Clinical trials: Surgical Wound Healing
Mitral Valve Insufficiency, Coronary Artery Disease
REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial
Ischemic mitral regurgitation (MR) and coronary artery disease is common and associated with significant morbidity and mortality.
- Trial name
- REVIVE (NCT04822675)
- Testing
- Percutaneous mitral valve repair, Surgical mitral valve repair/replacement
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Postpartum Bleeding, Vaginal Lacerations
Hemcon© Bandage for Postpartum Bleeding Due to the Multiple Vaginal Lacerations
The objective of the study is to assess the safety and efficacy of the HemCon GuardaCareXR compared to standard bandaging in subjects with post partum hemorrhage as a result of cervical and vaginal lacerations.
- Conditions
- Postpartum Bleeding, Vaginal Lacerations, Cervical Lacerations
- Trial name
- NCT01373801
- Testing
- The HemCon GuardaCare, Control
- Where
- Israel
- Volunteers
- 85 people
- Sponsor
- Soroka University Medical Center
Cartilage Injury of Knee
A Multicenter Trial of Sprifermin (AS902330 [Recombinant Human Fibroblast Growth Factor-18]) or Placebo After Microfracture Surgery for Cartilage Injury of the Knee
This is a Phase 2, double-blind, multicenter, randomized, placebo-controlled trial to evaluate the efficacy and safety of Sprifermin (AS902330) (recombinant human fibroblast growth factor-18 [rhFGF-18]) as an adjunct treatment to…
- Trial name
- NCT01689337
- Testing
- Sprifermin (AS902330)
- Volunteers
- 1 people
- Sponsor
- EMD Serono
Laceration
A Randomized Post-market Study to Evaluate Zip Device Compared to Sutures for Laceration Repair in Pediatrics and Adults
The Zip-009 clinical investigation will enroll 26 paediatric and adult subjects requiring laceration repair and fulfilling the eligibility criteria for the clinical investigation.
- Trial name
- NCT03199456
- Testing
- Zip surgical skin closure device, Standard of Care sutures
- Where
- 2 sites in Sweden
- Volunteers
- 26 people
- Sponsor
- ZipLine Medical Inc.
Anterior Cruciate Ligament Repair
Minimizing Tourniquet Pressures in Paediatric Orthopaedic Knee Surgery
Tourniquet cuffs are routinely used to stop blood flow in patients' arms or legs during surgery. This allows surgeons to better visualize anatomical structures during the procedure.
- Trial name
- NCT00439153
- Testing
- Tourniquet instrument capable of measuring LOP in combination with tourniquet cuffs
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- University of British Columbia
Thoracic Aneurysm, Aneurysm Stent
The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.
Alzheimer's disease represents a growing public health problem in developed countries. Although the pathogenesis is not clearly defined, accumulation of extracellular amyloid, neurofibrillary tangles and neuronal loss are the…
- Conditions
- Thoracic Aneurysm, Aneurysm Stent, Cardiopulmonary Bypass, Abdominal Aneurysm
- Trial name
- NCT01772537
- Testing
- Propofol, isoflurane
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Wound Healing
Clinical Efficacy of a Chlorhexidine-based Mouth-rinse Containing Citrus Aurantium Amara
The primary objective of the study is the evaluation of efficacy of a mouthwash cointaining Chlorexidine (CHX) 0.09% + HA + Citrox (test group) on the quality of wound healing and the presence plaque formation and gingival…
- Trial name
- CUR_01 (NCT06738342)
- Testing
- CHX 0.09% + Citrox + HA, CHX 0.12%
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Hidradenitis Suppurativa, Surgical Wound
Wet-to-dry vs Petrolatum & Non-stick Dressings After Hidradenitis Suppurativa Surgery
Hidradenitis suppurativa (HS) is a chronic, severe, inflammatory skin disease associated with pain, drainage, odor, and disability characterized by recurring abscesses, nodules, and tunneling sinuses in intertriginous locations…
- Trial name
- NCT05194969
- Testing
- Wet-to-Dry Dressings, Petrolatum with Non-Stick Gauze
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of North Carolina, Chapel Hill
Incisional Hernia, Hernia
Comparison of Mesh Fixation Techniques in Elective Laparoscopic Repair of Incisional Hernia - ReliaTack™ v ProTack™
This study is designed to examine the effects on post operative pain after the use of a fixation device to secure a mesh in the abdomen to repair a hernia of the abdominal wall.
- Conditions
- Incisional Hernia, Hernia, Abdominal Hernia
- Trial name
- TACKoMesh (NCT03434301)
- Testing
- ReliaTack™, Protack™
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Manchester University NHS Foundation Trust
Gingival Hyperplasia, Gingival Hypertrophy
Testing the Efficacy of Photobiomodulation Therapy and Hyaluronic Acid Gel on Post-surgical Healing After Gingivectomy
This study consists of random patient selection and allocating them in 3 different groups. After being fit to be included according to the protocol's criteria and signing an informed consent, patients will be distributed after…
- Conditions
- Gingival Hyperplasia, Gingival Hypertrophy, Gingival Overgrowth, Gingival Enlargement
- Trial name
- NCT07169357
- Testing
- Gengigel, LASER
- Where
- Lebanon
- Volunteers
- 38 people
- Sponsor
- Beirut Arab University
Rotator Cuff Repair
Unexpected Positive Cultures in Rotator Cuff Revision Surgery
In the context of rotator cuff re-intervention, the impact of Unexpected Positive Cultures (UPC) is not documented, and their management has not been studied, particularly regarding indications for antibiotic therapy, which is…
- Trial name
- POCICO (NCT06257979)
- Testing
- This study is with minimal risk and minimal constraints due to the addition of questionnaires
- Where
- 8 sites in France
- Volunteers
- 132 people
- Sponsor
- Elsan
Severe Mitral Valve Regurgitation (Disorder)
Transcatheter Versus Standard Surgical Mitral Valve Operation for Secondary Mitral Regurgitation
The mechanical intervention is treating secondary mitral regurgitation (SMR) which may be performed using the standard open surgical approach or transcatheter edge to edge repair (TEER).
- Trial name
- TEERMISO (NCT05090540)
- Testing
- Trancatheter Edge to Edge Repair, Mitral Valve Replacement, Restrictive Mitral Annuloplastie
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Centre Cardiologique du Nord
Mitral Regurgitation
TEER for Severe DMR of Low to Intermediate Surgery Risk
To investigate the efficacy and safety of transcatheter mitral valve edge-to-edge repair (TEER) for severe degenerative mitral regurgitation (DMR) patients of low to intermediate surgery risk.
- Trial name
- NCT06162780
- Testing
- ultrasonic cardiography (UCG), TEER
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Nerve Block, Cardiac Surgery
Timing Effect of Ultrasound-Guided PVB After Robotic Cardiac Surgery
This study is to evaluate whether the administration of ultrasound-guided paravertebral block (PVB) after surgery would produce better postoperative pain control and fast postoperative recovery after Robotic cardiac surgery.
- Trial name
- NCT04298580
- Testing
- PVB block
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Vaginal Vault Prolapse
Laparoscopic Sacropexy With Robot-Assisted Surgical System
The aim of the study is to evaluate safety and outcome of robot-assisted laparoscopic sacropexy regarding perioperative data, objective anatomical results and postoperative quality of life.
- Trial name
- RobPex (NCT00886223)
- Testing
- laparoscopic robot-assisted sacropexy
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Aarau
Anterior Cruciate Ligament Tear, Medial Collateral Ligament
A Study to Evaluate the Incrediwear Products Immediately After ACL Repair
To assess the benefits of using the Incrediwear knee products after ACL or ACL+MCL arthroscopic surgery, on the postoperative pain, range of motion and effusion.
- Trial name
- NCT06668376
- Testing
- Leg Sleeve
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Texas Bone and Joint
Shoulder Pain, Postoperative Pain
Suprascapular Nerve Block Efficacy for Shoulder Surgery
This study evaluates the analgesia induced by suprascapular nerve block in comparison to interscalene nerve block in arthroscopic rotator cuff repairs.
- Conditions
- Shoulder Pain, Postoperative Pain, Rotator Cuff Tears, Anesthesia
- Trial name
- NCT04364542
- Testing
- Suprascapular nerve block, Interscalene Nerve Block, Arthroscopic rotator cuff repair
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Ivan Simionato
Post-Surgical Complication, Breast Cancer Surgery
The Efficacy of Using Pentoxifylline in Patients Undergoing Breast Cancer Surgery
The goal of this clinical trial is to assess the efficacy of pentoxifylline in reducing postsurgical complications for breast cancer patients undergoing breast cancer surgery.
- Trial name
- NCT06087237
- Testing
- Pentoxifylline, paracetamol +ketorolac
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Mansoura University
Surgery, Pain, Postoperative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll.
- Trial name
- CARES (NCT05722002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 8 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Recurrant Inguinal Hernia
Outcomes of Laparoscopic Keyhole Surgery (TAPP) for Recurrent Inguinal Hernia
The goal of this clinical trial is to learn if a laparoscopic surgery called Transabdominal Preperitoneal (TAPP) repair is safe and works well for adults with a recurrent inguinal hernia (a groin hernia that has returned after a…
- Trial name
- NCT07608653
- Testing
- Laparoscopic Transabdominal Preperitoneal (TAPP) Repair
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Sohag University
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