Clinical trials: Suzetrigine
Pain
A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation and Strength of Suzetrigine
The purpose of this study is to evaluate the pharmacokinetics (PK) of suzetrigine (SUZ; VX-548) and its metabolite along with its safety and tolerability, in healthy participants.
- Trial name
- NCT06336096
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Nail Diseases
Post-op Analgesia of Nail Unit Procedures
The purpose of this study is to directly compare the efficacy of suzetrigine vs. oxycodone+acetaminophen vs. alternating acetaminophen/ibuprofen in controlling post-operative pain after the following nail unit procedures.
- Trial name
- NCT07820969
- Testing
- Suzetrigine, Oxycodone/Acetaminophen, Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Miami
Postoperative Pain, Acute Pain
Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery
This randomized clinical trial will compare suzetrigine with standard analgesia for postoperative pain management after skin cancer surgery.
- Conditions
- Postoperative Pain, Acute Pain, Skin Cancer, Cutaneous Malignancy
- Trial name
- NCT07843134
- Testing
- Suzetrigine, Acetaminophen Plus Ibuprofen
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- University of Minnesota
Spine Fusion, Postoperative Pain
Suzetrigine (Journavx) for Pain Management After Spine Surgery
This prospective, single-center interventional study will evaluate the effect of suzetrigine (Journavx), a selective NaV1.8 inhibitor, on postoperative opioid requirements in patients undergoing spine surgery.
- Trial name
- NCT07829718
- Testing
- Suzetrigine (Journavx)
- Volunteers
- 110 people
- Sponsor
- Ohio State University
Postoperative Pain Management
Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports
The goal of this clinical trial is to learn if a Suzetrigine-based multimodal pain regimen can reduce the volume of opioid consumption while maintaining non-inferior pain control compared to an opioid-based multimodal pain…
- Trial name
- NCT07355166
- Testing
- Suzetrigine, Multimodal Pain Regimen
- Volunteers
- 140 people
- Sponsor
- University of California, Los Angeles
Pain, Acute Postoperative, Breast Disease
Suzetrigine for Non-Mastectomy Breast Surgery
This is a single-center clinical study to investigate the efficacy of a Food and Drug Administration-approved analgesic, suzetrigine, to treat pain following non-mastectomy breast surgery in concert with a single-injection…
- Trial name
- NCT07463430
- Testing
- suzetrigine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Pain
Effects of Efavirenz on the Pharmacokinetics of Suzetrigine in Healthy Participants
The purpose of the study is to evaluate the pharmacokinetics (PK) of Suzetrigine (SUZ) and its metabolite in the absence and presence of efavirenz, a moderate CYP3A inducer.
- Trial name
- NCT07570069
- Testing
- Suzetrigine, Efavirenz
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Diabetic Peripheral Neuropathic Pain
Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN)
The purpose of this study is to evaluate the long-term safety and tolerability of SUZ and long-term effectiveness of SUZ in treating pain associated with DPN.
- Trial name
- NCT06696443
- Testing
- Suzetrigine
- Where
- 65 sites in United States
- Volunteers
- 455 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Pain
Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty
The purpose of this study was to evaluate the efficacy and safety of Suzetrigine (SUZ) in treating acute pain after an abdominoplasty.
- Trial name
- NCT05558410
- Testing
- Suzetrigine (SUZ), HB/APAP
- Where
- 12 sites in United States
- Volunteers
- 1,118 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Rib Fractures
Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures
Rib fractures cause a significant amount of pain and are associated with an increased risk of lung infections, long hospitalization, and increased cost.
- Trial name
- NCT07145346
- Testing
- Suzetrigine (SUZ)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine
Postoperative Pain Following Knee Arthroplasty
Evaluating Suzetrigine for Pain Control Following TKA
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine works to treat pain after total knee replacement surgery in adults. It will also learn about the safety of suzetrigine.
- Trial name
- NCT07357376
- Testing
- Suzetrigine
- Volunteers
- 210 people
- Sponsor
- AdventHealth
Pain Control
RCT: Suzetrigine vs Norco for Post-op Pain
Journavx (suzetrigine) is a novel non-opioid analgesic that is FDA approved for acute pain management and may offer a promising alternative for managing postoperative pain.
- Trial name
- NCT07195669
- Testing
- Suzetrigine (SUZ), Norco
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Jacob Lensing
Cesarean Delivery, Cesarean Section
Suzetrigine for Opioid-Free Recovery After Cesarean Delivery
The goal of this clinical trial is to determine whether suzetrigine increases the proportion of patients who remain completely opioid-free from completion of surgery through 72 hours after cesarean delivery.
- Conditions
- Cesarean Delivery, Cesarean Section, Pain, Postoperative, Opioid Consumption, Postoperative
- Trial name
- SPARE (NCT07534709)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Texas at Austin
Pain Detection, Pain Threshold
Pharmacodynamic Study of 100mg Suzegtrigine vs Placebo in Healthy Male Adults
This is a randomized, double-blind, placebo-controlled within-participant crossover study in healthy male participants 18-55 years of age to assess pain tolerance during a cold pressor test.
- Trial name
- NCT06972212
- Testing
- suzetrigine 100mg
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Latigo Biotherapeutics
Cutaneous Tumors, Mohs Micrographic Surgery
Suzetrigine vs Norco-postoperative Mohs Pain
To compare suzetrigine versus hydrocodone/acetaminophen for postoperative pain control following dermatologic surgery.
- Trial name
- NCT07575230
- Testing
- Norco 5Mg-325Mg Tablet, Suzetrigine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Baylor Research Institute
Acute Pain
A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries
The purpose of this study to evaluate the effectiveness, safety, and tolerability of SUZ as part of multimodal therapy (MMT) in treating acute postoperative pain.
- Trial name
- NCT06887972
- Testing
- Suzetrigine
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Pain
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
- Trial name
- NCT06887959
- Testing
- Suzetrigine
- Where
- 17 sites in United States
- Volunteers
- 47 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Postoperative Pain
Suzetrigine Added to Multimodal Analgesia for Women Undergoing Minimally Invasive Hysterectomy
This study will assess the analgesic efficacy of suzetrigine as part of a multimodal analgesic regimen in women undergoing laparoscopic or robotic hysterectomy.
- Trial name
- NCT07836010
- Testing
- Suzetrigine
- Volunteers
- 123 people
- Sponsor
- Duke University
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\)
Suzetrigine in Total Hip Arthroplasty
Total hip and knee joint replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\), Total Hip Replacement, Total Hip Replacement Surgery
- Trial name
- NCT07226700
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York