- China
- Volunteers
- 90,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Alternative Surgical Treatment for Aortic Valve Disease
TriRec - Trileaflet Reconstruction of the Aortic Valve With Autologous Pericardium
Reconstruction of the aortic valve using the tri-leaflet repair technique is non-inferior with regard to effective orifice area (EOA) to surgical aortic valve replacement (SAVR) with a biological prosthesis (St.
- Trial name
- TriRec (NCT03600662)
- Testing
- TriRec, Aortic valve replacement
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Right Ventricular Outflow Tract Absent, Congenital Heart Disease
New Designed ePTFE Valved Conduits for Surgical Reconstruction of Right-ventricular Outflow Tract
Valved conduits used for the reconstruction of right-ventricular outflow tract are applied in the surgical repair of complex congenital heart disease(CHD) such as pulmonary atresia(PA), truncus arteriosus, severe tetralogy of…
- Conditions
- Right Ventricular Outflow Tract Absent, Congenital Heart Disease, Pulmonary Valve Disorders
- Trial name
- NCT04152967
- Testing
- new-designed PTFE valved conduits, Bovine jugular vein valved conduits
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Mitral Valvulopathy, Atrial Fibrillation
Comparison of Treatment of Atrial Fibrillation (AF) Between Surgical Ultrasonic Technology or Drug Therapy for Patients With AF Requiring Mitral Valve Surgery
In pre-operative cardiac surgery, 30 to 40% of patients with mitral valvulopathy have had episodes of paroxysmal atrial fibrillation (PAF) or are in permanent or chronic atrial fibrillation (CAF).
- Trial name
- EPICAF (NCT01649544)
- Testing
- EPICOR, Amiodarone
- Where
- 5 sites in France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne