Clinical trials: Symptomatic Bradycardia, active
Bradycardia, Syncope
Comparison of the Efficacy and Safety of Cardioneuroablation to Permanent Pacing in Patients With an Implanted Pacemaker for Symptomatic Bradycardia.
Background Sinus node dysfunction (SND) and atrioventricular block (AVB) are significant diagnostic and therapeutic problems. The primary method of their treatment is cardiac pacemaker implantation (PM).
- Trial name
- GENTLE-PACE (NCT05896592)
- Testing
- Invasive electrophysiological study, Extracardiac vagal stimulation, Cardioneuroablation
- Where
- 2 sites in Poland
- Volunteers
- 99 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Symptomatic Bradycardia, Autonomic Nervous System Diseases
Basic and Clinical Study of Cardiac Ganglion Catheter Ablation for the Treatment of Significant Bradycardia
This study adopts a strategy combining basic research with clinical investigation to systematically explore the therapeutic value of cardioneuroablation in the treatment of vagally-mediated bradycardia.
- Trial name
- NCT07468383
- Testing
- Cardioneuroablation
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Beijing Anzhen Hospital
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
Vasovagal Syncope, AV Block-2Nd Degree-Type 1
Cardioneuroablation for Recurrent Vasovagal Syncope and Bradyarrhythmias: The CNA-FWRD Registry
The CNA-FWRD Registry is an international prospective observational multicenter registry of patients with symptomatic vasovagal syncope and bradyarrhythmias managed under routine care by medical therapy and radiofrequency…
- Conditions
- Vasovagal Syncope, AV Block-2Nd Degree-Type 1, Sinus Pause
- Trial name
- CNA-FWRD (NCT06166277)
- Testing
- Ablation procedure
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Rush University Medical Center
Symptomatic Bradycardia
Pacing Characteristics of a Conventional Bipolar
Study Title: Pacing characteristics of a conventional bipolar, active fixation pacing lead for left bundle branch area pacing in patients with symptomatic bradycardia Study Objectives: To characterize an approach for left bundle…
- Trial name
- NCT06011252
- Testing
- Solia S lead with any BIOTRONIK Pacemaker
- Where
- 5 sites in Taiwan
- Volunteers
- 134 people
- Sponsor
- Chang Gung Memorial Hospital
Symptomatic Bradycardia, Cognitive Function
PACE Cognition Proof-of-Concept Study
This proof-of-concept study will evaluate whether physiologic pacemaker programming improves cognitive function and health status in patients with symptomatic bradycardia who require permanent pacemaker implantation.
- Conditions
- Symptomatic Bradycardia, Cognitive Function, Pacemaker, Health Status
- Trial name
- NCT07769424
- Testing
- Physiologic Pacemaker Programming, Standard Pacemaker Programming
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Minnesota