Clinical trials: Symptom
Fistula in Ano, Ano Fistula
The Impact of 3D Anal Fistula Models on Patient Understanding and Decision Making
An anal fistula is an abnormal communication between the luminal surface of the anorectal canal and the perianal skin. Fistulas can vary in their complexity and can be challenging to treat, due to the anatomical relation to the…
- Trial name
- 3DAF (NCT04069728)
- Testing
- Explanation with 3D printed fistula model, Standard explanation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- London North West Healthcare NHS Trust
Acute Myeloid Leukemia
A Study of Decitabine (DACOGEN) in Sequential Administration With Cytarabine in Children With Relapsed or Refractory Acute Myeloid Leukemia
The purpose of this study is to examine the safety and efficacy of decitabine in sequential administration with cytarabine in children with relapsed or refractory acute myeloid leukemia (AML).
- Trial name
- NCT01853228
- Testing
- Phase1 and Phase 2: decitabine, Phase 1: cytarabine, Phase 2: cytarabine
- Where
- 17 sites in Belgium, Denmark and 5 more
- Volunteers
- 17 people
- Sponsor
- Janssen Research & Development, LLC
Sepsis, Hyperglycemia
Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Often sick children have increased glucose concentrations in blood.
- Conditions
- Sepsis, Hyperglycemia, Critical Illness
- Trial name
- NCT01890928
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Breast Cancer
An Exercise Intervention for Breast Cancer Patients: Feasibility and Effectiveness (BEAT Cancer Trial; Pilot Study)
"Translation" of the current "basic science" information related to physical activity into patient intervention programs is needed. This translation is critical to providing benefit to the maximum number of patients.
- Trial name
- BEAT (NCT00721565)
- Testing
- Exercise Behavior Change
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Alabama at Birmingham
COVID-19, Vaccine
Evaluation of Menstrual Irregularities and Abnormal Uterine Bleeding After Covid-19 Vaccine
Covid-19 vaccines offered a good opportunity to counteract the spread of Sars-Cov-2 infection among the general population, reducing significantly both morbidity and mortality.
- Conditions
- COVID-19, Vaccine, Menstrual Irregularity, Menopausal Bleeding
- Trial name
- MECOVAC-1 (NCT05083065)
- Testing
- Covid-19 vaccine
- Where
- Italy
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Chronic Kidney Disease, Type 2 Diabetes
A Study of RTA 402 in Chronic Kidney Disease (CKD) Patients With Type 2 Diabetes Mellitus
A Phase 2 study of RTA 402 in Chronic kidney disease (CKD) patients with type 2 diabetes mellitus.
- Trial name
- NCT01574365
- Testing
- RTA 402
- Where
- Japan
- Volunteers
- 53 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Asthma, Acute Asthma
Budesonide Inhalation Suspension for Acute Asthma in Children
The purpose of this study is to determine whether the addition of budesonide inhalation suspension (BIS) to the standard therapy of albuterol, ipratropium bromide, and systemic corticosteroids (SCS) for moderate to severe asthma…
- Conditions
- Asthma, Acute Asthma, Reactive Airway Exacerbation
- Trial name
- NCT00393367
- Testing
- Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Children's Hospital of Philadelphia
HPV Positive Oropharyngeal Squamous Cell Carcinoma, Squamous Cell Carcinoma
Combining Neo-adjuvant ATR-inhibition With Nodal SBRT for Early-stage Resectable HPV+ OPSCCs
This research study is testing whether a new study drug (called ATRN-119) is safe and effective when combined with a single, highly targeted dose of radiation therapy (called stereotactic body radiation therapy or SBRT) to treat…
- Conditions
- HPV Positive Oropharyngeal Squamous Cell Carcinoma, Squamous Cell Carcinoma, HPV (Human Papillomavirus)-Associated Carcinoma, HPV Associated Cancers
- Trial name
- NCT07578467
- Testing
- ATRN-119, Stereotactic Body Radiation Therapy (SBRT)
- Volunteers
- 35 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Spinal Cord Injury
Spinal Cord Injury Collaborative Care Study
The objective of this study is to test the effectiveness of a collaborative care approach to improving outpatient treatment for inactivity, chronic pain and depression as a way of improving overall Quality of Life for patients…
- Trial name
- SCI-Care (NCT02026167)
- Testing
- Collaborative Care
- Volunteers
- 174 people
- Sponsor
- University of Washington
Suicide, Depression
Plasma Beta-endorphin Levels and Suicidal Behavior
It is an interventional research, monocentric, which involves only minimal risks and constraints. Psychological pain is closely associated with suicidal ideation (SI) and suicidal behavior, regardless of the severity of the…
- Conditions
- Suicide, Depression, Beta Endorphin
- Trial name
- BEST (NCT06291467)
- Testing
- Blood samples, questionnaires
- Where
- France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Montpellier
Esophageal Cancer, Recurrence
Predicting Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma
The prognosis of patients with esophageal squamous cell carcinoma (ESCC) who develop post-operative early tumor recurrence is often relatively poor.
