Clinical trials: Surgical Wound, Healed
CerebroSpinal Fluid (CSF) Leak
NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery
Postoperative cerebrospinal fluid (CSF) leak is a significant complication of endoscopic endonasal approaches (EEA) to the skull base.
- Trial name
- NoSeal (NCT07216157)
- Testing
- Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant
- Where
- Poland
- Volunteers
- 225 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Wound Healing, Mohs Micrographic Surgery
Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds
Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in wound healing over the past several years.
- Trial name
- NCT06941467
- Testing
- Timolol Maleate Solution, Standard of Care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
HIV
Observational Study of Male Circumcision Using PrePex Device
The study will measure the incidence of moderate and severe adverse events (AEs) associated with PrePex procedures, including both procedural and post-procedure events, and all device-related incidents such as dislodgment.
- Trial name
- NCT01711411
- Testing
- PrePex device for male circumcision
- Where
- Kenya
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- FHI 360
Evaluate Surgical, Medical and Pharmacological Factors Influence on Wound Healing Following Primary Arthroplasty Surgery
Identification of Risk Factors of Prolonged Wound Healing Following Primary Arthroplasty
Prolonged wound drainage following total joint replacement surgery has been shown to be a predictor of postoperative infection. Several factors have been associated with delayed wound healing and increased risk of infection.
- Trial name
- NCT01477047
- Where
- Denmark
- Volunteers
- 1,500 people
- Sponsor
- Hvidovre University Hospital
Healing Surgical Wounds, Pain Measurement
Effects of Laser Stimulation on Wound Healing of Human Palatal Tissue
The purpose of this study is to assess the effects of photobiomodulation (PBM) with an Er:YAG laser on the palatal donor site following subepithelial connective tissue graft (SECTG) surgery.
- Trial name
- NCT03741062
- Testing
- J. Morita AdvErl Evo Er:YAG laser, Control
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers (VLUs)
Study of Miro3D Wound Matrix for Healing Wounds and Ulcers in Outpatient Care
This clinical study is being conducted to evaluate how well the Miro3D Wound Matrix helps heal difficult wounds and ulcerations in an outpatient care setting.
- Conditions
- Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers (VLUs), Pressure Ulcers, Surgical Wound Dehiscence (SWD)
- Trial name
- NCT06939673
- Testing
- Acellular Porcine-Derived Wound Matrix
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Reprise Biomedical, Inc.
Hemorrhoids
Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery
The subjects of this study were patients who took mixed haemorrhoidectomy during the period of December 2024 - December 2025 . The haemorrhoidectomy patients were randomly divided into routine group, red light group and red and…
- Trial name
- NCT07121686
- Testing
- Red light exposure, Red-blue light exposure
- Where
- China
- Volunteers
- 315 people
- Sponsor
- The Affiliated Hospital of Putian University
Healing Surgical Wounds
Platelet Rich Fibrin in Soft Tissue Healing After Implant Uncovering
This study represents a prospective, controlled and randomized clinical trial assessing the effects of L-PRF on the healing time of the donor area and on the patient's postoperative morbidity in the 4 weeks following the Apically…
- Trial name
- NCT05375357
- Testing
- Application of L-PRF on the donor area, Secondary intention healing of the donor area
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Surgical Wound, Healed
Activated Carbon Interphase Effect on Surgical Incisions vs.Two Common Wound Dressings
This randomized, prospective study evaluates incision closure, post-surgical wound complications, dressing changes, incision/scar appearance, pain associated with dressing changes, and patient satisfaction rates of an activated…
- Trial name
- NCT04038671
- Testing
- Activated Carbon Cloth Dressing, Knitted Cellulose Acetate Mesh, Antimicrobial Alginate Dressing with Silver
- Where
- 2 sites in United States
- Sponsor
- Brock Liden, DPM
Wound Healing, Surgical Wound
Evaluating rhPDGF-BB-Enhanced Wound Matrix for Head and Neck Reconstruction
Skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma lesions that develop on the head and neck are treated by Mohs surgery or wide local excision to remove all tumor cells and preserve the…
- Trial name
- NCT06634030
- Testing
- RhPDGF-BB, Saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt University Medical Center
Quality of Life, Biopsy Wound
Oral Biopsies: Evaluation of the Post-surgical Discomfort
Aim of this study is to evaluate the post-operative course in patients undergoing diagnostic or therapeutic oral mucosal biopsies.
