Clinical trials: Symptom
Stroke, Seizures
Epilepsy Watch After Vascular Events: Frequency, Outcomes, and Risk Markers
This research aims to determine the frequency of seizures in patients following a stroke, identify risk factors associated with post-stroke seizures, and characterize EEG changes linked to these seizures.
- Conditions
- Stroke, Seizures, EEG Power Spectra, Serum Biomarkers
- Trial name
- EY-WAVEFORMS (NCT06922734)
- Where
- Slovenia
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Intentional Injury
A WrapAround Case Management Program for Youth Injured by Violence
This is a feasibility study of a WrapAround Case Management Program for Youth Injured by Violence. Youth (aged 10-24) who have been injured by violence and visit the emergency department will be offered a support worker who will…
- Trial name
- NCT01751464
- Testing
- WrapAround Case Management
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Manitoba
Anxiety, Depression
Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)
This research study is aimed at understanding behaviors and brain circuits that relate to anxiety and depression. Our goal is to learn which circuits of the brain are involved in anxiety and how these circuits might affect daily…
- Trial name
- NCT02220309
- Testing
- Pramipexole Oral Tablet
- Where
- 3 sites in United States
- Volunteers
- 167 people
- Sponsor
- Stanford University
Blood Coagulation Disorders, Hemorrhage
Transfusion of Fresh Frozen Plasma in Non-bleeding Intensive Care Unit (ICU) Patients
With the aim to restrict inappropriate fresh frozen plasma (FFP) transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgroup of intensive care (ICU) patients undergoing an invasive…
- Trial name
- TOPIC (NCT01143909)
- Testing
- omitting FFP transfusion before an intervention
- Where
- 4 sites in Netherlands
- Volunteers
- 81 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery
The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury
In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery.
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery, Anesthesia, General, Anesthesia, Spinal
- Trial name
- NCT06343259
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Headache
A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.
To determine if the intravenous administration of Metoclopramide and diphenhydramine in combination can effectively treat headaches in pregnant patients in those refractory to acetaminophen when compared to codeine
- Trial name
- MAD (NCT02295280)
- Testing
- Metoclopramide, Diphenhydramine, Codeine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- St. Louis University
Relapsed/Refractory, Multiple Myeloma
A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-079 Administered Subcutaneously as a Single Agent in Participants With Relapsed/Refractory (r/r) Multiple Myeloma (MM)
The purpose of this study is to assess the safety and tolerability, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D) of TAK-079 monotherapy and when combined with a backbone regimen of pomalidomide and dexamethasone…
- Trial name
- NCT03439280
- Testing
- Mezagitamab, Pomalidomide, Dexamethasone
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Fibromyalgia
Investigation of AVACEN Thermal Exchange System for Fibromyalgia Pain
Hypothesis: Daily use of the AVACEN Thermal Exchange System for 4 weeks will show improved Fibromyalgia pain and functioning markers, as assessed by biomarkers and clinical and psychological assessment.
- Trial name
- AVACEN: TES (NCT01619579)
- Testing
- AVACEN Thermal Exchange System
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Avacen, Inc.
Primary Biliary Cholangitis
Clinical Study on the Treatment of Elevated Total Bilirubin in Primary Biliary Cholangitis With Baobao Dan Capsule
1. Explore the effect of Babaodan Capsule on the serum total bilirubin level of primary biliary cholangitis patients with elevated total serum bilirubin; 2.
- Trial name
- NCT06371196
- Testing
- Babaodan Capsule
- Volunteers
- 60 people
- Sponsor
- Mei Han
Insulin Resistance, Prediabetic State
Impact of Digital Therapeutic on Metabolic Parameters
The purpose of this prospective randomized controlled study is to evaluate the impact of a six-month digitally administered behavioral change program on body weight, glycemic control and other metabolic parameters in obese adults…
- Conditions
- Insulin Resistance, Prediabetic State, Diabetes Mellitus, Type 2, Obesity
- Trial name
- NCT04573296
- Testing
- Vitadio, Conventional high-intensity lifestyle intervention program
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Vitadio s.r.o.
