Clinical trials: Symptom Management
Pulmonary Arterial Hypertension
Safety Evaluation of Inhaled Treprostinil Administration Following Transition From Inhaled Ventavis in Pulmonary Arterial Hypertension (PAH) Subjects
This is a 24-month, multi-center, prospective, open-label, safety evaluation in PAH subjects following transition from a stable dose of inhaled iloprost (Ventavis).
- Trial name
- NCT00741819
- Testing
- Inhaled treprostinil
- Where
- 15 sites in United States
- Volunteers
- 73 people
- Sponsor
- United Therapeutics
Depression
The PACE/PACENET Behavioral Health Laboratory Project
The purpose of the current project is to conduct a program evaluation that examines the impact of the The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program - a telephone-based clinical service designed to…
- Trial name
- SUSTAINII (NCT02440594)
- Testing
- Enhanced BHL Program Services, Standard BHL Program Services
- Where
- United States
- Volunteers
- 2,432 people
- Sponsor
- University of Pennsylvania
Acute Ischemic Stroke
A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients
This study tests the drug, Plasmin (Human), in patients with a stroke due to a clot in the middle cerebral artery (MCA). Plasmin is an enzyme that causes clot lysis by cleaving a clot component, fibrin.
- Trial name
- NCT01014975
- Testing
- Plasmin (Human)
- Where
- 23 sites in Australia, Austria and 4 more
- Volunteers
- 40 people
- Sponsor
- Grifols Therapeutics LLC
Alcohol Dependence, Alcohol Use Disorder
Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users
Our primary aim is to assess the feasibility of initiating treatment in the ED with extended-release naltrexone (XR-NTX) plus care management (CM) vs.
- Trial name
- NCT02445339
- Testing
- XR-NTX+CM (Extended-Release Naltrexone plus Care Management)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Heart Defects, Congenital
Efficacy And Safety Of Clopidogrel In Neonates /Infants With Systemic To Pulmonary Artery Shunt Palliation
Contemporary management of cyanotic congenital heart disease includes three stages of surgery. Incidence of shunt thrombosis and death between the two first stages of palliation remains important.
- Trial name
- CLARINET (NCT00396877)
- Testing
- Clopidogrel (SR25990)
- Where
- 31 sites in United States, Argentina and 29 more
- Volunteers
- 906 people
- Sponsor
- Sanofi
Kidney Failure, Chronic
Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation
Tacrolimus (Prograf) belongs to a class of medications known as the calcineurin inhibitors. It is a maintenance drug that is used to prevent rejection in kidney, liver, and heart transplant recipients.
- Trial name
- NCT00629122
- Testing
- Tacrolimus (Arm B), Clotrimazole Troche, Tacrolimus (Arm A)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Weill Medical College of Cornell University
Healthy
Bioenergetic Alterations After Exenatide Administration
The purpose of this study is to find out how exenatide causes weight loss. Specifically, the study is assessing how exenatide may change how people take in energy (energy intake), as well as how it may effect how people use…
- Trial name
- NCT00623545
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Chronic Kidney Diseases
Kidney Coordinated Health Management Partnership
As part of a 42-month pragmatic, cluster randomized trial in 1,650 primary care patients with high-risk Chronic Kidney Disease (CKD), the investigators will test the effectiveness of a multifaceted Electronic Health Record…
- Trial name
- Kidney-CHAMP (NCT03832595)
- Testing
- EHR-based PHM, Usual Care
- Where
- United States
- Volunteers
- 1,596 people
- Sponsor
- University of Pittsburgh
Breast Cancer, Stage IV Breast Cancer
Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer
RATIONALE: The primary tumor might be a source of re-seeding of distant sites and therefore elimination of this source of metastasizing cells by early local therapy may be of benefit.
- Trial name
- NCT01242800
- Testing
- palliative surgery, therapeutic conventional surgery, palliative radiation therapy
- Where
- 377 sites in United States, Canada and 3 more
- Volunteers
- 390 people
- Sponsor
- Eastern Cooperative Oncology Group
Chronic Low Back Pain
MEPS-Pain: Personalized Pain Self-management Planning by and for Veterans Pilot Study
Chronic low back pain is the #1 cause of disability and low quality of life in Veterans. Pain is a huge burden- stealing enjoyment, fulfillment, and time. Sometimes surgery, injections, or medications can help but sometimes not.