- Conditions
- Quality of Life, Biopsy Wound, Surgical Wound, Healing Surgical Wounds
- Trial name
- NCT04514263
- Testing
- OHIP-14 Administration, VNS Administration
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Catholic University of the Sacred Heart
Postoperative Abdominal Wounds, Wound-healing Impairments
Evaluate the Efficacy of the Treatment of Iatrogenic Subcutaneous Abdominal Wounds (ISAW) After Surgery by Application of Negative Pressure Wound Therapy (NPWT) in Comparison to Standard Conventional Wound Therapy (SCWT) of the Clinical Routine
The purpose of this study is to determine whether Negative Pressure Wound Therapy (NPWT) or Standard Conventional Wound Therapy (SCWT) are effective in the treatment of Iatrogenic Subcutaneous Abdominal Wound healing-impairments…
- Trial name
- ISAW (NCT01611207)
- Testing
- Negative Pressure Wound Therapy, Standard Wound Therapy
- Where
- 34 sites in Germany
- Volunteers
- 12 people
- Sponsor
- University of Witten/Herdecke
Impacted Third Molar Tooth, Healing Surgical Wounds
Evaluation of Hydrogen Peroxide and Hyaluronic Acid (BMG0703) in the Healing of Post-extraction Sites
A clinical study to evaluate the efficacy and safety of a mouthwash containing Hydrogen Peroxide, Sodium Hyaluronate and Glycine in the healing of post-extraction sites of wisdom teeth by film forming action.
- Trial name
- NCT04438434
- Testing
- Filming Formulation of Hydrogen Peroxide and Hyaluronic Acid, Chlorhexidine mouthwash
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- University of Milan
Wound Healing After MMS Surgery, BCC - Basal Cell Carcinoma
Effectiveness and Safety of X A-DERM™ Microsurfaced Acellular Dermal Matrix for Wound Healing After MOHS Surgery
The goal of this single-arm clinical trial is to learn about the effectiveness and safety of the X A-DERM™ mADM in promoting wound healing and improving scar formation after MMS surgery for removing BCC, SCC, or MIS lesions on…
- Conditions
- Wound Healing After MMS Surgery, BCC - Basal Cell Carcinoma, SCC - Squamous Cell Carcinoma, Melanoma In Situ
- Trial name
- NCT06919809
- Testing
- A microsurfaced ADM (acellular dermal matrix)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- McGuire Institute
Chronic Rhinosinusitis With Nasal Polyps
Effect of Oral Vitamin D3 on Chronic Rhinosinusitis Treatment in Adults With Lower Vitamin D Levels
The purpose of the study is to test the clinical efficacy of oral Vitamin D3 on Wound Healing in patients with Chronic Rhinosinusitis With Nasal Polyposis and Lower Vitamin D Levels After Endonasal Endoscopic Sinus Surgery
- Trial name
- NCT02668861
- Testing
- Vitamin D, Budesonide Nasal Spray
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Shanxi Medical University
Wound Healing
Cell Suspension With Biologic Dressing for Burn Wounds
This study is a prospective, multicenter, real-world observational study. It aims to evaluate the effectiveness and safety of a combined therapy-autologous epidermal cell suspension followed by biological dressing (porcine…
- Trial name
- NCT07555418
- Testing
- Autologous Epidermal Cell Suspension
- Volunteers
- 386 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Wound Infection Rate After Surgery, Impact of Wound Infection on Pain and Wound Healing
Impact of Preoperative Local Water-Filtered Infrared-A (wIRA) Irradiation on Postoperative Wound Healing
The purpose of this study is to dermine whether local-water filtered infrared-A (wIRA) irradiation can reduce postoperative wound infection.
- Trial name
- Hydrosun (NCT01654679)
- Testing
- wIRA irradiation, visible light only
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- German Research Foundation
Postoperative Complications
Effect of Probiotics on Pain and Oral Wound Healing After Third Molar Surgery
The aim of this research is to study the effect of probiotic supplements (Lactobacillus reuteri) on post-surgical complications and oral wound healing after extraction of impacted third molars.
- Trial name
- PROVIS (NCT02572531)
- Testing
- L. reuteri DSM 17938/ATCC PTA
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Wound
Doubleblinded RCT of the Omnilux on Lower Extremity Surgical Wounds Left to Heal by Second Intention
The goal of the study is to evaluate the effectiveness of the light-emitting diode (LED) in promoting healing of the wound on lower leg as a result of surgery.
- Trial name
- NCT02383056
- Testing
- Omnilux
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Miami
Surgical Wound Healing, Scar Tissue
Reducing Wound Complications in Breast Surgery Using hACM
The purpose of this study is to evaluate whether intraoperative application of human amnion chorion membrane (hACM) improves wound healing and scar outcomes in breast surgery.
- Trial name
- NCT07881939
- Testing
- Dehydrated Human Amnion Chorion Membrane
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey