Clinical trials: Sympathetic Disorder
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Paroxysmal Sympathetic Hyperactivity
Effects of Early Musical Intervention on Prevalence and Severity of Paroxysmal Sympathetic Hyperactivity After Severe Traumatic Brain Injury
Paroxysmal sympathetic hyperactivity (PSH) is a frequent symptom after traumatic brain injury and concerns up to 30% of severely brain-injured patients.
- Trial name
- MUSIC-TCNV (NCT02783105)
- Testing
- Musical intervention, Control
- Where
- France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Strasbourg, France
Hypertension
Effect of Renal Denervation in End Staged Renal Disease With Resistant Hypertension
A. Hypertension is a major cardiovascular risk factor and numerous treatment strategies have been developed to treat hypertension properly and reduce cardiovascular risk. B.
- Trial name
- NCT02346045
- Testing
- Renal sympathetic denervation
- Where
- 4 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul St. Mary's Hospital
Major Depressive Disorder (MDD)
Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD)
There is strong evidence that patients with major depressive disorder (MDD) are at increased risk of developing coronary heart disease (CHD).
- Trial name
- NCT01483053
- Testing
- Agomelatine, Escitalopram
- Where
- 3 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Baker Heart and Diabetes Institute
Complex Regional Pain Syndrome (CRPS)
Efficacy and Safety of Intravenous Neridronic Acid in CRPS
The aim of this trial was to investigate the efficacy and safety of intravenous neridronic acid in subjects with Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT03530345
- Testing
- Neridronic acid 100 mg
- Where
- 71 sites in United States, Australia and 5 more
- Volunteers
- 182 people
- Sponsor
- Grünenthal GmbH
Chronic Kidney Disease
Vitamin-D Receptor Activation (VDRA) in Chronic Kidney Disease
To investigate whether treatment with a vitamin-D receptor activator is able to improve important markers of cardiovascular risk.
- Trial name
- SOLID (NCT01204528)
- Testing
- Zemplar
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Danderyd Hospital
Spinal Cord Injury
Measurement of Autonomic Cardiovascular Integrity in Persons With SCI
People with a spinal cord injury (SCI) have limited ability to move and feel sensation below the level of the SCI. Doctors and researchers have tests which determine the level of function and sensation, this test was developed by…
- Trial name
- NCT01758692
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Anesthesia, Local, Cerebral Vasospasm
Cervical Sympathetic Block in Patients With Cerebral Vasospasm
The purposes of this study are twofold: 1) to assess the effect of a cervical sympathetic block on cerebral blood flow in patients suffering from cerebral vasospasm, after aneurysmal subarachnoid hemorrhage; 2) to evaluate the…
- Conditions
- Anesthesia, Local, Cerebral Vasospasm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- NCT05230134
- Testing
- Cervical sympathetic block
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Autonomic Nervous System Disease, Healthy
Blood Sampling for Neurochemical and Genetic Testing
This study involves sampling blood from both normal volunteers and patients with diseases known or suspected to involve body chemicals called catecholamines.
- Conditions
- Autonomic Nervous System Disease, Healthy, Hypertension, Pheochromocytoma
- Trial name
- NCT00001147
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Abdominal Aortic Aneurysm
Relation betwEen Abdominal Aorta and Carotid Artery Responses to SymPathetic stimulatiON uSing duplEx Ultrasound
Abdominal aortic aneurysm (AAA) is a common vascular disease and associated with risk of rupture, but also with a high cardiovascular (CV) event rate. A key difficulty in AAA is predicting these life-threatening complications.
- Trial name
- RESPONSE (NCT04035252)
- Testing
- Carotid artery reactivity test (CAR-test)
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients
This is a Prospective, controlled, single-blind, randomized (2:1, Intervention:Control) clinical trial. The purpose of the study is to determine the role of adjunctive renal sympathetic denervation in the prevention of Atrial…
- Trial name
- NCT05988411
- Testing
- Renal Denervation, Catheter Ablation
- Where
- 8 sites in United States
- Volunteers
- 143 people
- Sponsor
- Vivek Reddy
Hypertension
Sympathetic Mapping/ Ablation of Renal Nerves Trial
To evaluate the safety and efficacy of targeted renal sympathetic denervation using SyMapCath I® and SYMPIONEER S1® Stimulator/ Generator in patients with essential hypertension for at least 6 months of the disease history and…
- Trial name
- SMART (NCT02761811)
- Testing
- SyMapCath I™ catheter and SYMPIONEER S1™ Stimulator/Generator
- Where
- 15 sites in China
- Volunteers
- 220 people
- Sponsor
- SyMap Medical (Suzhou), Ltd.
Microvascular Angina, Hypertension
Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris
The purpose of this study is to determine if long-term vasodilatory treatment is more effective than the standard treatment in hypertensive patients with microvascular angina pectoris
- Trial name
- NCT00424801
- Testing
- Lercanidipine, Valsartan, Nicorandil
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Intracranial Aneurysm, Intracranial Neoplasms
Esmolol Versus Dexmedetomidine During Intracranial Procedures
Patients undergoing intracranial procedures may experience severe hypertension and tachycardia due to intracranial hypertension and to increased release of adrenaline.
- Trial name
- NCT02563288
- Testing
- Esmolol, Dexmedetomidine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- George Papanicolaou Hospital
Fibromyalgia
Electrophysiological Findings in Fibromyalgia Patients
Fibromyalgia Syndrome (FMS); It is a chronic condition characterized by widespread body pain, sleep disturbance, fatigue, impaired cognitive functions, and anxiety (1).
- Trial name
- NCT04845737
- Testing
- sympathetic skin response measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Healthy, Vasodilation
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
- Conditions
- Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction
- Trial name
- NCT05153395
- Testing
- Carbon dioxide breathing, Neurovascular Coupling, Human insulin
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Cardiac Resynchronization Therapy, Heart Failure
Optimal Cardiac Resynchronization Therapy Pacing Rate
The optimal pacing rate during cardiac resynchronization therapy (CRT) is not known. Investigators investigate the impact of changing basal pacing frequencies on autonomic nerve function, cardiopulmonary exercise capacity and…
- Conditions
- Cardiac Resynchronization Therapy, Heart Failure, Bi-ventricular Pacing, Sympathetic Activity
- Trial name
- NCT02258061
- Testing
- DDD-80, DDD-60
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Heart Failure
Effect at 6 Months of Renal Denervation in Chronic Heart Failure d'Insuffisance Cardiaque
Management of chronic heart failure (CHF) is a major public health problem. It is associated with high mortality, frequent hospitalization and represents a large cost to the health care system.
- Trial name
- DENRENIC (NCT02471729)
- Testing
- EnligHTN™ Renal Denervation System
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Institute Arnault Tzanck, France