Clinical trials: Suzetrigine
Diabetic Peripheral Neuropathic Pain
Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine in participants with pain associated with diabetic peripheral neuropathy (DPN).
- Trial name
- NCT07231419
- Testing
- Suzetrigine
- Where
- 75 sites in United States
- Volunteers
- 734 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain Detection, Pain Threshold
Pharmacodynamic Study of 100mg Suzegtrigine vs Placebo in Healthy Male Adults
This is a randomized, double-blind, placebo-controlled within-participant crossover study in healthy male participants 18-55 years of age to assess pain tolerance during a cold pressor test.
- Trial name
- NCT06972212
- Testing
- suzetrigine 100mg
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Latigo Biotherapeutics
Diabetic Peripheral Neuropathic Pain
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
- Trial name
- NCT06628908
- Testing
- Suzetrigine, Pregabalin
- Where
- 76 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation and Strength of Suzetrigine
The purpose of this study is to evaluate the pharmacokinetics (PK) of suzetrigine (SUZ; VX-548) and its metabolite along with its safety and tolerability, in healthy participants.
- Trial name
- NCT06336096
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Pain
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
- Trial name
- NCT06887959
- Testing
- Suzetrigine
- Where
- 17 sites in United States
- Volunteers
- 47 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
Evaluation of the Effect of Suzetrigine (SUZ) on the Pharmacokinetics of Oral Contraceptives in Healthy Female Participants
The purpose of this study is to evaluate the effect of SUZ on the pharmacokinetics of oral contraceptives.
- Trial name
- NCT06820307
- Testing
- Suzetrigine, DRSP/EE, NGM/EE
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
Effects of Efavirenz on the Pharmacokinetics of Suzetrigine in Healthy Participants
The purpose of the study is to evaluate the pharmacokinetics (PK) of Suzetrigine (SUZ) and its metabolite in the absence and presence of efavirenz, a moderate CYP3A inducer.
- Trial name
- NCT07570069
- Testing
- Suzetrigine, Efavirenz
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Pain
A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries
The purpose of this study to evaluate the effectiveness, safety, and tolerability of SUZ as part of multimodal therapy (MMT) in treating acute postoperative pain.
- Trial name
- NCT06887972
- Testing
- Suzetrigine
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
Evaluation of the Excretion of Suzetrigine Into Breast Milk in Healthy Lactating Female Participants
The purpose of the study is to evaluate the pharmacokinetics (PK) of suzetrigine (SUZ) and its active metabolite in breast milk of lactating female participants.
- Trial name
- NCT07378865
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Diabetic Peripheral Neuropathic Pain
Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN)
The purpose of this study is to evaluate the long-term safety and tolerability of SUZ and long-term effectiveness of SUZ in treating pain associated with DPN.
- Trial name
- NCT06696443
- Testing
- Suzetrigine
- Where
- 65 sites in United States
- Volunteers
- 455 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Pain
Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty
The purpose of this study was to evaluate the efficacy and safety of Suzetrigine (SUZ) in treating acute pain after an abdominoplasty.
- Trial name
- NCT05558410
- Testing
- Suzetrigine (SUZ), HB/APAP
- Where
- 12 sites in United States
- Volunteers
- 1,118 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
A Study of Suzetrigine (SUZ) Spray-dried Dispersion (SSD) in Healthy Adult Panelists
The purpose of this study is to evaluate the sensory attributes (basic tastes, aroma, texture, mouthfeel) of SUZ SDD and assess the impact of the dose on the sensory attributes.
- Trial name
- NCT06834009
- Testing
- SUZ
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated