Clinical trials: Symptom
Neoplasm Metastasis
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
This is a global, multicenter, open-label safety extension study. Participants receiving single-agent trastuzumab emtansine or trastuzumab emtansine administered in combination with other anti-cancer therapies in a Genentech /…
- Trial name
- NCT00781612
- Testing
- Docetaxel, Paclitaxel, Pertuzumab
- Where
- 179 sites in United States, Australia and 33 more
- Volunteers
- 378 people
- Sponsor
- Genentech, Inc.
Health Care Utilization, Depression
Health and Health Care Utilization Effects of Medical Debt Forgiveness
The goal of this study is to estimate the direct, causal impact of medical debt on health care utilization, mental health, and wellbeing of patients.
- Conditions
- Health Care Utilization, Depression, Anxiety, Subjective Wellbeing
- Trial name
- NCT04835012
- Testing
- Medical debt forgiveness
- Where
- United States
- Volunteers
- 15,008 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Substance Use Disorders, Hiv
HIV, Equity, and Addiction Training (HEAT) Program
This project is a pilot study to determine the feasibility and acceptability of a telemedicine intervention for substance use disorder service delivery in diverse people living with HIV in Alabama.
- Conditions
- Substance Use Disorders, Hiv, Opioid Use Disorder, Stimulant Use (Diagnosis)
- Trial name
- HEAT (NCT06370481)
- Testing
- Telemedicine, Standard of care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Post-operative Pain
Buprenorphine Sublingual Spray for the Treatment of Moderate to Severe Pain
This is a phase 3, multicenter, randomized, double-blind, multiple-dose, parallel-group, placebo-controlled study to evaluate the safety and efficacy of up to 3 dosing regimens of Buprenorphine Sublingual (under the tongue) Spray…
- Trial name
- NCT02310581
- Testing
- Buprenorphine Sublingual Spray
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- INSYS Therapeutics Inc
Low Back Pain
Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain
The primary objective of this study is to document and compare diagnostic test results and procedure safety in subjects undergoing both Functional Anaesthetic DiscographyTM (F.A.D.) and provocative discography (PD) and determine…
- Trial name
- SODA (NCT00443781)
- Testing
- functional anesthetic discography, provocative discography
- Where
- 10 sites in United States
- Volunteers
- 62 people
- Sponsor
- Medtronic Spine LLC
Liver Fibrosis
Optimized Treatment and Regression of HBV-induced Liver Fibrosis
Patients with chronic hepatitis B histologically confirmed of liver fibrosis S2/S3 (similar to metavir F2/F3, Ishak 2/3/4) are randomly assigned in a 1:1 ratio.
- Trial name
- NCT01938781
- Testing
- entecavir, Peg-IFN
- Where
- 21 sites in China
- Volunteers
- 400 people
- Sponsor
- Beijing Friendship Hospital
Postoperative Pain, Asymptomatic Apical Periodontitis
Effect of Rotary File Number on MB2 Canal Negotiation and Postoperative Pain
This randomized controlled clinical trial aims to evaluate the effect of the number of rotary files on working length negotiation and postoperative pain in the second mesiobuccal (MB2) canals of maxillary first molars.
- Trial name
- MB2-PAIN (NCT07091981)
- Testing
- One Curve Rotary File, Perfect Super System Minimal Invasive Kit, VDW Rotate
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Mehmet Adıgüzel
Brain and Central Nervous System Tumors, Breast Cancer
Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00019019
- Testing
- carboxyamidotriazole, paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Postpartum Hemorrhage
Tranexamic Acid and Ethamsylate For Preventing PPH in Patient Undergoing LSCS at High Risk For PPH
The aim of this study is to compare the effect of low dose of Tranexamic acid (1gm) and Ethamsylate (1gm) after prophylactic oxytocin administration versus placebo with prophylactic oxytocin given in the 2 minutes after child…
- Trial name
- NCT02604719
- Testing
- Tranexamic Acid and Ethamsylate
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ahmed Alanwar
Obesity, Inflammation
Combining HIIT and n-3 PUFA to Reduce Inflammation and Improve Metabolic Health
The goal of this project is to understand the combined effects of fish oil and exercise in obesity-associated inflammation. The investigators hypothesize that fish oil will improve gut bacteria profiles, which will in turn…
- Conditions
- Obesity, Inflammation, Human Microbiome, Insulin Resistance
- Trial name
- HIIT&PUFA (NCT05295719)
- Testing
- Omega-3 polyunsaturated fatty acid, High-Intensity Interval Training, Safflower oil
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Texas Tech University
Heart Failure, High Blood Pressure
BVA-200 vs BVA-100 Validation Study
The proposed study is a prospective, observational, investigator and patient blinded study comparing the results of blood volume measurement using the FDA-cleared Daxor BVA-100 device to the Daxor BVA-200 device.
- Conditions
- Heart Failure, High Blood Pressure, High Cholesterol, Anemia
- Trial name
- NCT06227819
- Testing
- BVA-200
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Daxor Corporation
Chronic Spinal Pain
Protocol for a Randomized Controlled Trial Comparing the Effectiveness of Mechanical Diagnosis and Therapy Versus Generalized Exercise for Reducing Pain in Surgeons With Chronic Spinal Pain
Surgeons frequently experience chronic spinal pain due to prolonged static postures and repetitive movements during surgical procedures.
- Trial name
- NCT07293130
- Testing
- Mechanical Diagnosis and Therapy (MDT), Generalized Exercise
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Claus Kjærgaard
Sepsis
Multi-marker INDex for the Risk Assessment of Sepsis in the Emergency departmenT (MINDSET)
The purpose of the study is to procure blood samples from patients ≥18 years of age who present to the Emergency Department (ED) with at least two of the diagnostic criteria for sepsis.
- Trial name
- MINDSET (NCT00472628)
- Testing
- Blood samples collected
- Where
- 24 sites in United States
- Sponsor
- Abbott RDx Cardiometabolic
Parenting, Parent-Child Relations
Parenting Young Children in Pediatrics
In this study, investigators will partner with pediatric primary care providers to recruit parent participants, then evaluate feasibility and acceptability by systematically assessing parents' engagement with the FCU Online app.
- Conditions
- Parenting, Parent-Child Relations, Substance Use Disorders, Stress
- Trial name
- NCT06273228
- Testing
- Family Check-Up Online
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Oregon
Vasomotor Symptoms
Acupuncture in Menopause
The primary purpose of this study is to determine the effectiveness of acupuncture for treating vasomotor and other symptoms associated with menopause as acupuncture is generally practiced in the "real world" setting and to…
- Trial name
- AIM (NCT01276028)
- Testing
- Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Wake Forest University Health Sciences
Leukemia, Chronic Myeloid
Treatment Patterns and Outcomes Among Patients With Chronic Myeloid Leukemia (CML) in All Lines of Treatment
The aim of this study was to evaluate the real-world treatment patterns, healthcare resource use and costs among patients newly diagnosed with CML who were treated with tyrosine kinase inhibitors (TKIs) in first- and second-line…
- Trial name
- NCT07188428
- Where
- United States
- Volunteers
- 2,298 people
- Sponsor
- Novartis Pharmaceuticals
Lateral Ankle Sprain
Comparative Study of Two Radiological Modalities, Ultrasonography Versus Stress Radiography, in the Urgent Care and Prognosis of Lateral Ankle Sprain (TALOS)
The aim of our study is to determine the most efficient radiologic examination to assess the ankle sprain seriousness and so improve the therapeutic care.
- Trial name
- TALOS (NCT00639028)
- Testing
- Ankle echography, Ankle echography + stress radiography, stress radiography
- Where
- France
- Volunteers
- 390 people
- Sponsor
- University Hospital, Grenoble
Cirrhosis
Insertion Technique in Large Volume Paracentesis
The purpose of this study is to compare two different methods that are used for inserting the needle during paracentesis. One method is called the "coaxial insertion technique" and the other is called the "z-tract technique".
- Trial name
- NCT02310165
- Testing
- Z-tract Insertion Technique, Coaxial Insertion Technique
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Virginia
Chronic Kidney Diseases, Cachexia
CKD Cachexia and Gut Microbiome
Cachexia is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Cachexia is a complex syndrome, in which inflammation and retention of uremic toxins are two main…
- Trial name
- DYNAMICA (NCT06986265)
- Testing
- Collection of clinical data and biological sampling
- Where
- 2 sites in Belgium
- Volunteers
- 157 people
- Sponsor
- Université Catholique de Louvain
Emergence Agitation, Nasal Surgery
Emergence Agitation
The impact of sugammadex on agitation upon emergence following adult nasal surgeries is an issue which needs to be studied that links anesthetic management with postoperative recovery.
- Trial name
- Sugamadex (NCT07253428)
- Testing
- Neostigmine + Atropine, Sugamadex
- Where
- Saudi Arabia
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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