Clinical trials: Symptom
Chronic Myelogenous Leukemia, Chronic Myeloid Leukemia
Dasatinib or Nilotinib Followed by Imatinib in Patients With Newly Diagnosed, Chronic Phase Chronic Myeloid Leukemia
This phase II trial studies how well dasatinib, nilotinib, and imatinib mesylate works in treating patients with newly diagnosed, previously untreated chronic myeloid leukemia in which fewer than 10% of the cells in the blood and…
- Conditions
- Chronic Myelogenous Leukemia, Chronic Myeloid Leukemia, Leukemia
- Trial name
- NCT02709083
- Testing
- Dasatinib, Imatinib Mesylate, Nilotinib
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Emory University
Mucopolysaccharidosis I, Mucopolysaccharidosis II
Clinical Trial of Growth Hormone in MPS I, II, and VI
The purpose of this study is to determine whether growth hormone is a safe and effective treatment for short stature in children with Mucopolysaccharidosis type I, II, and VI.
- Conditions
- Mucopolysaccharidosis I, Mucopolysaccharidosis II, Mucopolysaccharidosis VI
- Trial name
- NCT00748969
- Testing
- Somatropin (DNA origin)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Cardiovascular Risk Factor, Prediabetes
Active You: A Novel Exercise Program for African Americans
Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04280783
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Low Back Pain
Efficacy and Safety of FIRTECH in Patients With Mild to Moderate Acute Low Back Pain
Primary Objective: To assess the efficacy of the infrared therapy patch (ITP) FIRTECH for treating participants suffering from mild to moderate acute low back pain.
- Trial name
- IRPATCH (NCT05137041)
- Testing
- ITP FIRTECH
- Where
- 7 sites in Germany, Italy
- Volunteers
- 221 people
- Sponsor
- Sanofi
Breast Neoplasms, Neoplasm Metastasis
Study Evaluating SKI-606 (Bosutinib) In Subjects With Breast Cancer
The purpose of this study is to determine if SKI-606 (Bosutinib) is effective in the treatment of advanced or metastatic breast cancer.
- Trial name
- NCT00319254
- Testing
- SKI-606 (Bosutinib)
- Where
- 15 sites in United States, Australia and 6 more
- Volunteers
- 75 people
- Sponsor
- Pfizer
Major Depressive Disorder, Anxiety
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms
The purpose of this study is to investigate the efficacy and safety of flexibly dosed adjunctive brexpiprazole treatment in subjects with major depressive disorder and anxiety symptoms, who are experiencing an inadequate…
- Trial name
- NCT02013531
- Testing
- Brexpiprazole
- Where
- 21 sites in United States
- Volunteers
- 37 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Kidney Failure, End Stage Renal Disease
Enhancing the Cardiovascular Safety of Hemodialysis Care (Dialysafe)
The purpose of this study is reduce episodes of intradialytic hypotension, low blood pressure during a hemodialysis session, in patients with End Stage Renal Disease (ESRD).
- Conditions
- Kidney Failure, End Stage Renal Disease, Hypotension, Cardiovascular Diseases
- Trial name
- Dialysafe (NCT03171545)
- Testing
- Patient Activation, Provider Education
- Where
- United States
- Volunteers
- 1,431 people
- Sponsor
- University of Michigan
Diabetes
Jump Start Shared Medical Appointments for Diabetes With Weight Management
The proposed research will test a novel program that combines intensive weight management with shared (group) medical appointments for patients with diabetes.
- Trial name
- Jump Start (NCT01973972)
- Testing
- Weight management, Shared medical appointments (SMA)
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- VA Office of Research and Development
Caffeine Dependence, Anxiety
Remote Guided Caffeine Reduction
The purpose of this online research study is to determine whether or not a gradual caffeine reduction program developed at Johns Hopkins can help people reduce their caffeine use.