- Conditions
- Esophageal Cancer, Recurrence, DNA Methylation
- Trial name
- NCT06476067
- Testing
- Surgery
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- City of Hope Medical Center
Chronic Lymphocytic Leukemia
A Prospective Observational Trial to Assess Treatment Sequences and Factors That Impact Overall Sur-vival in Patients With Chronic Lymphocytic Leukaemia (CLL) Treated Within First-line Studies of the GCLLSG
This observational trial is designed to investigate long-term survival with regard to the primary endpoint overall survival (OS) after start of first-line treatment.
- Trial name
- CLL2000 (NCT06792994)
- Testing
- Observational
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German CLL Study Group
Nausea and Vomiting, Postoperative
The Effects of IV vs Oral Dexamethasone on Postoperative Nausea, Vomiting, and Pain
The hypothesis being tested in this study is that perioperative oral administration of dexamethasone, when compared to intravenous (IV) administration, offers a similar reduction in postoperative nausea and vomiting (PONV), and…
- Trial name
- NCT04563494
- Testing
- dexamethasone
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Colorado, Denver
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Atrial Fibrillation
Evaluation of the CIRCA Monitoring System in Prevention of Esophageal Lesions Following RFCA
The purpose of this study is to determine if the use of Circa™ temperature monitoring system during ablation procedures will reduce the risk of esophageal lesions or damage.
- Trial name
- CIRCA-EGD (NCT02467166)
- Testing
- Circa™ Probe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Acute Myocardial Infarction
Cell Therapy in Myocardial Infarction
The purpose of this study is to determine cell therapy efficacy in patients with ST elevation acute myocardial infarction (STEMI)
- Trial name
- EMRTCC (NCT00350766)
- Testing
- Autologous Bone Marrow Mononuclear Cells (ABMMC) Transplantation
- Where
- Brazil
- Volunteers
- 166 people
- Sponsor
- Ministry of Health, Brazil
Quadratus Lumborum Block, Analgesia
Transversus Abdominis Plane Block Plus Quadratus Lumborum Block or Retrolaminar Block of Multiple Injections for Postoperative Analgesia Following Laparoscopic Colorectal Surgery
Our hypothesis was that transversus abdominis plane block plus retrolaminar block would reduce postoperative sufentanil consumption and provide superior analgesia compared with transversus abdominis plane block plus quadratus…
- Conditions
- Quadratus Lumborum Block, Analgesia, Laparoscopic, Colorectal
- Trial name
- NCT05416866
- Testing
- Retrolaminar block on the operative side, Quadratus lumborum block on the operative side, Transversus abdominis plane block on the nonoperative side
- Volunteers
- 100 people
- Sponsor
- dong zhang
ADHD
The Effects of Yoga on Attention, Impulsivity and Hyperactivity in Pre-school Age Children
This pilot project will evaluate yoga as an intervention to improve attention and reduce challenging behaviors such as hyperactivity and impulsivity, rated by parent and teachers, in preschool age children with or "at risk" for…
- Trial name
- NCT02642666
- Testing
- Children's Yoga
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Novel Oral Anticoagulants, NOACs
Imapct of bioMarkers on Pharmacodynamics and Bleeding Risk of Direct Oral AntiCoagulants and Ticagrelor Study II
Individual differences in drug efficacy and adverse reactions are common in the clinical application of drugs. Individual differences are caused by many factors, among which genetic factors account for more than 20%.
- Conditions
- Novel Oral Anticoagulants, NOACs, Rivaroxaban, Apixaban
- Trial name
- NCT05764356
- Testing
- Detection of genotype and RNA profile in platelet and white blood cell, Indicators test related to coagulation function, Indicators test related to platelet function
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Peking University First Hospital
Analgesia
Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following HTO/DFO/TTO
A randomized, single-blind, single-center study measuring the effects of adductor canal block combined with IPACK infiltration compared to adductor canal block alone on post-operative pain and opioid consumption in patients…
- Trial name
- NCT06952556
- Testing
- ACB, IPACK block
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.