Clinical trials: Symptom
Pain, Postoperative
Pain After Tonsillectomy Study
Pain is a common experience in childhood. Healthy children can undergo up to 20 painful procedures by the age of 5. Moreover, millions of children undergo surgery (e.g., tonsillectomies) each year, which is commonly linked to…
- Trial name
- PAT (NCT03538730)
- Testing
- Memory Reframing
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Postpartum
Effects of Manual Lymph Drainage on Breast Engorgement in Postpartum Period.
There have been many studies on the treatment of breast engorgement, there is a lack of research comparing the effectiveness of manual lymph drainage with massage.
- Trial name
- NCT06168630
- Testing
- Manual lymph drainage, Control group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Corneal Neovascularization
Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization
OBJECTIVES: I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser photodynamic therapy (PDT) in patients with corneal neovascularization. II.
- Trial name
- NCT00004430
- Testing
- Dihematoporphyrin derivative, prednisolone, Laser surgery
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical College of Hampton Roads
Pain, Depression
Stepped Care for Depression and Musculoskeletal Pain
This study will evaluate the effectiveness of a stepped care approach in treating depression and reducing pain.
- Trial name
- NCT00118430
- Testing
- Stepped Care, Antidepressants, Usual Care
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Indiana University
Muscle Atrophy, Surgery
Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
The loss of muscle mass post-surgery confounds recovery efforts and leads to a delay in patient's ability to return to activities.
- Conditions
- Muscle Atrophy, Surgery, Knee Injuries and Disorders, Complication of Surgical Procedure
- Trial name
- NCT04456530
- Testing
- Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Stone Research Foundation for Sports Medicine and Arthritis
Organ Transplantation From Brain-dead Donors
Cooling to Optimize Organ Life in Donor Study
The purpose of this study is to assess the feasibility and safety of mild-to-moderate hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60 brain-dead organ donors.
- Trial name
- COOLDonor (NCT01544530)
- Testing
- Cold isotonic fluid and central venous hypothermia catheter
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pittsburgh
Shock, Septic, Renal Failure, Acute
Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care)
Sepsis and septic shock are still important causes of mortality in intensive care medicine. Renal replacement therapy by standard volume haemofiltration is currently used, but a higher-volume haemofiltration may improve the…
- Trial name
- IVOIRE (NCT00241228)
- Testing
- Venovenous haemofiltration (renal replacement therapy)
- Where
- 16 sites in Belgium, France and 1 more
- Volunteers
- 139 people
- Sponsor
- University Hospital, Bordeaux
Post Treatment Lyme Syndrome (PTLS), Chronic Pain
Uncovering Neural and Immune Mechanisms of Chronic Pain in Post Treatment Lyme Syndrome
This study will investigate (a) neural and immune mechanisms underlying chronic pain in PTLS by comparing a group of PTLS patients and healthy participants on brain imaging, sensory, and immune markers; and (b) assess change in…
- Trial name
- PTLS (NCT02687165)
- Testing
- Milnacipran and D-cycloserine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Obesity, Morbid Obesity
Ultrasound-Guided Axillary Brachial Plexus Block: Influence of Obesity
Axillary brachial plexus block (freezing the nerves in armpit) is commonly performed as a primary anesthetic technique for the elbow/ forearm or hand surgery.
- Trial name
- NCT02033265
- Testing
- Brachial plexus block
- Where
- Canada
- Volunteers
- 249 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Fibromyalgia, Chronic Pain
Tai Chi Intervention and Brain Imaging Study Among Fibromyalgia Patients and Healthy Controls
This exploratory study proposal is the first pilot brain imaging study to determine if Tai Chi can modulate brain resting state functional connectivity (rsFC) and brain morphometry among fibromyalgia (FM) patients and healthy…
- Trial name
- fMRI/FMEX (NCT02407665)
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
COPD, Frailty
The Effect of Frailty on Balance, Activities of Daily, and Exercise Capacity in COPD
The investigators aim to demonstrate whether balance, cognition and activities of daily living have changed in COPD patients with and without frailty.
