Clinical trials: Symptom
Coronary Artery Bypass, Myocardial Infarction
The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)
The purpose of this study is to determine whether acadesine is effective in reducing the cardiovascular and cerebrovascular adverse events in high-risk participants undergoing CABG surgery.
- Conditions
- Coronary Artery Bypass, Myocardial Infarction, Ventricular Dysfunction, Left, Stroke
- Trial name
- RED-CABG (NCT00872001)
- Testing
- Acadesine, Normal Saline
- Volunteers
- 3,080 people
- Sponsor
- Merck Sharp & Dohme LLC
Post Operative Pain
Does the Application of a Bilateral-dual Transverse Abdominal Plane (TAP)Block Have an Influence on Lung Function?
TAP-block (Transverse Abdominal Plane) block is a method of regional anesthesia used after abdominal surgery. The method is often applied ultra-sound guided.
- Trial name
- NCT01254812
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Pain, Postoperative; Anesthesia, Regional
Analgesic Efficacy of Ultrasound Guided Paravertebral Block in Percutaneous Nephrolithotomy Patients
The aim of this study is to investigate the analgesic effects of thoracal paravertebral block in the patients undergoing percutaneous nephrolitotomy. Paravertebral block was applied to the study group.
- Trial name
- NCT04406012
- Testing
- paravertebral block
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Pulmonary Embolism, Covid-19
Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms
Multicentric case-control study that is aims at: evaluating the prevalence of pulmonary embolism among a large population of consecutive patients admitted for COVID-19 pneumonia into two large university hospitals in Paris…
- Trial name
- COVID-EP (NCT04420312)
- Where
- France
- Volunteers
- 1,024 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Pain, Chronic, Sleep
Sleep, Pain and Stress in Adolescents With Persistent Pain
The main aim is the gain information of sleep structures in adolescents with persistent pain. Also to study simple interventions to support their sleep and pain management.
- Trial name
- PedPainSleep (NCT05677412)
- Testing
- suggestive relaxation, Neutral story
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
Pain
Effectiveness of Analgesia in Total Knee Arthroplasty
The purpose of this study is to compare the analgesic effectiveness of three techniques: the femoral nerve block, intraarticular infiltration or a combination of both in the control of pain in total knee arthroplasty (KA).
- Trial name
- ATR-2011 (NCT01304212)
- Testing
- several drugs: morphine chloride,ropivacaine,epinephrine,ketorolac, ropivacaine,morphine chloride,epinephrine,ketorolac, ropivacaine
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Jose Antonio Bernia Gil
Asthma
The Development of a Clinical Test to Assess the Inflammatory Phenotype of Asthma
The purpose of this study is to determine the type and degree of inflammatory parameters in peripheral blood of asthma patients compared to analysis of induced sputum.
- Trial name
- AIR (NCT01611012)
- Where
- Netherlands
- Volunteers
- 115 people
- Sponsor
- Prof. Jan-Willem Lammers MD PhD
Immune Thrombocytopenia
A Multicentre Investigation of 2 Cycles Rituximab Compared With Standard Regimen in Management of Steroid-Resistant/Relapsed Immune Thrombocytopenia （ITP）
The project was undertaking by Qilu Hospital, Shandong University and other several well-known hospitals in China. In order to report the efficacy and safety of Rituximab in different frequencies for the treatment of adults with…
- Trial name
- NCT02137681
- Testing
- Rituximab
- Where
- China
- Sponsor
- Shandong University
Urinary Incontinence
Clinical Study of External Electrical Stimulation for Male Incontinence
The purpose of this research is to evaluate the effectiveness of the Elidah neuromuscular stimulation treatment to reduce incontinence in men post-prostatectomy.
- Trial name
- NCT06620419
- Testing
- Perineal-applied electrical stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Elidah, Inc.
Tuberculosis, Pulmonary, Tuberculosis, MDR
Adjunctive Acetylsalicylic Acid and Ibuprofen for Tuberculosis
The purpose of this study is to assess the efficacy and safety of 2 repurposed drugs (acetylsalicylic acid and ibuprofen), for use as adjunct therapy added to, and compared with, the standard of care (SoC) WHO-recommended TB…
- Conditions
- Tuberculosis, Pulmonary, Tuberculosis, MDR, Tuberculosis Infection
- Trial name
- SMA-TB (NCT04575519)
- Testing
- Control group, ASA group, IBU group
- Where
- 3 sites in Georgia, South Africa
- Volunteers
- 426 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Intracranial Hemorrhages
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
The overall goal is to establish the safety and efficacy of colchicine in ICH patients for the prevention of major cardiovascular events and brain injury.
