Clinical trials: Sympathetic Disorder
Heart Failure
Study of High Dosage of Losartan in Comparison to Low Dose of Losartan in Heart Failure Patients
The sympathetic nervous system, a part of the nervous system that stimulates the heart via release of substances, noradrenaline and adrenaline (combined called catecholamines), becomes activated in people with heart failure.
- Trial name
- NCT02238457
- Testing
- Low dose losartan, High dose losartan
- Sponsor
- Baker Heart and Diabetes Institute
Nervous System
Assessment of Sympathetic Nervous System Activity by Microneurography Recording Technique
Obesity is the consequence of an imbalance between energy intake and energy expenditure. Recent studies have suggested that the sympathetic nervous system (SNS) may be an important determinant of the rate of energy expenditure in…
- Trial name
- NCT00341770
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Stroke, Sympathetic Disorder
Contrast Bath and Sympathetic Skin Response
This study evaluates the effects of contrast bath on sympathetic skin response in stroke patients with complex regional pain syndrome .
- Trial name
- NCT04198532
- Testing
- Contrast bath
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Cataract
Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Tamsulosin
The purpose of this study is to determine whether corneal endothelium cell loss during cataract surgery is higher in patients taking Tamsulosin.
- Trial name
- NCT01076309
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Frederiksberg University Hospital
Heart Failure
Inspiratory Muscle Training Effectiveness in Sympathetic Activity and Functional Capacity in Patients With Heart Failure
Heart failure (HF) is configured major problem for public health in the country. Affected individuals may experience fatigue, dyspnea, respiratory muscle weakness, overstimulation of the sympathetic myocardial activity, among…
- Trial name
- NCT02600000
- Testing
- Myocardial scintigraphy, Cardiopulmonary test, AVD-Glittre Test
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Nightmare, Insomnia
INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention
The INSIGHT study is a multi-site clinical research program designed to examine how insomnia and symptoms of sympathetic hyperactivity impair sleep, cognition, and physiological restoration in warfighters, and to evaluate whether…
- Conditions
- Nightmare, Insomnia, PTSD, TBI
- Trial name
- INSIGHT (NCT07288593)
- Testing
- NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns.
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Stellate Ganglion Block
SGB Reduces the Incidence and Severity of CSA-AKI
The incidence of acute kidney injury after cardiopulmonary bypass cardiac surgery is high, which increases postoperative mortality and is not conducive to the prognosis of patients.
- Trial name
- NCT05652179
- Testing
- Stellate ganglion block
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Yangzhou University
Cardiovascular Disease
The Link Between the Clinical Resting Heart Rate and Sympathetic Overactivation
It is a retrospective study with no products limitation to investigate the link between clinical resting HR and SOA. Use HR≤60bpm as control group, compare other three groups with the control group and find out the correlation…
- Trial name
- NCT02315313
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
Coronary Heart Disease
Effect of Nicorandil on Cardiac Sympathetic Nerve for the Patients of Acute ST Segment Elevation Myocardial Infarction
The investigators evaluate the effects of intracoronary and intravenous administration of nicorandil on cardiac sympathetic nerve activity and distribution in patients with acute myocardial infarction undergoing primary…
- Trial name
- NCT04826497
- Testing
- nicorandil
- Volunteers
- 80 people
- Sponsor
- Xuzhou Central Hospital
Essential Hypertension
Heat Therapy in Older Hypertensive Women
The prevalence of hypertension is greater in older women than men, while the blood pressure (BP) control rate is lower in older women in US. Uncontrolled hypertension is a major risk factor for cardiovascular morbidity/mortality.
- Trial name
- NCT03857490
- Testing
- Lower leg heat therapy
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- University of Texas Southwestern Medical Center
Orthostatic Hypertension
Intravenous Norepinephrine for Orthostatic Hypotension
Background: Orthostatic hypotension is a fall in blood pressure when standing up. Normally, a reflex action of the automatic nervous system makes blood vessels tighten when people stand up.
- Trial name
- NCT01285908
- Testing
- Intravenous Norepinephrine Infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Sepsis, Lymphocyte Disorder T
Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes
Evaluate the effectiveness of esmolol, a selective β1-adrenergic receptor blocker, in modulating immune responses and improving patient outcomes in sepsis.
- Conditions
- Sepsis, Lymphocyte Disorder T, Immunologic Paralysis, Catecholamine; Overproduction
- Trial name
- NCT06390748
- Testing
- esmolol
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Lin Chen
Post-Traumatic Subarachnoid Hemorrhage
Superior Cervical Sympathetic Block Versus Stellate Ganglion Block in Post-traumatic Subarachnoid Hemorrhage
Posttraumatic Subarachnoid hemorrhage (SAH) is a life-threatening neurological problem with a high mortality rate. Delayed cerebral ischemia (DCI) is the second-leading cause of death and disability in patients suffering from…
- Trial name
- NCT06134583
- Testing
- Superior cervical sympathetic block group, Stellate ganglion block group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Kinesiophobia (Fear of Movement), Musculoskeletal Injuries
Binaural Beats Stimulation on the Autonomic Nervous System (ANS), Kinesiophobia and Fitness Levels in Professional Athletes With Musculoskeletal (MSK) Injuries
The purpose of the current study is to investigate the effectiveness of binaural beat stimulation on the autonomic nervous system (ANS), taking into account kinesiophobia related to reinjury and fitness levels in professional…
- Trial name
- ANS MSK HRV (NCT07370636)
- Testing
- Auditory stimulation with binaural beats and guidance, Auditory stimulation without binaural beats, Auditory stimulation with background music
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of West Attica
Pulmonary Edema
High Versus Low Dose Nitroglycerin in Acute Pulmonary Edema
The goal of this randomized controlled trial is evaluate the out come of: Low dose (< 100 mic/min )versus High dose (> 100 mic/min) of nitroglycerin in management of patients with acute pulmonary edema presented to Emergency…
- Trial name
- NCT06107465
- Testing
- Nitroglycerin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Spinal Cord Injury, Insulin Resistance
IR and Microvascular Blood Flow in SCI
Persons with spinal cord injury (SCI) are at an increased risk for metabolic disorders, including that of insulin resistance. As a result of neurological injury, they often have impaired mechanisms that regulate blood vessel…
- Trial name
- NCT02034331
- Testing
- Insulin iontophoresis, Acetylcholine Iontophoresis, Heat application
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study
The purpose of this study is to test the effect of oral melatonin supplementation (24 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114373
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabete Type 2, Heart Failure
Monitoring of the Sympathetic/Vagal Balance Through Multiparametric Analysis of Heart Rate Variability (HRV)
The autonomic nervous system (ANS) plays a crucial role in cardiovascular regulation by modulating heart rate in response to endogenous and environmental stimuli.
- Conditions
- Diabete Type 2, Heart Failure, Kidney Disease, Chronic, Cardiorenal Syndrome
- Trial name
- GLIFO-HRV (NCT07471802)
- Testing
- HOLTER ECG monitoring
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Restless Legs Syndrome, Neuropathic Pain
Spinal Cord Stimulation for Restless Legs Syndrome
The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS).
- Trial name
- NCT03539081
- Testing
- Dual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marshall Holland
Heart Failure
Using Clonidine to Improve Leg Weakness in People With Heart Failure
People with heart failure often have weakness in their leg muscles. This study will determine whether the leg weakness is due to very high adrenaline levels and whether the medication clonidine can improve leg weakness.
- Trial name
- NCT00858845
- Testing
- Clonidine Patch
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles