Clinical trials: Symptomatic Carotid Stenosis
Stenoses, Carotid, Stroke
Anatomical Relationship Between Carotid Artery and Hyoid Bone in Stenotic and Non-stenotic Carotids
Ischaemic stroke is attributable to thromboembolism caused by carotid atherosclerotic disease in 18-25% of patients. Guidelines for prevention of stroke (especially carotid endarterectomy) in patients with carotid atherosclerotic…
- Trial name
- CAROTHYD (NCT05349526)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Atherosclerosis, Stroke
Carotid Revascularization Endarterectomy Versus Stenting Trial
The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of…
- Conditions
- Atherosclerosis, Stroke, Carotid Stenosis, Cerebral Infarction
- Trial name
- CREST (NCT00004732)
- Testing
- Carotid Endarterectomy (CEA), Carotid Artery Stenting (CAS)
- Where
- 115 sites in United States, Canada
- Volunteers
- 2,502 people
- Sponsor
- Rutgers, The State University of New Jersey
Oxidative Stress, vonWillebrand Disease
NON CANONICAL ACTIVATION OF BOOD COAGULATION
Cardiovascular diseases (CVD) are the major cause of mortality and morbidity worldwide and most of them are characterized by enhanced generation of active -thrombin (T) from the inactive Prothrombin zymogen (ProT), a reaction…
- Conditions
- Oxidative Stress, vonWillebrand Disease, Carotid Artery Stenosis Symptomatic, Carotid Artery Stenosis Asymptomatic
- Trial name
- NCA-BC (NCT07242521)
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Internal Carotid Artery Stenosis
SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy
SONOBIRDIE Trial is a randomized, single-blind, sham-controlled study designed for a demonstration of the safety and effectiveness of sonolysis (continual transcranial Doppler (TCD) monitoring) in reduction of risk of stroke or…
- Trial name
- SONOBIRDIE (NCT02398734)
- Testing
- sonolysis
- Where
- Czechia
- Volunteers
- 1,492 people
- Sponsor
- University Hospital Ostrava
Carotid Artery Plaque
99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
This was a single-center, single-dose, study comprising a Proof of Concept (PoC) part and a subsequent Phase II part. The study was being done to assess the ability of the radiotracer 99mTc-rhAnnexin V-128 to image…
- Trial name
- NCT02667457
- Testing
- 99mTc-rhAnnexin V-128
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Advanced Accelerator Applications
Carotid Artery Stenosis
Impact of Aspiration Thrombectomy During Carotid Stenting
The purpose of this study is to determine whether aspiration thrombectomy following carotid stent deployment will reduce the number of procedure related signals as identified by diffusion weighted MRI of the brain.
- Trial name
- NCT01550835
- Testing
- Emboshield NAV6® embolic protection system (Abbott Vascular, Santa Clara, CA)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Fogarty Clinical Research Inc.
Carotid Stenosis, Atherosclerosis
Revacept in Symptomatic Carotid Stenosis
Patients suffering from symptomatic carotid artery stenosis, transient ischemic attacks (TIAs), amaurosis fugax or stroke receive either Revacept (single dose) plus antiplatelet monotherapy or monotherapy alone.
- Conditions
- Carotid Stenosis, Atherosclerosis, Stroke, Transient-ischaemic Attack
- Trial name
- RevaceptCS02 (NCT01645306)
- Testing
- Revacept
- Where
- 12 sites in Germany, United Kingdom
- Volunteers
- 158 people
- Sponsor
- AdvanceCor GmbH
Carotid Stenosis
Determination of the Best Therapeutic Strategy, Interventional With Best Medical Management (BMM) Versus BMM Alone, for Patients With Symptomatic Moderate <70% Atherosclerotic Carotid Artery Stenosis: the SIMCA Multicenter Randomized Trial
Stroke is one of the leading causes of death and the main cause of long-term disability worldwide. A frequent cause is the narrowing of the carotid artery due to atherosclerosis, known as carotid artery stenosis.
- Trial name
- SIMCA (NCT07839390)
- Testing
- endarterectomy, stenting, Control group
- Volunteers
- 1,440 people
- Sponsor
- Central Hospital, Nancy, France
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Carotid Stenosis
Ultrasonographic Morphology Assessment of Low-grade Carotid Stenosis
Internal carotid artery (ICA) is intended to supply blood to brain. The carotid bulb located upstream of ICA origin is prone to atherosclerosis.
