Clinical trials: Symptom
Burnout, Professional
Creating Healthy Work Places (HWP) Study
The health of the public depends upon smoothly functioning physician offices that promote the health of both workers and their patients. This study targets ambulatory health care offices with rapid paced, chaotic environments.
- Trial name
- HWP (NCT02542995)
- Testing
- QI interventions
- Volunteers
- 1,296 people
- Sponsor
- Hennepin Healthcare Research Institute
Ventral Hernia
AFFIX: Post-market Study of MaxTack™ Motorized Fixation Device in Subjects Undergoing Ventral Hernia Repair
Medtronic is sponsoring and funding the AFFIX study, a prospective, post-market, multicenter, nonrandomized, single-arm, interventional clinical study.
- Trial name
- AFFIX (NCT06710795)
- Testing
- MaxTack™ Motorized Fixation Device
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Medtronic - MITG
Chronic Pain
Telehealth Therapy for Chronic Pain: Comparison of In-person vs. Video-administered ACT for Pain
The purpose of the study is to test a brief, individual psychosocial in-person or telehealth intervention to reduce interference of pain with daily life, emotional distress, and pain intensity, and improve quality of life and…
- Trial name
- TTCP (NCT01055639)
- Testing
- In-Person ACT, Telehealth ACT
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Breast Pain
Post Mastectomy Pain Syndrome After Preoperative Stellate Ganglion Block for Breast Cancer Surgeries
This study investigate the effect of pre-operative ultrasound guided stellate ganglion block with local anesthetic on the frequency of neuropathic pain syndromes in the first 6-month post cancer breast surgeries with axillary…
- Trial name
- NCT04238377
- Testing
- Stellate Ganglion Block, Multimodal Analgesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute, Egypt
Microbiome,Immune Function, Critically Ill
Microecology and Host Immunity in Patients With Severe COVID-19 Infection
The purpose of this study was to analyze the relationship between the microbial community, host immunity and the prognosis of patients with severe COVID-19.
- Trial name
- NCT05670275
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Obesity, Overweight
Program for the Comprehensive Neurocognitive Treatment of Excess Weight
The present study aims to determine the effectiveness of a comprehensive neurocognitive program for the treatment of excess weight.
- Trial name
- TRAINEP (NCT05158075)
- Testing
- Approach-Avoidance Bias Modification, Inhibition Training, Implementation of Intentions
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Raquel Vilar López
Depression
Comparing Clinical Decision-making of AI Technology to a Multi-professional Care Team in ECBT for Depression
Depression is a leading cause of disability worldwide, affecting up to 300 million people globally. Despite its high prevalence and debilitating effects, only one-third of patients newly diagnosed with depression initiate…
- Trial name
- NCT05648175
- Testing
- e-CBT, e-CBT + Phone Call, e-CBT + Phone Call + Pharmacotherapy
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- Dr. Nazanin Alavi
Pulmonary Disease, Chronic Obstructive
Assessment of Physical Functioning and Handling of Spiolto Respimat in Patients With COPD (OTIVACTO)
The primary objective of this Non Interventional Study is to measure changes in physical functioning, a surrogate for physical activity and exercise capacity, in COPD patients on treatment with Spiolto® Respimat® in routine daily…
- Trial name
- NCT02720757
- Testing
- Spiolto Respimat
- Where
- 6 sites in Belgium, Denmark and 4 more
- Volunteers
- 132 people
- Sponsor
- Boehringer Ingelheim
Periodontitis, Adult
Cleansing Efficacy of Waist-shaped Interdental Brushes.
The aim of the present randomized and single-blinded cross-over study was to compare the cleansing efficacy of waist-shaped interdental brushes with that of cylindric interdental brushes in interproximal sites.
