Clinical trials: Sympathetic Nervous System
Obesity, Hypertension
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease.
- Trial name
- NCT06482853
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Milton S. Hershey Medical Center
Healthy, Vasodilation
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
- Conditions
- Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction
- Trial name
- NCT05153395
- Testing
- Carbon dioxide breathing, Neurovascular Coupling, Human insulin
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Traumatic Brain Injury, Dysautonomia
Controlling Hyperadrenergic Activity in Neurologic Injury
Traumatic brain injury (TBI) is frequently associated with a hyperadrenergic state accompanied by elevated levels of plasma catecholamines.
- Trial name
- CHAIN (NCT01343329)
- Testing
- Esmolol, Propranolol
- Where
- United States
- Sponsor
- Johns Hopkins University
Complex Regional Pain Syndrome Type 1
Intravenous Immunoglobulins in Complex-regional Pain Syndrome
The purpose of this study is to determine whether intravenous immunoglobulins are effective in the treatment of complex-regional pain syndrome.
- Trial name
- PAINLESS (NCT00949065)
- Testing
- intravenous immunoglobulins
- Where
- Germany
- Sponsor
- University of Giessen
Major Depressive Disorder (MDD)
Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD)
There is strong evidence that patients with major depressive disorder (MDD) are at increased risk of developing coronary heart disease (CHD).
- Trial name
- NCT01483053
- Testing
- Agomelatine, Escitalopram
- Where
- 3 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Baker Heart and Diabetes Institute
Vasoconstriction, Healthy
Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction
The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.
- Conditions
- Vasoconstriction, Healthy, Insulin Resistance
- Trial name
- NCT05244694
- Testing
- Insulin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Type 2 Diabetes Mellitus
Brown Adipose Tissue and Body Mass Index
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between…
- Trial name
- NCT02173834
- Testing
- 18F- fluorodeoxyglucose-positron emission tomography Computed Tomography scan and 123I-metaiodobenzylguanidine-single-photon emission computed tomography scan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Physical Activity, Sympathetic Nervous System
Neuropeptide Y and Sympathovagal Balance
Neuropeptide Y (NPY) activates the sympathetic and vagal nervous systems through the Y1 and Y2 receptors. This double-blind placebo-controlled crossover study investigated the sympathovagal balance during three exercises on a…
- Conditions
- Physical Activity, Sympathetic Nervous System, Secretion; Catecholamine
- Trial name
- NPY (NCT03933787)
- Testing
- Saxagliptin 5mg, ergometric test in healthy volunteers
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Eric Grouzmann
Hypertension, Stress, Psychological
Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress
High blood pressure, or hypertension, is a serious problem in the African-American (AA) population which affects nearly 7 of every 10 AAs in our area.
- Conditions
- Hypertension, Stress, Psychological, Blood Pressure
- Trial name
- NCT02431936
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augusta University
Reflex Sympathetic Dystrophy
Investigation of the Efficacy of tDCS in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1
The efficacy of the current standard non-pharmacological treatments for complex regional pain syndrome (CRPS), a painful syndrome mostly occurring after musculoskeletal trauma, is suboptimal.
- Trial name
- NCT01960400
- Testing
- Graded motor imagery (GMI)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Université de Sherbrooke
Nightmare, Insomnia
INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention
The INSIGHT study is a multi-site clinical research program designed to examine how insomnia and symptoms of sympathetic hyperactivity impair sleep, cognition, and physiological restoration in warfighters, and to evaluate whether…
- Conditions
- Nightmare, Insomnia, PTSD, TBI
- Trial name
- INSIGHT (NCT07288593)
- Testing
- NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns.
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Hypertension, Renal Denervation
The Predictive Role of Proteomics in Blood Pressure Response of Hypertensive Patients Undergoing Renal Denervation.
Renal sympathetic nervous activity plays a crucial role in the development and maintenance of hypertension (HTN). Renal denervation (RDN) is a minimally invasive catheter-based treatment using mainly radiofrequency or ultrasound…
- Conditions
- Hypertension, Renal Denervation, Proteomics
- Trial name
- PREDICT-RDN (NCT06208501)
- Testing
- Urine sample for proteomic analysis, ABPM, OBPM
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Hippocration General Hospital
Ovarian Cyst
Effects of Adrenergic Drugs on the Fluid Balance During Surgery
The aim this study was to examine to what degree the slow turnover of lactated Ringer's solution during anesthesia and surgery can be prevented by infusing esmolol (a ß1-receptor blocker) or phenylephrine in patients undergoing…
- Trial name
- NCT01431612
- Testing
- Esmolol administration, Phenylephrine infusion, Lactated Ringer´s solution
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sodertalje Hospital
Essential Hypertension
The Effect of Eprosartan on Hormones and Kidney Function in Patients With Essential Hypertension
We, the investigators at Holstebro Hospital, want to test the hypothesis that eprosartan reduces the activity of the sympathetic nervous system in patients with essential hypertension - during baseline conditions and after…
- Trial name
- NCT00438945
- Testing
- Eprosartan
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Regional Hospital Holstebro
Chronic Pain (Back / Neck), Autonomic Dysregulation
Autonomic Recalibration
The goal of this clinical trial is to learn if Autonomic Recalibration works to reduce sympathetic dominance to alleviate dysfunctional myofascial pain.
- Trial name
- ART (NCT06603168)
- Testing
- Autonomic Recalibration Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Post-traumatic Stress Disorder
Clinical Study About the Effects of Scuba Diving on Post Traumatic Stress Disorder (PTSD)
Post-traumatic stress disorder (PTSD) is a set of symptoms that can be developed as a result of exposure to a traumatic event or events that can range in prevalence from 25% to 75%.
- Trial name
- DIVE4NICE (NCT04343924)
- Testing
- Scuba diving activities, Virtual reality activities
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Neuralgia, Postherpetic Neuralgia
Effects of Pennsaid on Clinical Neuropathic Pain
The purpose of this study is to see if the drug Pennsaid (Diclofenac) can help reduce pain felt by people with chronic nerve pain. The drug will be used 2-4 times each day for 2 weeks. The U.S.
- Conditions
- Neuralgia, Postherpetic Neuralgia, Reflex Sympathetic Dystrophy, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01508676
- Testing
- Pennsaid
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Unrecognized Condition
Deep Diaphragmatic Breathing: Neurobiological and Anti-inflammatory Effects
The exposure to acute and\or chronic stress can produce an activation of sympathetic nervous system (SNS), leading to an increased level of cortisol and pro-inflammatory cytokines.
- Trial name
- NCT04102813
- Testing
- Functional Therapy
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Spinal Cord Injuries (SCI), Spinal Cord Injury
Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.
Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Injury
- Trial name
- NCT07692191
- Testing
- Transcutaneous spinal electrical stimulation (TSES)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Nervous System
Assessment of Sympathetic Nervous System Activity by Microneurography Recording Technique
Obesity is the consequence of an imbalance between energy intake and energy expenditure. Recent studies have suggested that the sympathetic nervous system (SNS) may be an important determinant of the rate of energy expenditure in…
- Trial name
- NCT00341770
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)