- Conditions
- Caffeine Dependence, Anxiety, Sleep Disturbance, Gastrointestinal Dysfunction
- Trial name
- NCT04560595
- Testing
- Caffeine Reduction Manual
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sexually Transmitted Diseases, Reproductive Behavior
Enhanced SexHealth Intervention to Improve Adolescent Outcomes
This is an adaptive trial with an initial Formative Revision Process followed by a Randomized Controlled Trial (RCT). Up to 500 adolescents will be consented into this study to achieve 6 completed subjects for the formative…
- Trial name
- NCT03341975
- Testing
- SexHealth
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Sleep Disorders
Non-Pharmacological Interventions on Sleep in Post-Acute Rehabilitation
This project is a randomized controlled trial to test whether a multicomponent, nonpharmacological intervention improves sleep/wake patterns and functional recovery among older people undergoing post-acute rehabilitation.
- Trial name
- NCT00333619
- Testing
- Nonpharmacological sleep intervention, Active control
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- US Department of Veterans Affairs
Pain
Effects of Perioperative B&O Suppositories on Post-op Pain and Morphine Use After Laparoscopic Prostatectomy
This study is evaluating the effect of a Belladonna and Opium suppository administered intraoperatively on post operative pain after laparoscopic radical prostatectomy for prostate cancer. This is a blinded randomized study.
- Trial name
- NCT00863928
- Testing
- belladonna 16.2 mg and opium 60 mg suppository
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Benaroya Research Institute
Constipation
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adolescent Subjects
The objective of this study is to evaluate the safety and efficacy of BLI400 laxative in constipated adolescent subjects.
- Trial name
- NCT02665728
- Testing
- BLI400 Laxative
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Braintree Laboratories
Tourette Syndrome, Tic Disorder, Chronic Motor or Vocal
Open-label MNS for Tourette Syndrome
A recent report (Morera Maiquez et al 2020) described reduced tic severity in people with Tourette syndrome during 1-minute epochs of median nerve stimulation (MNS) at 10 Hz.
- Trial name
- NCT05016765
- Testing
- Active, self-directed electrical stimulation of the median nerve
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Aging, Aphasia
Exercise Effects on Word Learning
The aging Veteran population will substantially increase over the next 10 years, as the 24.9% of Veterans who are currently between 55-64 years of age join the 38.5% who are already over age 65.
- Trial name
- NCT03370471
- Testing
- Retrieval Practice + Moderate Intensity Exercise, Retrieval Practice + Gentle Stretching, Study Only + Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
IUGR, Fetal Growth Retardation
Cardiac Displacement From Third Trimester to Early Childhood
The aim is to increase awareness of the relationship between (IUGR) and cardiac function in the foetus, the development of cardiac function over time after delivery and what significance a possible early disturbed myocardial…
- Conditions
- IUGR, Fetal Growth Retardation, Intrauterine Growth Restriction
- Trial name
- CADETTE (NCT02583763)
- Testing
- Echocardiography, Blood sample
- Where
- 2 sites in Sweden
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Nausea
Alternative Approaches for Nausea Control
216 Chemotherapy-naïve, female breast cancer patients about to begin chemotherapy and who expect to have nausea, will be entered.
- Trial name
- NCT01695993
- Testing
- Acupressure bands, Expectancy-neutral handout, Expectancy-neutral MP3
- Where
- 4 sites in United States
- Volunteers
- 242 people
- Sponsor
- University of Rochester
Breast Neoplasm Female
THRIVE Breast Cancer App Study
This study will test the use of a web-enabled app that is integrated directly with patients' electronic health records, with and without tailored feedback.
- Trial name
- THRIVE (NCT03592771)
- Testing
- THRIVE App, Tailored Feedback Messages
- Where
- 2 sites in United States
- Volunteers
- 304 people
- Sponsor
- Emory University
Peri-implantitis
The Efficacy and Safety of Chlorhexidine Gluconate Chip (Periochip®) in Therapy of Symptoms in Patients With Peri-implantitis
The purpose of the study is to assess the efficacy and the safety of Chlorhexidine Gluconate chip (Periochip®) versus Placebo Chip in treatment of symptoms in patients with Peri-Implantitis.
- Trial name
- NCT01079663
- Testing
- Chlorhexidine 2.5 mg
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Dexcel Pharma Technologies Ltd.
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