Clinical trials: Symptom
Arthritis, Rheumatoid
Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis
The purpose of this study is to determine whether milnacipran reduces widespread, non-joint pain in patients with rheumatoid arthritis (RA).
- Trial name
- NCT01207453
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Brigham and Women's Hospital
Obesity
Support and Tracking to Achieve Results (Project STAR)
The investigators propose to conduct a randomized controlled trial assessing the impact of phone-based extended care delivered on an ADAPTIVE (when participants are at "high risk" for weight regain as assessed by a predictive…
- Trial name
- NCT04116853
- Testing
- ADAPTIVE Extended-Care Program, STATIC Extended-Care Program
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of Florida
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Diaphragmatic Pacer Placement: Anesthetic Management (DP)
The diaphragmatic pacemaker (DP) has proven its utility in replacing mechanical ventilation (MV) in patients with chronic spinal cord injury (SCI) and Amyotrophic Lateral Sclerosis (ALS), by improving the patients quality of life…
- Conditions
- Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Respiratory Paralysis
- Trial name
- DP (NCT02942953)
- Testing
- Diaphragmatic Pacer
- Volunteers
- 16 people
- Sponsor
- Institut Guttmann
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
Chronic Obstructive Pulmonary Disease
Study to Evaluate the Safety and Efficacy of Formoterol in a Daily Dose of 18 µg (9 µg Twice Daily) in Japanese Chronic Obstructive Pulmonary Disease (COPD) Patients
This study is a multicentre, open, randomised, parallel-group study with formoterol 9 μg one inhalation b.i.d, or standard COPD therapy.
- Trial name
- NCT01047553
- Testing
- Formoterol (OT)
- Where
- 27 sites in Japan
- Volunteers
- 251 people
- Sponsor
- AstraZeneca
Pain, Hemodynamic Instability
The Effect of Virtual Reality Glasses on Pain Level and Hemo-Dynamic Variables After Open Heart Surgery
In this study, between 1 January 2025 - 1 June 2025, who met the inclusion and exclusion criteria, a total of 82 patients who are on the 2nd or 3rd day after the surgery and who are hospitalized in the cardiovascular surgery…
- Trial name
- Virtual (NCT05585853)
- Testing
- virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Mersin University
Chronic Obstructive Pulmonary Disease (COPD)
REGEND001 Autologous Basal Layer Stem Cell Transplantation for Chronic Obstructive Pulmonary Disease (COPD): A Translational Application Study
This clinical trial aims to evaluate the safety and efficacy of REGEND001, an autologous bronchial basal cell therapy, for the treatment of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT06946953
- Testing
- P63+ lung progenitors
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Pain
Duration of Skin Numbing Effect Created by the S-Caine™ Peel
S-Caine™ Peel (lidocaine 7% and tetracaine 7% cream) is a new skin numbing cream made of lidocaine and tetracaine. The purpose of this study is to evaluate and measure the length of time the S-Caine Peel numbs the skin, when…
- Trial name
- NCT00110253
- Testing
- S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ZARS Pharma Inc.
Pancreatic Cancer Pain
EUS Guided Celiac Neurolysis
Hypothesis: Direct CGN enhances neurolytic drug delivery into celiac ganglia and increases the efficacy of neurolysis and subsequent pain control and survival in patients with pancreatic carcinoma.
- Trial name
- NCT01615653
- Testing
- EUS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Depression
Exploring the Suitability of Movement and Sound in Couple Therapy: A Proof-of-Concept Trial
The present phase-IIA waiting-list controlled proof-of-concept trial aims to explore the adequacy of immediate sound feedback for physical distance and touch between individuals as a potential means to complement existing methods…
- Trial name
- NCT04830553
- Testing
- Music-based couple therapy.
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive
An Observational Biomarker Study in Multiple Sclerosis (MS) Patients
All males and females between 18-70 years of age regardless of their race and ethnicity with a confirmed diagnosis of Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS), and Relapse…
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT05663853
- Where
- 4 sites in United States
- Volunteers
- 137 people
- Sponsor
- LAPIX Therapeutics Inc.
Inflammation, Skin Inflammation
Skin Barrier Function and Inflammation in Aging: The BIA Study
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin.
- Conditions
- Inflammation, Skin Inflammation, Aging
- Trial name
- BIA (NCT06750653)
- Testing
- CeraVe Moisturizing Cream, Vaseline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain, Acute, Edema
Lornoxicam Versus Etodolac After Third Molar Surgery
Our study aimed to compare the effect of lornoxicam and etodolac on postoperative pain, edema and trismus following lower third molar extraction
- Conditions
- Pain, Acute, Edema, Trismus
- Trial name
- NCT05679453
- Testing
- Lornoxicam 8 Mg Oral Tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Heparin-Induced Thrombocytopenia
Heparin-Induced Thrombocytopenia Score Card Study
Main Research Question: Can two new types of test, one called the 4T's score and the other called a rapid assay, help doctors correctly identify which patients are unlikely to have heparin-induced thrombocytopenia (HIT)? HIT is a…
- Trial name
- NCT00489437
- Testing
- ID-PaGIA Heparin/PF4 antibody test, Clinical Prediction Score-HIT Score Card
- Where
- Canada
- Volunteers
- 536 people
- Sponsor
- McMaster University
Pulpitis - Irreversible, Vitamin D Deficiency
Effect of Vitamin D on Postoperative Pain in Symptomatic Irreversible Pulpitis
Vitamin D deficiency (VDD) is a prevalent global health concern that has been linked to altered pain perception through its effects on inflammatory pathways, nociceptor activity, and neurotrophic signaling.
- Trial name
- NCT07579637
- Testing
- Vitamin D3
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Future University in Egypt
Anal Fistula, Rectal Fistula
Surgical Treatment of High Perianal Fistulas
Perianal fistula is a chronic phase of anorectal infection that occurs predominantly in the third and fourth decade of life. According to Parks classification fistulas have been divided into intersphincteric, transsphincteric…
- Trial name
- LIFTRAF (NCT01997645)
- Testing
- LIFT, RAF
- Where
- 3 sites in Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Hradec Kralove
Amblyopia
Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT05522972
- Testing
- Video Game Vision Training, Perceptual Learning, Occlusion Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Infectious Disease, Therapeutics
Rickettsia Clearance Study
Murine typhus is a disease caused by Rickettisa typhi, an obligate intracellular bacterium transmitted by rodent fleas. The disease has a worldwide distribution; however the true burden is unknown, related to its non-specific…
- Trial name
- RiCS (NCT05972772)
- Testing
- Doxycyclin, Azithromycin
- Where
- 2 sites in Laos
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
Sleep Disorders
Clinical Trial on a Food Supplement With Melatonin and Herbal Products to Improve Sleep Quality
A randomized, double-blind, placebo-controlled clinical trial on the ability of a dietary supplement containing melatonin and herbal products to improve sleep quality in subjects with insomnia problems with a 15-day follow-up…
- Trial name
- NCT05459272
- Testing
- Aquilea Sueno Forte
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Uriach Consumer Healthcare
Critical Illness
Modified Pediatric Early Warning Score and Modified PRISA II During COVID-19 Pandemic
One of the most important factors in pediatric emergency units is the correct decision of the patient inpatient or outpatient treatment. If the disease progresses critically, the decision of hospitalization comes to the fore.
- Trial name
- NCT04876872
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 894 people
- Sponsor
- Karadeniz Technical University
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