Clinical trials: Sympathetic Nervous System
Uveitis, Intermediate Uveitis
Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis
This study is designed to determine the safety and tolerability of a single microinjection of triamcinolone acetonide (TRIESENCE®) into the suprachoroidal space (SCS) of patients who have non-infectious uveitis.
- Conditions
- Uveitis, Intermediate Uveitis, Posterior Uveitis, Panuveitis
- Trial name
- NCT01789320
- Testing
- triamcinolone acetonide (Triesence®)
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Clearside Biomedical, Inc.
Complex Regional Pain Syndrome, Postherpetic Neuralgia
Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block
This study compares the efficacy of the ultrasound with fluoroscope in guidance of lumbar sympathetic block (LSB). The goals of the study are; 1) To show that US-guided LSB results in shorter performance time compared to…
- Conditions
- Complex Regional Pain Syndrome, Postherpetic Neuralgia, Diabetic Polyneuropathy, Peripheral Neuropathy
- Trial name
- NCT02737527
- Testing
- 24G intravenous route for Lumbar Sympathetic Block (LSB):, 15-cm Chiba needle for Lumbar Sympathetic Block (LSB), Ultrasound for Lumbar Sympathetic Block (LSB)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University
Orthostatic Hypotension, Spinal Cord Injury
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure.
- Trial name
- NCT00426842
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Insulin Resistance, Healthy
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake.
- Conditions
- Insulin Resistance, Healthy, Obesity
- Trial name
- NCT03318094
- Testing
- Phentolamine, Saline, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Complex Regional Pain Syndrome Type I of the Upper Limb
Single-port Thoracoscopic Sympathicotomy in Complex Regional Pain Syndrome Type I (CRPS)
Background of the study: CRPS type-1 is a pain syndrome that usually develops after an initiating noxious event (e.g. fracture) in an extremity.
- Trial name
- NCT01886625
- Testing
- unilateral single-port VATS sympathicotomy
- Where
- Netherlands
- Sponsor
- University of Groningen
Metabolic Syndrome, Obesity
Cortisol and Nutritional Sympathetic Responsiveness
This project will examine whether short-term (over a 12-hour period) pharmacological lowering of the stress hormone 'cortisol' improves the nervous system response to food intake in overweight or obese individuals who have…
- Conditions
- Metabolic Syndrome, Obesity, Insulin Resistance
- Trial name
- NCT01620684
- Testing
- metyrapone
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Baker Heart Research Institute
Hyperhidrosis, Children, Adolescents
Thoracoscopic Sympathetic Chain Interruption for Palmar Hyperhidrosis in Patients Below 18
In this study, the investigators aim to present fifteen years' experience of thoracoscopic sympathetic chain interruption for primary palmar hyperhidrosis in children and adolescents; evaluation of 3 different techniques…
- Conditions
- Hyperhidrosis, Children, Adolescents, Thoracoscopic Sympathetic Chain Interruption, Sympathetic Disorder
- Trial name
- MISforPPH (NCT06113978)
- Testing
- Thoracoscopic sympathectomy, Thoracoscopic sympathotomy, Thoracoscopic sympathetic chain clipping
- Where
- Egypt
- Volunteers
- 420 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Healthy, Obesity
Effect of Ghrelin on Sympathetic Nervous System
Ghrelin is a newly discovered peptide that is secreted by the stomach. Its main role is to stimulate food intake but recent studies indicate that it also acts on the cardiovascular system to confer beneficial effects.
- Trial name
- NCT00912587
- Testing
- ghrelin
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
Leiomyoma
Vascular Function and Uterine Fibroids
The purpose of this study is to learn how uterine fibroids may be connected to heart disease and high blood pressure. It is not known what causes fibroids, but they frequently occur in women who also have high blood pressure…
- Trial name
- NCT02123069
- Testing
- Brachial artery catheter, Acetylcholine, Nitroprusside
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Complex Regional Pain Syndrome, Type I
Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1
The purpose of this multicenter, double-blind, placebo-controlled study is to evaluate the efficacy and safety of Lenalidomide in adult subjects with Complex Regional Pain Syndrome (CRPS) Type 1.
