Clinical trials: Sympathectomy
Facial Blushing
Thoracoscopic Sympathectomy for Blushing
To determine outcome and side effects following thoracoscopic sympathectomy in patients treated for disabling isolated facial blushing and investigate if there are any significant differences between two different routine…
- Trial name
- NCT00225069
- Testing
- Level of sympathectomy
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Pediatric Thoracoscopy
Retrolaminar Block for Pediatric Thoracoscopic Sympathectomy
Thoracoscopic sympathectomy is a rapid and simple technique associated with rare complications, but it is associated with severe postoperative pain that makes breathing and coughing difficult resulting in increased occurrence of…
- Trial name
- NCT04688918
- Testing
- Retrolaminar block, paravertebral group
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Hypertension, Uncontrolled Hypertension
A Study of Non-Vascular Renal Denervation Using the Verve Medical Phoenix ™ System
The aim of the study is to assess the safety and effectiveness of a novel device for renal denervation to lower blood pressure in people with uncontrolled hypertension.
- Trial name
- TUSK (NCT05440513)
- Testing
- Renal Pelvic Denervation (bilateral)
- Where
- 2 sites in Georgia
- Volunteers
- 20 people
- Sponsor
- Verve Medical, Inc
Hypertension, Resistant to Conventional Therapy
Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography
The purpose of this study is to demonstrate that Renal Sympathetic Denervation (RDN) improves the control of blood pressure (BP) in patients with treatment-resistant hypertension, as compared to intensive medical therapy (IMT)…
- Trial name
- OsloRDN (NCT01673516)
- Testing
- The SymplicityTM Renal Denervation System, The HOTMAN® System
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Heart Failure
Study of Renal Denervation in Patients With Heart Failure
Congestive heart failure is a common disorder in which the heart cannot pump enough blood to meet the needs of the rest of the body.
- Trial name
- PRESERVE (NCT01954160)
- Testing
- Symplicity Renal Denervation
- Where
- 12 sites in United States
- Volunteers
- 5 people
- Sponsor
- Adrian Hernandez
Intraoperative Complications
Study of Different Concentrations of Epidural Bupivacaine for the Effects on Vasodilatation and Sensory Block
This study aims to compare human subjects receiving epidural bupivacaine local anesthetic at different doses and concentrations and to assess the effect on vasodilatation (sympathectomy), sensory and motor block.
- Trial name
- NCT00197353
- Testing
- Epidural bupivacaine (dose/concentration/volume ranging)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Atrial Fibrillation
Renal Nerve Denervation After Pulmonary Vein Isolation for Persistent Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia and it is associated with significant morbidity and mortality. Electrical isolation of the pulmonary vein (PVI) by radiofrequency energy or cryoablation has been shown to be…
- Trial name
- NCT03246568
- Testing
- Renal Nerve Denervation, Pulmonary vein isolation
- Where
- Hong Kong
- Volunteers
- 3 people
- Sponsor
- Chinese University of Hong Kong
Diabetes
Renal Denervation in Diabetes.
Renal denervation (the use of radio waves to oblate the renal artery) has been shown to be an effective treatment for high blood pressure.
- Trial name
- NCT02081989
- Testing
- Renal denervation
- Where
- Australia
- Sponsor
- Monash University
Diabetes, Endocrine, Nutritional and Metabolic Diseases (E00-E89)
COMPLEMENT Study- A First in Human Study of Metabolic Neuromodulation Therapy
The purpose of this research study is to collect information about a new treatment for Type 2 Diabetes Mellitus (T2DM), using a medical device called the Metabolic Neuromodulation System which is intended to help regulate blood…
- Trial name
- NCT02278068
- Testing
- Metabolic Neuromodulation System (MNS)
- Where
- 6 sites in New Zealand
- Volunteers
- 46 people
- Sponsor
- Metavention
Hypertension
Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy
Non-randomized study of 5 subjects that have been selected for prophylactic open surgery due to abdominal aortic aneurysm. During surgery the renal arteries are identified and subjected to about 60 seconds each of freezing by…
- Trial name
- PRASDEN (NCT02345603)
- Testing
- Cryo-therapy
- Where
- Sweden
- Volunteers
- 9 people
- Sponsor
- University Hospital, Linkoeping
Anesthesia, Conduction, Nerve Block
Regional Changes in Upper Limb Perfusion Following Brachial Plexus Block: A Pilot Study
Ultrasound-guided regional anesthesia is increasingly being used in the modern surgical environment to provide specific intraoperative anesthesia and postoperative analgesia.
