Clinical trials: Sympathetic Nervous System
Ovarian Cyst
Effects of Adrenergic Drugs on the Fluid Balance During Surgery
The aim this study was to examine to what degree the slow turnover of lactated Ringer's solution during anesthesia and surgery can be prevented by infusing esmolol (a ß1-receptor blocker) or phenylephrine in patients undergoing…
- Trial name
- NCT01431612
- Testing
- Esmolol administration, Phenylephrine infusion, Lactated Ringer´s solution
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sodertalje Hospital
Type I Complex Regional Pain Syndrome
Non Invasive Neurostimulation Technology for the Treatment of Type I Complex Regional Pain Syndrome (CRPS I)
Complex Regional Pain Syndrome (CRPS) / Complex Regional Pain Syndrome (CRPS) is a chronic neurological disorder that affects the extremities and is characterized by disabling pain, swelling, vasomotor instability, sudomotor…
- Trial name
- NCT05052736
- Testing
- Non-invasive Neuromodulation
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Las Palmas de Gran Canaria
Autonomic Nervous System Disease, Healthy
Study of Norepinephrine Levels and Sympathetic Nervous System Activity
Brain and nerve cells communicate with each other by releasing and picking up chemicals called neurotransmitters. Norepinephrine is a neurotransmitter used by part of the nervous system activated during stress called the…
- Conditions
- Autonomic Nervous System Disease, Healthy, Hypertension
- Trial name
- NCT00001329
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Improvement of Cardiovascular Autonomic Control, Reduction of Levels of Catecholamines
Acute Effect of Transcutaneous Electrical Nerve Stimulation in Heart Failure
The purpose of this study is to determine acute effect the transctutaneous electrical nerve stimulation in sympathetic and parassympathetic system in individuals with heart failure.
- Trial name
- TensIC (NCT01252407)
- Testing
- transcutaneous electrical nerve stimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Fibromyalgia
The Effect of Sympathetic Dysfunction on Muscle Spindle in Fibromyalgia
This study aims to reveal whether there is an impairment in the sympathetic regulation of muscle spindle sensitivity in patients with fibromyalgia syndrome (FMS).
- Trial name
- NCT05704374
- Testing
- sympathetic stimulation maneuver (mental arithmetic test, cold pressure test), Pregabalin 150mg
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Autonomic Nervous System Imbalance
Metabolism and the Activity of the Autonomic Nervous System in Patients With Paroxystic Sympathetic Hyperactivity, PSH
Adult patients suffering from acquired brain damage run the risk of developing PSH. This group of patients is admitted to our unit, the Neurointensive Stepdown Unit, at Silkeborg Regional Hospital for intensive care and early…
- Trial name
- MANS-PSH (NCT03441009)
- Testing
- Physio-/occupational therapy
- Volunteers
- 15 people
- Sponsor
- Region MidtJylland Denmark
Gestational Diabetes
Autonomic Nervous Activity in Women With Gestational Diabetes
Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al.
- Trial name
- NCT00867022
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Autonomic Peripheral Nervous System Diseases
Clinical Translation of 18F-Labeled Hydroxyphenethylguanidines
The purpose of this study is to perform first-in-human PET imaging studies of two new cardiac sympathetic nerve imaging agents, 4-[18F]fluoro-meta-hydroxyphenethylguanidine ([18F]4F-MHPG) and…
- Trial name
- NCT02385877
- Testing
- [18F]4F-MHPG, [18F]3F-PHPG
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Acute Brain Injury, Paroxysmal Sympathetic Hyperactivity
Initial Volume Status in Patients With Acute Brain Injury is Associated With Neurological Prognosis
In this study, we investigated the clinical variability in paroxysmal sympathetic hyperactivity in patients with acute brain injury and examined the prognostic value of the Paroxysmal Sympathetic Hyperactivity Assessment Measure…
- Conditions
- Acute Brain Injury, Paroxysmal Sympathetic Hyperactivity, Volume Status, Right Heart Function
- Trial name
- NCT06090812
- Testing
- Ultrasound evaluation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Menopause
Pilot Study - Impact of Traditional Acupuncture on Menopause
This pilot project is a randomized research study to examine the effects of acupuncture on menopausal symptoms. The investigators will recruit up to 45 Cedars employees (excluding Dr Bairey Merz's employees) with menopausal…
- Trial name
- NCT00950482
- Testing
- TA, AA, WC
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Fusion of Spine, Sympathetic Nervous System
Comparison of Surgical Outcomes Between Pre Sympathetic Plexus and Post Sympathetic Plexus Approach
There would be no difference in the risk of sympathetic plexus damage between the pre sympathetic plexus approach and the post sympathetic plexus approach.
