Clinical trials: Sympathetic Nervous System
Metabolic Syndrome, Type 2 Diabetes Mellitus
Effects of Sodium-glucose Co-transporter-2( SGLT-2 ) Inhibition on Sympathetic Nervous System Activity in Humans
This study is designed to investigate whether the sodium-glucose co-transporter-2 (SGLT-2) inhibitor Empagliflozin reduces sympathetic nervous system (SNS) activity in humans.
- Conditions
- Metabolic Syndrome, Type 2 Diabetes Mellitus, Obesity
- Trial name
- EMPA-SNS (NCT03912909)
- Testing
- Empagliflozin Oral Tablet [Jardiance]
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Royal Perth Hospital
Spinal Cord Injury
Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury
As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced…
- Trial name
- NCT01984476
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Catecholamine; Overproduction, Catecholamine; Secretion
Sympathetic Activity and Cardiometabolic Complications
Recent studies on catecholamine physiology have shown a direct correlation with arterial hypertension, overcoming the exclusive role in the diagnosis and follow-up of chromaffin tumors.
- Conditions
- Catecholamine; Overproduction, Catecholamine; Secretion, Metabolic Syndrome, Hypertensive Heart Disease
- Trial name
- SYMPACT (NCT04495231)
- Where
- Italy
- Volunteers
- 1,380 people
- Sponsor
- University of Turin, Italy
Stress, Psychological, Inflammation
Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?
This randomized, double-blind, placebo-controlled study of propranolol will shed important light on how sympathetic nervous system (SNS) activation influences psychological and inflammatory responses to acute stress.
- Conditions
- Stress, Psychological, Inflammation, Cortisol, Sympathetic Nervous System
- Trial name
- NCT02972554
- Testing
- Propanolol hydrochloride
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Spinal Cord Injury, Autonomic Dysreflexia
Treatment of Post-SCI Hypotension
While treatment strategies for OH have been identified for use in persons with acute SCI, the field of SCI medicine lacks a gold standard for treatment thresholds and well-defined outcome parameters.
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Orthostatic Hypotension, Baroreceptor Integrity
- Trial name
- NCT02919917
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Complex Regional Pain Syndrome
Safety of Intravenous Neridronic Acid in CRPS
The aim of this trial was to investigate the safety of intravenous neridronic acid in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT02972359
- Testing
- Neridronic acid
- Where
- 46 sites in United States, Germany
- Volunteers
- 580 people
- Sponsor
- Grünenthal GmbH
Obesity, Hypertension
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease.
- Trial name
- NCT06482853
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Milton S. Hershey Medical Center
Vasoconstriction, Healthy
Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction
The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.
- Conditions
- Vasoconstriction, Healthy, Insulin Resistance
- Trial name
- NCT05244694
- Testing
- Insulin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Migraine Disorders
Defining the Sympathetic Skin Response of Migraineurs in the Facial Area
The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation…
- Trial name
- NCT03772860
- Testing
- Pain stimulation, Visual stimulation, Auditory stimulation
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Autonomic Nervous System Activity
Vagotonic Effect of Remifentanil and Autonomic Nervous System Activity.
Remifentanil (RMFNT) is a very short active opioid, used for analgesia during general anaesthesia and for analgesic and sedative effect in intensive care units (ICU) patients.
- Trial name
- NCT01714388
- Testing
- Remifentanil
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Gdansk
Hypotension, Orthostatic, Hypertension
Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
Neurogenic Orthostatic Hypotension (NOH) is clinically defined as a consistent drop in systolic blood pressure (SBP) ≥30mmHg upon standing from a seated or lying position.
- Conditions
- Hypotension, Orthostatic, Hypertension, Autonomic Nervous System Diseases
- Trial name
- NCT02963181
- Testing
- Yohimbine, Melatonin
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Plasma Exchange, Autonomic Failure
Plasma Exchange for Autoimmune Autonomic Failure
This study will explore whether an antibody is influencing the autonomic nervous system, and if its removal will eliminate signs and symptoms of failure in that system.
- Trial name
- NCT00359346
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Metabolic Syndrome
Effects of Pioglitazone Treatment on Sympathetic Nervous System Function in Metabolic Syndrome Obesity
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin cluster in these individuals.
- Trial name
- NCT00408850
- Testing
- Pioglitazone, sugar pill
- Where
- Australia
- Volunteers
- 44 people
- Sponsor
- Baker Heart Research Institute
Heart Failure
Clinical Assessment of the Treatment With Cardiac Sympathetic Blockade on Chronic Heart Failure
The purpose of this study is to evaluate the effect of Cardiac Sympathetic Blockade on Mortality, re-hospitalization rate, symptoms, quality of life, exercise tolerance, cardiac structure, systolic function, electrical activities…
- Trial name
- CSB-CHF (NCT02391142)
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Diabetes Mellitus, Type 2
Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects
The objective of this early feasibility study is to evaluate the safety and performance of intravascular hepatic denervation using the Metavention Integrated Radio Frequency Denervation System (iRF System) to improve glycemic…
- Trial name
- DeLIVER (NCT04285554)
- Testing
- iRF System Hepatic Denervation
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Metavention
Cardiovascular Diseases
Loneliness and Social Connection in Cardiovascular Disease
The study evaluates the impact of vulnerable self-disclosure and perceived responsiveness in individuals across levels of loneliness. Participants will be randomized to a high disclosure or a low disclosure condition.
- Trial name
- NCT04195620
- Testing
- High self-disclosure, Low self-disclosure
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Morehead State University
Diabetic Nephropathies
Sympathetic Nervous System Inhibition for the Treatment of Diabetic Kidney Disease
The purpose of this study is to determine whether moxonidine is effective in reducing urine albumin levels in patients with diabetic kidney disease.
- Trial name
- NCT01094769
- Testing
- Moxonidine
- Where
- Australia
- Volunteers
- 48 people
- Sponsor
- Baker Heart and Diabetes Institute
Benign Paroxysmal Positional Vertigo, Vertigo
The Cardiac Autonomic Control System Response to Vestibular Stimulation in Subjects With and Without BPPV
The vestibular system in the inner year is an important system in the body which is responsible for balance. In addition, there is evidence that the vestibular system plays a role in maintaining blood pressure while changing body…
- Conditions
- Benign Paroxysmal Positional Vertigo, Vertigo, Autonomic Nervous System
- Trial name
- NCT03867019
- Testing
- Heart rate variability parameters monitoring
- Where
- Israel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Obesity, Abdominal
The Impact Of An Intermittent Energy Restricted Diet On Insulin Sensitivity In Men and Women With Central Obesity
An intermittent energy restricted (IER) diet may modify cardio-metabolic disease risk factors compared to an energy-matched continuous energy restricted (CER) diet.
- Trial name
- Met-IER (NCT02679989)
- Testing
- Intermittent Energy Restriction, Continuous Energy Restriction
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King's College London