- Trial name
- CoVasc-ICH (NCT05159219)
- Testing
- Colchicine Pill
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Bipolar Depression
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression
This study is an open-label, single-arm, proof-of-concept study, wherein treatment resistant bipolar depression (TRBD) participants will receive one 25 mg dose of oral psilocybin accompanied by preparatory, monitoring, and…
- Trial name
- Psilo-BD (NCT06506019)
- Testing
- Psilocybin, Functional MRI
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Metastatic Cancer
Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion
RATIONALE: Morphine and ibuprofen help lessen pain caused by pleurodesis. It is not yet known whether one drug is more effective than the other in lessening pleurodesis-related pain or whether the size of the chest drain tube…
- Trial name
- NCT00644319
- Testing
- ibuprofen, morphine sulfate, management of therapy complications
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- Oxford University Hospitals NHS Trust
Postoperative Nausea and Vomiting, Dexamethasone Palmitate
Dexamethasone Palmitate for PONV After Open Surgery
Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone…
- Conditions
- Postoperative Nausea and Vomiting, Dexamethasone Palmitate, Open Surgery
- Trial name
- NCT06997419
- Testing
- Dexamethasone Palmitate, Dexamethasone
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Critical Illness, Physical Disability
Neuromuscular Electrical Stimulation (NMES) Preserves Muscle Mass in Intensive Care Unit (ICU)
Background: Low-frequency neuromuscular electrical stimulation (NMES) attenuates the loss of muscle mass of Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Physical Disability, Muscle Atrophy
- Trial name
- NCT05287919
- Testing
- Patients received the standard physical therapy (SPT) programme (passive mobilization) twice a day., Patients received the low-frequency neuromuscular electrical stimulation (NMES), Patients received the medium-frequency neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 54 people
- Sponsor
- Gabriel Nasri Marzuca-Nassr
Parkinson's Disease, Parkinsonian Disorders
Gait Analysis in Neurological Disease
The purpose of this study is to investigate whether speed-dependent measures of gait (so called gait signatures) can be identified in patients with neurological conditions that affect gait, particularly in subjects with…
- Conditions
- Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy
- Trial name
- NCT02994719
- Testing
- Anti-Parkinson medication, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity and Overweight
The Efficacy and Safety of Efsubaglutide Alfa in Overweight/Obesity（SPARKLE）
This is a multicenter, double-blind, randomized, placebo-controlled phase Ⅱ study to evaluate the efficacy, safety, pharmacokinetics, and immunogenicity of YN-011 in subjects with overweight (27 kg/m2 ≤ BMI < 30 kg/m2, with at…
- Trial name
- NCT07114419
- Testing
- Efsubaglutide Alfa 20 mg QW, Efsubaglutide Alfa 40 mg QW, Efsubaglutide Alfa 40 mg Q2W
- Where
- 5 sites in Australia
- Volunteers
- 200 people
- Sponsor
- Shanghai Yinnuo Pharmaceutical Technology Co., Ltd.
Alzheimer Disease 10, Dementia
Cognitive Stimulation Therapy
The concept of cognitive stimulation in AD is one of the most popular approaches. Cognitive Stimulation Therapy (CST) is stated to be evidence-based best practice with robust clinical trials, administered according to specific…
- Conditions
- Alzheimer Disease 10, Dementia, Apathy, Anxiety
- Trial name
- NCT05808530
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Hasan Kalyoncu University
Asthma
A Case-control Study on the Differentiation Between Cough Variant Asthma and Chronic Cough
this study aimed to compare characters in pulmonary function of patients with cough variant asthma and chronic cough and establish a diagnostic model.
- Trial name
- NCT06199830
- Testing
- positive bronchial provocation test
- Where
- China
- Volunteers
- 645 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Interventions Pain
The Effects on Pain of Acupressure and Foot Reflexology Before Heel Lancing in Newborns
This study aimed to determine the effects of foot reflexology and acupressure on the KI3 and St36 points on pain during interventions when these procedures were administered before heel lancing in term newborns.
- Trial name
- NCT04643730
- Testing
- Acupressure methods, Foot Reflexology Methods, Control Grup
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
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