- Conditions
- Anesthesia, Conduction, Nerve Block, Sympathectomy, Regional Blood Flow
- Trial name
- RAFFAB (NCT02589054)
- Testing
- Monitoring
- Volunteers
- 18 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hyperhidrosis Due to Autonomic Dysregulation (Disorder)
Extended Versus Limited Thoracoscopic Sympathectomy: Its Impact on Palmar and Plantar Hyperhidrosis
Conclusions: In the context of palmar and plantar hyperhidrosis, extended thoracoscopic sympathectomy seemed to be preferred over limited thoracoscopic sympathectomy due to better overall outcomes and minimal time for hospital…
- Trial name
- NCT06219655
- Testing
- thoracoscopic sympathectomy
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Persistent Atrial Fibrillation
Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
This is a pilot study to assess the usefulness of ECG mapping, and enhanced MRI and PET scan imaging in identifying atrial fibrosis and arrhythmia circuits involved in persistent atrial fibrillation and in guiding an innovative…
- Trial name
- COAST-AF (NCT02184013)
- Testing
- Catheter ablation
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Metabolic Syndrome
Renal Sympathetic Denervation in Metabolic Syndrome (Metabolic Syndrome Study)
The purpose of this clinical investigation is to determine the effects of renal sympathetic denervation on insulin resistance and muscle sympathetic nerve activity in patients with metabolic syndrome.
- Trial name
- NCT01911078
- Testing
- Renal Denervation, EnligHTN™ Renal Denervation System.
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Analgesia
Evaluation of T2, T3 Sympathectomy for Postmastectomy Pain Syndrome by Pulse Oximeter
The aim of the study is to compare the efficacy of T2, T3 sympathetic block using thermal radiofrequency versus chemical neurolysis in postmastectomy pain syndrome using perfusion index derived from pulse oximetry.
- Trial name
- NCT04953507
- Testing
- Thermal Radiofrequency, Chemical Neurolysis
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute, Egypt
Ventricular Arrhythmias, Electrical Storm
Cardiac Sympathetic Denervation in Patients With Refractory Arrhythmic Storm: a Single-center Case Series
The objective of our study was to evaluate the effectiveness of stellate ganglion block (SGB) and of the bilateral cardiac sympathetic denervation (BCSD) in patients with electrical storm refractory to conventional treatment..
- Conditions
- Ventricular Arrhythmias, Electrical Storm, Stellate Ganglion Block
- Trial name
- NCT07375264
- Testing
- Cardiac sympathetic denervation.
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Jose Manuel López González
Systolic Heart Failure, Beta-blockers Intolerance
Surgical Sympathetic Blockade in Heart Failure
The investigators sought to evaluate the feasibility and safety of surgical sympathetic blockade in systolic heart failure patients and secondary to assess its cardiovascular consequences.
- Conditions
- Systolic Heart Failure, Beta-blockers Intolerance, Beta-blockers Resistance
- Trial name
- SymBlock (NCT01224899)
- Testing
- Left cervico-thoracic sympathetic blockade
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Resistant Hypertension
The RESPLASH Study
To assess the safety and effectiveness of renal artery denervation with subsequent splanchnic nerves denervation via catheter-based radiofrequency ablation in improving blood pressure and glycemic control in patients with…
- Trial name
- NCT06880562
- Testing
- Splanchnic Nerve Denervation, Renal Denervation Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tulane University
Primary Aldosteronism Due to Aldosterone Producing Adenoma
Renal Sympathetic Denervation From The Adventitia on Hypertension
Renal sympathetic denervation from the intima of renal arteries has become an important method for the treatment of resistant hypertension, but renal sympathetic nerve are mainly located in the adventitia, and there is no report…
- Trial name
- RSDAH (NCT02642445)
- Testing
- Renal Sympathetic Denervation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Resistant Hypertension
Renal Sympathetic Denervation and Insulin Sensitivity (RENSYMPIS Study)
Hypertension is a major risk factor for stroke and cardiovascular mortality. Catheter- based renal denervation causes substantial and sustained blood- pressure reduction in patients with resistant hypertension.
- Trial name
- RENSYMPIS (NCT01785732)
- Testing
- Renal Denervation
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- The Hospital District of Satakunta