Clinical trials: Symptom
Myocardial Infarction
Cardiovascular Medication Use Before First Myocardial Infarction
Large randomised trials have shown that cardiovascular medications prescribed to patients at high cardiovascular risk are effective in reducing the incidence of cardiovascular events.
- Trial name
- NCT01692795
- Where
- United Kingdom
- Volunteers
- 17,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Cardiovascular Surgery, Pain, Postoperative
Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery
The purpose of this study is to find out what effects (good and bad) that the study medicine called "liposomal bupivacaine" has on subjects that are undergoing a sternotomy.
- Conditions
- Cardiovascular Surgery, Pain, Postoperative, Block
- Trial name
- NCT04333095
- Testing
- Liposomal bupivacaine, Normal Saline Flush, 0.9% Injectable Solution_#1
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Baylor Research Institute
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara
Instability, Joint, Shoulder Dislocation
Improvement of Fatigue in Unstable Shoulder Through a Therapeutic Exercise Program in Physiotherapy
Background: Glenohumeral instability is a highly prevalent pathology; however, there is great controversy in its definition. Traditionally, structural problems such as labral injury or bone loss in the glenoid cavity were…
- Conditions
- Instability, Joint, Shoulder Dislocation, Fatigue, Therapeutic Alliance
- Trial name
- NCT05443295
- Testing
- MoveUS Program, Control intervention
- Where
- 2 sites in Spain
- Volunteers
- 108 people
- Sponsor
- University of Malaga
Sepsis
Sepsis-Associated Purpura Fulminans International Registry - Europe
Sepsis-associated Purpura fulminans (SAPF) is a rare life-threatening condition. It is characterized by multiple skin lesions which rapidly progress to necrosis and gangrene.
- Trial name
- SAPFIRE (NCT02238795)
- Where
- 3 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Jena University Hospital
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Acute Brain Injury, Traumatic Brain Injury
Implementation of Neuro Lung Protective Ventilation
Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke
- Trial name
- NEUROVENT (NCT03243539)
- Testing
- Lung Protective Ventilation
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Colin Grissom
Nutrition, Constipation
Nutrition and Constipation at Inguinal Hernia Patients
There are lots of inguinal hernia risk factors determined in the literature. But the relationship between nutritional status and inguinal hernia were not examined yet.
- Conditions
- Nutrition, Constipation, Inguinal Hernia
- Trial name
- NCT03937739
- Testing
- Nutritional and constipation questionnaire
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 203 people
- Sponsor
- Istanbul University
Obesity, NAFLD
Study of NGM395 in Adult Participants
Study of NGM395 in adult participants.
- Trial name
- NCT04187339
- Testing
- NGM395
- Where
- Australia
- Volunteers
- 38 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Obesity
Effects of OAGB and DJB-SG on 10-year and Lifetime Risks of MACE
Metabolic bariatric surgery (MBS) has demonstrated its efficacy in achieving sustainable weight loss and alleviating associated comorbidities.
- Trial name
- NCT06254339
- Testing
- OAGB, DJB-SG
- Volunteers
- 830 people
- Sponsor
- National Defense Medical Center, Taiwan
Surgical Wound Infection, Neck Infection
Antibiotic Tissue Penetration and Tissue Response in Head and Neck Infection and Reconstructive Surgery
The goal of this study is to measure how well commonly used antibiotics reach the tissue in the head and neck region in adults with a postoperative neck infection or undergoing reconstructive nasal surgery with an inferior…
- Conditions
- Surgical Wound Infection, Neck Infection, Nasal Reconstruction
- Trial name
- ANTIBIOTIKA (NCT07896239)
- Testing
- Cefuroxime, Dicloxacillin, Cloxacillin
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Tejs Ehlers Klug
Healthy, Head and Neck Cancer
Rehabilitation Assessment and Progress Tracking System Based on Video Images for Dysphagic Patients
The current cervical range of motion (CROM) and tongue movement measurement methods are not reliable between observers, which is not practical in real-world usage.