- Trial name
- QUAMUS (NCT05437991)
- Testing
- Independent morphological quantifications by echo-doppler using ECST method
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Carotid Stenosis
Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis
Remote ischemic conditioning (RIC) has emerged as a promising non-invasive strategy to protect the brain, with evidence suggesting its benefit in patients with carotid artery stenting (CAS).
- Trial name
- RICSICAS (NCT07412249)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Carotid Stenosis
CARMEDAS: Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis
PURPOSE: The purpose of this clinical trial is to study the cost-effectiveness ratios of diagnostic strategies for the imaging assessment of symptomatic carotid stenosis.
- Trial name
- NCT00131001
- Testing
- contrast-enhanced magnetic resonance angiography
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Carotid Stenosis
Alirocumab for Stabilisation of Symptomatic Vulnerable Carotid Plaque
CAROTID-STABILISE is a phase III, multicentre, randomised, double-blind, placebo-controlled trial evaluating whether alirocumab 150 mg subcutaneously every 2 weeks, added to high-intensity statin therapy, produces greater…
- Trial name
- CAROTID-STABIL (NCT07586540)
- Testing
- Alirocumab, Atorvastatin
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 280 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Ischemic Stroke
External Counterpulsation Therapy for Severe Steno-occlusive Intracranial Stenosis
Intracranial stenosis is prevalent among Asians and constitute a common cause of cerebral ischemia. While the best medical therapy carries stroke recurrence rates in access of 10% per year, intracranial stenting was associated…
- Trial name
- NCT03921827
- Testing
- Enhance External Counterpulsation Therapy
- Where
- Singapore
- Volunteers
- 130 people
- Sponsor
- National University of Singapore
Patients With Aterosclerotic Carotid Stenosis, Symptomatic Patients (Stenosis > 50%)
Carotid Revascularization With MicroNet Covered Stent Comparing Early Neurological Outcomes With Distal Versus Proximal EPS
The SIBERIA study demonstrated a clear advantage of CGuard stent implantation over the existing classical stent when using a distal anti-embolic device.
- Conditions
- Patients With Aterosclerotic Carotid Stenosis, Symptomatic Patients (Stenosis > 50%), Asymptomatic Patients (Stenosis ≥80%)
- Trial name
- SIBERIA-2 (NCT05257161)
- Testing
- Emboshield NAV6™, Mo.Ma™
- Where
- Russia
- Volunteers
- 366 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Carotid Artery Stenosis Symptomatic, Carotid Endarterectomy (CEA) Surgical Patients
Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry During Awake Carotid Endarterectomy
This study aims to better understand how well the brain is perfused (supplied with blood and oxygen) during a specific type of surgery called carotid endarterectomy (CEA), which is performed to prevent strokes in people with…
- Conditions
- Carotid Artery Stenosis Symptomatic, Carotid Endarterectomy (CEA) Surgical Patients, Cerebral Hypoperfusion
- Trial name
- NCT07150260
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Katip Celebi University
Carotid Artery Stenosis
Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting
The objective of this pivotal study is to evaluate the safety and efficacy of the CGuard™ Carotid Stent System in the treatment of carotid artery stenosis in symptomatic and asymptomatic patients undergoing carotid artery…
- Trial name
- C-Guardians (NCT04900844)
- Testing
- CGuard Carotid Stent implantation
- Where
- 18 sites in United States, Poland
- Volunteers
- 317 people
- Sponsor
- InspireMD
Asymptomatic Carotid Stenosis, Symptomatic Carotid Stenosis
Transcranial Doppler(TCD) Evaluation of High Intensity Transient Signals and Carotid Disease
Carotid Disease causes 10% of strokes. The Investigators are attempting to investigate the use of Transcranial Doppler to see if this is and effective, efficient, and/or valid way to identify individuals at highest risk for…
- Conditions
- Asymptomatic Carotid Stenosis, Symptomatic Carotid Stenosis, TCD, HITS
- Trial name
- TCD (NCT05829200)
- Testing
- Transcranial Doppler (TCD)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ochsner Health System
Stroke, Stenosis
Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis
The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to reduce the rate of recurrent ischemic…
- Trial name
- NCT00126139
- Testing
- Abciximab
- Where
- 5 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Carotid Stenosis, Ischemic Stroke
Symptomatic Carotid Outcomes Registry
The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications.
- Conditions
- Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
- Trial name
- SCORE (NCT05300737)
- Testing
- intensive medical therapy
- Where
- 18 sites in United States, Canada
- Volunteers
- 114 people
- Sponsor
- University of Maryland, Baltimore