- Trial name
- Waist-shaped (NCT03851757)
- Testing
- waist-shaped interdental brush, cylindric interdental brush
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University Innsbruck
COPD
High Flow Nasal Cannula and Hypercapnia
In the present investigation, in 50 COPD with persistent hypercapnia after an acute exacerbation, the investigators want to assess the acceptability of HFNC and its effectiveness in further reducing the level of PaCO2, and to…
- Trial name
- NCT03759457
- Testing
- High Flow Nasal Cannula (AIRVO2)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Depression
Mindfulness Training During Accelerated TMS for Depression
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically…
- Trial name
- NCT07369557
- Testing
- Guided Mindfulness Practice using a study created web app that links to the commercially available Waking Up app
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Cardiac Disease, Cardiopulmonary Disease
World Trade Center (WTC) RENAL
Environmental toxins exert damaging health effects in workers. Thousands of responders who worked or volunteered on the World Trade Center (WTC) rescue and recovery effort following the September 11, 2001 attacks suffer from…
- Conditions
- Cardiac Disease, Cardiopulmonary Disease, Renal Disease, Cardiovascular Disease
- Trial name
- NCT02246101
- Where
- United States
- Volunteers
- 406 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Kidney Disease (CKD), Older Adults (65 Years and Older)
Trazodone and the Risk of Serious Adverse Events
This is a population-based retrospective, new-user, active comparator cohort study assessing whether initiating a new outpatient prescription of trazodone (>75-150 mg/day), compared to a lower dose (25-75 mg/day) is associated…
- Trial name
- NCT07381101
- Testing
- Trazodone HCl
- Where
- Canada
- Volunteers
- 31,459 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Myelodysplastic Syndrome, Acute Myeloid Leukemia
PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias
This is a non-blinded, non-randomized pharmacokinetic study to determine the oral bioavailability of clofarabine, and the effect of cimetidine on clofarabine pharmacokinetics in patients with poor-risk acute leukemias and…
- Conditions
- Myelodysplastic Syndrome, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia
- Trial name
- NCT01169012
- Testing
- Clofarabine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Pituitary Adenoma 1, Acth-Secreting
Pituitary Adenoma and Serum Lipid
Pituitary adenomas are usually benign monoclonal neoplasms caused by a mixture of pituicyte alterations together with a changed endocrine and paracrine regulatory milieu.
- Trial name
- NCT04021212
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shandong Provincial Hospital
Non-ST-elevation Myocardial Infarction
Thrombus Aspiration in ThrOmbus Containing culpRiT Lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI)
Whereas thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI) is recommended by current guidelines, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI).
- Trial name
- NCT01612312
- Testing
- Thrombectomy, Standard percutaneous coronary intervention
- Where
- 7 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University of Leipzig
Hepatocellular Carcinoma, Bilirubinemia
Safety of Transarterial Chemoembolization (TACE) in the Setting of an Elevated Bilirubin
The aim of this study is to evaluate the safety of selective transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) in the setting of an elevated total bilirubin, but relatively normal direct bilirubin.
- Trial name
- NCT03259581
- Testing
- Transarterial chemoembolization
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota
Obesity
PPDTM CorEvitasTM Obesity (OBR) Drug Effectiveness and Safety Registry
The design is an open-ended prospective observational (non-interventional) registry for subjects living with excess weight or obesity under the care of a qualified provider with documented experience treating patients with obesity
- Trial name
- NCT07598981
- Testing
- Biospecimen collection
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- CorEvitas
Public Suicide Stigma
Beneficial and Harmful Effects of Reducing Public Suicide Stigma
There is growing evidence that negative attitudes towards persons affected by suicide (i.e. persons who experience suicidality, persons who lost a loved one to suicide), so called public suicide stigma, is harmful for suicide…
- Trial name
- NCT04756219
- Testing
- Contact Video, Contact Text, Education Video
- Where
- Germany
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Chronic Cholecystitis
Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy
Opioids may attenuate postoperative hyperalgesia and postoperative nausea and vomiting. Our hypothesis is: opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic…
- Trial name
- NCT01833819
- Testing
- Dexmedetomidine and lidocaine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bezmialem Vakif University
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