C.Surgical Procedure, Stress
Music Therapy as an Adjunct in CIED Lead Extraction Procedures
The study will investigate possible effects of music therapy as an adjunct in an invasive cardiac procedure where infected or broken pacemaker leads, or leads from implantable cardioverter-defibrillators are removed from inside…
- Conditions
- C.Surgical Procedure, Stress, Pain, Procedural, Anxiety
- Trial name
- MATH (NCT04172662)
- Testing
- Facilitated Music Listening
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Oslo University Hospital
Tardive Dyskinesia
Efficacy, Safety, and Tolerability of NBI-1065890 Versus Placebo in Adults With Tardive Dyskinesia
The primary objective of this study is to evaluate the efficacy of NBI-1065890 compared with placebo for the treatment of tardive dyskinesia (TD) in adult participants.
- Trial name
- NCT07365462
- Testing
- NBI-1065890
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurocrine Biosciences
Gastroschisis
Clinical and Biological Outcomes of Human Milk and Formula Intake After Gastroschisis Repair
The purpose of this study is to determine which type of food results in a shorter hospital stay and better overall outcome for babies born with gastroschisis.
- Trial name
- NCT02575846
- Testing
- Enteral Intake - Human Milk, Enteral Intake - Formula
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University
End-stage Kidney Disease
Kinetics of Extracellular Vesicles in Hemodialysis
The aim of this observational study is to gain insight into the kinetics of extracellular vesicles (EVs), derived from both in- (i.e.
- Trial name
- NCT05957146
- Testing
- Routine hemodialysis
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Amsterdam UMC, location VUmc
Hernia, Ventral
A Study to Compare Ventral Incisional Hernia by Laparoscopic vs Open Repair With Mesh
The purpose of this research is to compare open ventral incisional hernia repair to the laparoscopic repair with respect to complications, recurrence, pain, return to normal activities of daily living, and return to work.
- Trial name
- NCT00240188
- Testing
- Open mesh repair of ventral incisional hernia, Laparoscopic mesh repair of ventral incisional hernia
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- US Department of Veterans Affairs
Airway Management
Apneic Intubation Critically Ill Children
This study compares the actual standard of care of intubation in Swiss pediatric intensive care units vs the use of apneic oxygenation using either high flow or low flow oxygen to prevent hypoxemia and to prolong apnea time…
- Trial name
- Penguin (NCT04890288)
- Testing
- Interventional randomized controled trial (RCT) comparing two oxygenation methods to reduce desaturation during intubation vs standard of care.
- Where
- 7 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obesity
Interdisciplinary Intervention in Patients With Obesity and Other Metabolic Diseases
The aim of the research study will be assess the effectiveness of a long-term interdisciplinary lifestyle in many aspects including food intake, psychological symptoms, physical activity habits, energy expenditure, body…
- Trial name
- NCT02573688
- Testing
- Interdisciplinary Therapy
- Where
- Brazil
- Volunteers
- 87 people
- Sponsor
- Federal University of São Paulo
Pancreatic Cancer
BYL719 in Combination With Gemcitabine and (Nab)-Paclitaxel in Locally Advanced and Metastatic Pancreatic Cancer
The main purpose of this study is to see primarily if BYL719 is safe to be given to patients in combination with gemcitabine and nab-paclitaxel.
- Trial name
- NCT02155088
- Testing
- BYL719, Gemcitabine, (nab)-paclitaxel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Emergency Department, Clinical Pharmacist
Integrating the Clinical Pharmacists Into Emergency Department Teams
The "Emergency Department (ED) Pharmacist" is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations.
- Trial name
- ED-PHARM (NCT04722588)
- Testing
- Introducing clinical pharmacists to the interdisciplinary ED team.
- Where
- 3 sites in Norway
- Volunteers
- 30,888 people
- Sponsor
- Hospital Pharmacy of North Norway Trust
Bacterial Infections
Effect of Bifidobacterium Breve PRL2020 (an Amoxicillin-clavulanate-resistant Strain) on Gastrointestinal Symptoms and Gut Microbiota Composition in Children Treated With Amoxicillin or Amoxicillin/Clavulanate
Amoxicillin or Amoxicillin/Clavulanic acid antibiotic therapy has been shown to be associated with disrupting the microbiota population particularly Bifidobacterium, which may have further GI clinical implications.
- Trial name
- NCT05840588
- Testing
- Antibiotic Treatment, Probiotic Bifidobacterium breve PRL2020 (Brevicillin®) treatment
- Where
- Italy
- Volunteers
- 121 people
- Sponsor
- Liaquat University of Medical & Health Sciences
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