- Trial name
- NCT03840941
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Hacettepe University
Stroke
Extern Validation of a Predictive Score of Brain Death in Severe Stroke (DIAPASON1)
There is currently a shortage of organ in France, for patients with chronic diseases who are on the waiting list for an organ. The first source of organ donor in France is patients with brain death.
- Trial name
- DIAPASON1 (NCT03612141)
- Where
- 25 sites in France
- Volunteers
- 650 people
- Sponsor
- Central Hospital, Nancy, France
Iron Deficiency Anaemia
Time to Relapse of Iron Deficiency Anaemia After Standard Treatment With The Intravenous Iron (Monofer®)
The objective is to monitor and quality assure the efficacy, including effects on quality of life, and safety of Monofer® in Chronic Kidney Disease and Inflammatory Bowel Disease patient populations when Monofer® is used…
- Trial name
- NCT02546154
- Testing
- 10% Iron Isomaltoside 1000
- Where
- United Kingdom
- Volunteers
- 359 people
- Sponsor
- Pharmacosmos UK Ltd
Somatosensory Tinnitus, Subjektif tınnitus
COMPARISON OF MANUAL THERAPY, TINNITUS RETRAINING THERAPY
This randomized controlled trial aims to compare the effectiveness of Manual Therapy (MT), Tinnitus Retraining Therapy (TRT), and their combination in adults with somatosensory tinnitus.
- Trial name
- TINNITUS (NCT07740954)
- Testing
- Manuel therapy
- Volunteers
- 65 people
- Sponsor
- Suleyman Demirel University
Veterans, Obesity
An M-Health Intervention in Rural Veterans
MapTrek is a mobile-phone-based web app that allows participants to take a virtual walk in interesting locations around the world while tracking their progress against the progress of other veterans on an interactive map.
- Conditions
- Veterans, Obesity, Overweight
- Trial name
- NCT03720054
- Testing
- MapTrek, Fitbit
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of Iowa
Chronic Kidney Disease
Correlation of Urinary Kallikrein With Cytokines, Proteinuria and Renal Function in Chronic Renal Disease Patients
Urinary kallikrein excretion is known to increase in patients with nephrotic syndrome and sick cell disease, but decrease in patients with chronic kidney disease or uremia.
- Trial name
- NCT00395005
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia
Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorders
This phase I trial is studying the side effects and best dose of vorinostat when given together with cytarabine and etoposide in treating patients with relapsed or refractory acute leukemia or myelodysplastic syndromes or…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7)
- Trial name
- NCT00357305
- Testing
- vorinostat, cytarabine, etoposide
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Eating Disorders, Female Athlete Triad
Efficacy of the Female Athlete Body Project (FAB)
Given the cost of treating eating disorders and the substantial morbidity and mortality associated with these disorders, prevention of eating disorders has considerable public health significance.
- Trial name
- FAB (NCT01735994)
- Testing
- Healthy Weight, Brochure
- Where
- United States
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Coronary Artery Disease
Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents
Prospective, multicenter, registry of at least 11,000 (and up to 15,000) consecutive patients with coronary artery disease undergoing stent-assisted percutaneous coronary intervention (PCI) using DES without major procedural…
- Trial name
- ADAPT-DES (NCT00638794)
- Testing
- Drug -Eluting Stent (Taxus™, Cypher®, Endeavor™, Xience V™)
- Where
- 8 sites in United States
- Volunteers
- 8,575 people
- Sponsor
- Cardiovascular Research Foundation, New York
Bipolar Disorder
Adjunctive Isradipine for the Treatment of Bipolar Depression
This study investigates the medication isradipine, which is currently approved by the FDA to treat high blood pressure, in the treatment of depression in bipolar disorder.
- Trial name
- Isradipine (NCT01784666)
- Testing
- Isradipine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
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