- Trial name
- NCT05141539
- Testing
- Rehabilitation assessment software, VFSS and FOIS
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Dyslipidemia, Obesity
Chronic Effects of Freeze-Dried Strawberry Beverage on Cardiovascular Risk Factors
Berry anthocyanins have been shown to improve lipid profile in subjects with dyslipidemia while no such studies with whole strawberries have been reported in the US population.
- Trial name
- NCT01883401
- Testing
- Freeze-dried strawberries, Dietary fiber
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oklahoma State University
Post-operative Pain, Quadriceps Muscle Strength
Ultrasound Guided Adductor Canal Versus Femoral Nerve Blocks for Anterior Cruciate Ligament Reconstruction in Pediatrics
Both Ultrasound guided Adductor Canal Block ( ACB) and Femoral Nerve Block (FNB) has been used to provide postoperative analgesia for knee surgeries.
- Trial name
- NCT03053401
- Testing
- Adductor Canal Block, Femoral Nerve Block, Ultrasound
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Akron Children's Hospital
Chronic Disease, Mental Illness
Tablet-Enabled Video Telehealth to Enhance Veterans' Access and Care
In order to enhance access to clinical and mental health services for Veterans who have geographic, clinical, or social barriers to in-person care, VA Offices of Connected Care and Rural Health began distributing 5,000 tablets to…
- Trial name
- NCT03089801
- Testing
- Tablet-Enabled Video Telehealth
- Where
- United States
- Volunteers
- 32,186 people
- Sponsor
- VA Palo Alto Health Care System
Infant Botulism, Botulism
Study of Human Botulism Immunoglobulin in Infants With Botulism
OBJECTIVES: I. Determine the safety of human botulism immune globulin (BIG) in patients with infant botulism by monitoring side effects (e.g., rash, fever, hypotension, and anaphylaxis). II.
- Trial name
- NCT00004401
- Testing
- botulism immune globulin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- California Department of Health Services
Relapsed Cancer, Refractory Multiple Myeloma
Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma
The main goal of this phase II study is to evaluate the overall response rate of isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone in relapsed and refractory multiple myeloma.
- Conditions
- Relapsed Cancer, Refractory Multiple Myeloma, Multiple Myeloma
- Trial name
- ISABELA (NCT05922501)
- Testing
- Isatuximab, Belantamab mafodotin, Pomalidomide
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Neuromuscular Diseases, Respiration, Artificial
Quality of Life in Ventilator-dependant Neuromuscular Patients
This study aims at evaluating the quality of life of patients with slowly progressive neuromuscular disorders who are dependant on mechanical ventilation (daily usage ≥ 16h).
- Conditions
- Neuromuscular Diseases, Respiration, Artificial, Tracheostomy, Noninvasive Ventilation
- Trial name
- EqualVENT (NCT04652401)
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Physical Functioning, Musculoskeletal Pain
Personalized Exercise Counseling to Promote Workability
The study design is a 2-arm randomized controlled trial with 6-month intervention period and follow-up at 6, 12 and 24 months among blue-color workers of Nokia City with reduced work ability and high number of musculoskeletal…
- Conditions
- Physical Functioning, Musculoskeletal Pain, Quality of Life, Physical Activity
- Trial name
- PEC-Nokia (NCT03854201)
- Testing
- Personalized Exercise Counseling (PEC)
- Where
- Finland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- UKK Institute
Chronic Lymphocytic Leukemia
Ofatumumab Added to Dexamethasone in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia
The rationale of the study is to explore the safety and efficacy of ofatumumab in combination with dexamethasone (O-dex regimen) in patients with refractory/relapsed CLL.
- Trial name
- NCT01310101
- Testing
- ofatumumab plus dexamethasone
- Where
- 4 sites in Czechia
- Volunteers
- 33 people
- Sponsor
- Brno University Hospital
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