- Trial name
- MEPS-Pain (NCT04075487)
- Testing
- Web-module for patient education and planning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Cancer
Care Partners: Web-based Support for Caregivers of Veterans Undergoing Chemotherapy
Given the growing strain on the Veterans Administration resulting from increasing caseloads of cancer patients, interventions are badly needed that assist patients in managing their illness, improve quality of life and avoid…
- Trial name
- NCT00983892
- Testing
- Caregiver website
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- VA Office of Research and Development
GERD, Gastroesophageal Reflux Disease
LINX Reflux Management System in Subjects With GERD Who Have Previously Undergone a Laparoscopic Sleeve Gastrectomy
The purpose of this study is to evaluate the LINX device in patients who have previously undergone laparoscopic sleeve gastrectomy (LSG) for obesity and have chronic gastroesophageal reflux disease (GERD).
- Trial name
- RELIEF (NCT02429830)
- Testing
- LINX device
- Where
- 12 sites in United States
- Volunteers
- 30 people
- Sponsor
- Torax Medical Incorporated
Obesity
The EMBER Trial for Weight Management Engagement
This study will test whether EMBER, a self-help tool to increase weight loss treatment engagement, helps veterans engage in Veterans Health Administration (VHA) weight management programs.
- Trial name
- NCT05424081
- Testing
- EMBER, Control
- Where
- 2 sites in United States
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Advanced Cancers
The Use of Light Therapy for Managing Sleep Disturbances in Patients With Advanced Cancer
The goal of this research study is to learn if a type of light therapy can be used to help patients with advanced cancer who are having difficulty sleeping to sleep better.
- Trial name
- NCT01193530
- Testing
- Bright Light Therapy, Dim Red Light Therapy, Questionnaires
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Neuralgia, Postherpetic
A Study Assessing Efficacy of Brivaracetam in Subjects With Persistent Pain After Shingles (Post-herpetic Neuralgia)
Study will assess efficacy, safety and tolerability of brivaracetam in post-herpetic neuralgia (PHN). Duration of 7 weeks divided into 3 periods with no up-titration, nor down-titration.
- Trial name
- NCT00160667
- Testing
- Brivaracetam
- Where
- 50 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 152 people
- Sponsor
- UCB Pharma
Critical Illness, Anxiety
Self-management of Sedative Therapy by Ventilated Patients
The purpose of this randomized clinical trial is to test the efficacy of dexmedetomidine for the self-management of sedative therapy (SMST) in a sample of critically ill patients receiving mechanical ventilator support.
- Conditions
- Critical Illness, Anxiety, Respiratory Failure
- Trial name
- NCT02819141
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States
- Volunteers
- 161 people
- Sponsor
- Mayo Clinic
Pain
Topical Anesthetic Use In Pessary Management
The purpose of this study is to evaluate if lidocaine-prilocaine (EMLA 5%) cream can reduce pain and discomfort at the time of vaginal pessary removal and insertion.
- Trial name
- NCT02380742
- Testing
- lidocaine-prilocaine cream
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Loyola University
Metabolic Acidosis, Chronic Kidney Disease
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
This is a pilot, randomized, double-blinded, placebo-controlled, 12-month trial of 50 patients with CKD stage 3b-4 with metabolic acidosis to examine the effect of sodium bicarbonate therapy on cognitive and cerebrovascular…
- Conditions
- Metabolic Acidosis, Chronic Kidney Disease, Cognitive Dysfunction
- Trial name
- NCT04600323
- Testing
- Sodium Bicarbonate Tablets
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Colorado, Denver
COPD, COPD Exacerbation
Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, and over 90% of COPD-related deaths occurring in low- and middle-income countries (LMICs).
- Conditions
- COPD, COPD Exacerbation, COPD Exacerbation Acute, Pollution Related Respiratory Disorder
- Trial name
- NCT03984188
- Testing
- Theophylline ER, Standard of Care Treatment
- Where
- 2 sites in Uganda
- Volunteers
- 100 people
- Sponsor
- University of Miami
Constipation, Impaction, and Bowel Obstruction, Unspecified Adult Solid Tumor, Protocol Specific
S1316, Surgery or Non-Surgical Management in Treating Patients With Intra-Abdominal Cancer and Bowel Obstruction
This partially randomized clinical trial studies surgery or non-surgical management in treating patients with intra-abdominal cancer and bowel obstruction.
- Trial name
- NCT02270450
- Testing
- therapeutic conventional surgery, gastrointestinal complications management/prevention, quality-of-life assessment
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 221 people
- Sponsor
- SWOG Cancer Research Network
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