- Trial name
- CRPS-002 (NCT00109772)
- Testing
- lenalidomide
- Where
- 27 sites in United States
- Volunteers
- 184 people
- Sponsor
- Celgene Corporation
Heart Failure, Obstructive Sleep Apnea
ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
Obstructive sleep apnea (OSA), central sleep apnea (CSA) and heart failure (HF) are states of metabolic demand and sympathetic nervous system (SNS) activation.
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Central Sleep Apnea
- Trial name
- AMEND (NCT02116140)
- Testing
- [C11]Acetate and HED PET
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiac Disease, Risk Factor, Cardiovascular
Virtual Reality Based-therapy Applied to Physical Therapy in Cardiology.
The aim of this study is to investigate engagement, motivation, and the barriers to adherence of virtual reality based therapy (VRBT) in patients with cardiac diseases and risk factors to the development of cardiac diseases.
- Trial name
- NCT03377582
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 68 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
End-stage Renal Disease (ESRD), Kidney Disease
Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis
Hypothesis: Patients starting peritoneal dialysis with a glucose-based regimen have high sympathetic activity in response to an increase in leptin and insulin.
- Trial name
- SAPD (NCT01228279)
- Testing
- DIANEAL, EXTRANEAL
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Rheumatoid Arthritis
Role of the ANS Dysregulation in the Persistence of Fatigue in Rheumatoid Arthritis Patients Treated With Anti-TNF
Despite the large therapeutic arsenal available since one decade allowing a strong reduction of inflammation process, rheumatoid arthritis (RA) patients claimed pain, fatigue, sleep problems and other quality of life outcomes.
- Trial name
- ANSRA (NCT02475486)
- Testing
- VistaO2
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cardiac Output, Low
Cardiac Output Autonomic Stimulation Therapy for Heart Failure (COAST-HF) - Human NeuroCatheter Study
A single-center feasibility study in patients undergoing cardiac catheterization, to investigate the acute hemodynamic effects of transvenous cardiac autonomic nerve stimulation.
- Trial name
- COAST-HF HNrCS (NCT02880683)
- Testing
- NeuroTronik CANS Therapy System
- Where
- Paraguay
- Volunteers
- 16 people
- Sponsor
- NeuroTronik Inc.
Sepsis, Septic Shock
Early Dexmedetomidine and Sympathetic Regulation in Sepsis
The goal of this clinical trial is to learn whether early administration of dexmedetomidine can improve autonomic nervous system regulation and clinical outcomes in adult patients with septic shock.
- Trial name
- DEX-SNS-SEPSIS (NCT07470775)
- Testing
- Dexmedetomidine (DEX)
- Volunteers
- 168 people
- Sponsor
- Sichuan Academy of Medical Sciences
Restless Legs Syndrome, Neuropathic Pain
Spinal Cord Stimulation for Restless Legs Syndrome
The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS).
- Trial name
- NCT03539081
- Testing
- Dual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marshall Holland
Apical Ballooning Syndrome, Nervous System Diseases, Sympathetic
Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy
Stress (tako-tsubo) cardiomyopathy (SC) is a rapidly reversible form of acute heart failure reported to be triggered by stressful events and associated with a distinctive left ventricular (LV) contraction pattern.
- Trial name
- NCT01524861
- Testing
- alpha-lipoic acid, L-acetyl carnitine
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Campania Luigi Vanvitelli
Therapy-resistant Hypertension and Sleep Apnea
Effect of Catheter-based Radiofrequency Ablation Therapy in Patient With Therapy-resistant Hypertension and Sleep Apnea Syndrome
The aim of this prospective single-center study is to evaluate sympathetic nervous system directly measured by microneurography, 24-hour blood pressure, endothelial function, vascular compliance, quality of life and platelet…
- Trial name
- NCT01879566
- Testing
- No intervention will be done. The study is observational
- Where
- Switzerland
- Sponsor
- University of Zurich
Spinal Cord Injury, Autonomic Dysreflexia
Treatment of Post-SCI Hypotension
While treatment strategies for OH have been identified for use in persons with acute SCI, the field of SCI medicine lacks a gold standard for treatment thresholds and well-defined outcome parameters.
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Orthostatic Hypotension, Baroreceptor Integrity
- Trial name
- NCT02919917
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center