- Trial name
- NCT04891432
- Testing
- Lateral lumbar interbody fusion
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Rosacea
Role of the Sympathetic Nervous System in Rosacea
Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause.
- Trial name
- NCT03989492
- Testing
- systemic and local stressors
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kristen Metzler-Wilson
Cardiovascular Diseases
Virtual Reality-based Therapy and Barriers in Cardiac Patients
The aim of this study is to investigate the chronic hemodynamic and autonomic repercussions of the insertion of VRBT in CR. To qualitatively analyze the perception of patients and physiotherapists regarding the use of VRBT, as…
- Trial name
- NCT04336306
- Testing
- virtual reality-based therapy (VRBT)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Menopause
Cortisol Levels on Menopausal Symptoms - Ancillary (Addendum) Study to Protocol 16997
This is an ancillary study to Protocol 16997 to examine the stress hormone level in women with menopausal symptoms. This ancillary project will collect additional data from the 45 subjects enrolled in Protocol 16997 (no subjects…
- Trial name
- NCT00950781
- Testing
- ACTH
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Upper Limb Nerve Block
The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance
Phase 1 Sympathetic block leads to vasodilatation and increases in blood flow. However, regional hemodynamic changes of radial and ulnar artery after specific nerve block of brachial plexus remains unclear.
- Trial name
- NCT02139982
- Testing
- specific nerve block, ropivacaine
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Wenzhou Medical University
Post Mastectomy Pain Syndrome, Chronic Pain Following Surgical Procedure for Cancer
Super-voltage PRF of Stellate Ganglion Versus Super-voltage PRF of T2 T3 Sympathetic Ganglia in Managing PMPS.
The aim of this study is to compare the effectiveness of super-voltage pulsed radiofrequency of stellate ganglion and super-voltage pulsed radiofrequency of T2-T3 sympathetic ganglia in the treatment of postmastectomy pain…
- Trial name
- PMPS PRF (NCT07675096)
- Testing
- Group S : Stellate Ganglion supervoltage pulsed radiofrequency, Group T : T2-T3 chains supervoltage pulsed radiofrequency.
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute, Egypt
Hypertension, Resistant, Sympathectomy
Procedural Sedation in Renal Sympathetic Denervation
This retrospective, single-center study investigates the effects of two different sedation regimens-dexmedetomidine versus fentanyl-propofol-on clinical outcomes in patients undergoing catheter-based renal sympathetic denervation…
- Conditions
- Hypertension, Resistant, Sympathectomy, Conscious Sedation, Procedural Sedation and Analgesia
- Trial name
- NCT07293273
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ebru Girgin Dinc
Diabetes Mellitus, Essential Hypertension
Doxazosin Effects on ABPM in Hypertensive Patients With Diabetic Nephropathy
Few studies have reported the effect of alpha1-adrenergic antagonists on 24-h blood pressure and regulation of sympathetic nervous activity in hypertensive patients with diabetic nephropathy.
- Conditions
- Diabetes Mellitus, Essential Hypertension, Renal Failure
- Trial name
- NCT00295555
- Testing
- Effects of doxazosin on morning surge in diabetic patients
- Where
- Japan
- Volunteers
- 98 people
- Sponsor
- Yokohama City University Medical Center
Chronic Kidney Diseases, Heart Failure
REducing Sympathetic Activity Through Ultrasound-based Renal deneRvation in Excessive Cardiovascular Risk populaTions.
The is a non-randomized pilot trial, open-label evaluation of the physiologic response of native kidney denervation using the Paradise denervation system in CKD, End Stage Renal Disease (ESRD), and Heart failure (HF)
- Conditions
- Chronic Kidney Diseases, Heart Failure, End Stage Renal Disease
- Trial name
- RESURRECT (NCT05703620)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 75 people
- Sponsor
- Royal Perth Hospital
Parkinson Disease, Neuroendocrine Tumors
124I-MIBG Tracer Evaluation of Myocardial Sympathetic Denervation and Assessment of Neuroendocrine Tumors.
The Feasibility of Novel 124I-MIBG Tracer in Evaluation of Myocardial Sympathetic Denervation and Assessment of Neuroendocrine tumors. Comparison with 123I-MIBG.
- Trial name
- NCT01931488
- Testing
- MIBG label with I123 or I124, SPECT imaging
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center