Clinical trials: Symptomatic Knee Osteoarthritis
Osteo Arthritis of the Knee
A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis
The goal of this clinical trial is to test HL-01 in patients with knee osteoarthritis pain. The main question[s] it aims to answer are: Measure the change in average daily knee pain intensity scores from baseline to the end of…
- Trial name
- NCT07819461
- Testing
- Sodium hyaluronate solution - 3.36%, Sterile buffered solution
- Volunteers
- 704 people
- Sponsor
- IBSA Institut Biochimique SA
Knee Osteoarthritis
Symptomatic Efficacy of Diacerein in Knee Osteoarthritis
Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis.
- Trial name
- NCT00445276
- Testing
- Diacerein
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Laboratoires NEGMA
Osteoarthritis, Knee
Efficacy and Safety of Diclofenac DDEA 2.32 % in Patient Suffering From Knee Osteoarthritis (OA)
This study will evaluate the efficacy and safety of diclofenac DDEA 2.32 % in patient suffering from knee osteoarthritis (OA).
- Trial name
- NCT01967550
- Testing
- diclofenac diethylamine, DDEA 2.32% gel
- Where
- 5 sites in Germany
- Volunteers
- 304 people
- Sponsor
- Novartis
Arthritis, Osteo Arthritis of the Knee
Long Duration High Frequency Ultrasound for the Treatment of Osteoarthritis
The purpose of this study is to assess the ability of long-duration high-frequency continuous-wave therapeutic ultrasound to alleviate knee Osteoarthritis pain over an 12-week period.
- Trial name
- NCT07515872
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, Intra articular injection
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Osteoarthritis, Knee
Efficacy and Safety of Rebel Reliever Brace in Patients With Symptomatic Medial Knee Osteoarthritis
The purpose of the study is to evaluate the superiority of Rebel Reliever® knee brace + standard treatment versus standard treatment alone in terms of last 24-hour pain relief after 6 weeks.
- Trial name
- ROTOR (NCT02021136)
- Testing
- Rebel Reliever, Control
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Thuasne
Knee Osteoarthritis
EVI-01-IT Safety Study
Prospective, single arm, pilot study to assess the safety and tolerability of a single intra-articular injection of EVI-01 for the treatment of symptomatic knee osteoarthritis.
- Trial name
- NCT05422976
- Testing
- EVI-01
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Aptissen SA
Knee Osteoarthritis
Safety and Bone Health Study of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
The primary purpose of this phase 2, placebo-controlled, double-blind, parallel group study was to provide an initial safety evaluation of two intra-articular (IA) injections of SM04690 (each at the dose of 0.07mg per 2mL…
- Trial name
- NCT03727022
- Testing
- SM04690
- Where
- 13 sites in United States
- Volunteers
- 101 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis, Knee
A Study to Evaluate the Safety and Efficacy of 2ccPA in Patients With Symptomatic Knee Osteoarthritis
This phase I/II study aims to evaluate the safety of single doses of 2ccPA 4,800 μg and 7,200 μg (Phase I), as well as the safety and efficacy of multiple doses of 2ccPA (Phase II) in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT05807529
- Testing
- 2ccPA
- Where
- Taiwan
- Volunteers
- 136 people
- Sponsor
- Orient Europharma Co., Ltd.
Knee Cartilage Defects
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
This study will test whether CARTISTEM is safe and works better than debridement (a surgery that cleans out damaged tissue) for people with knee cartilage damage and osteoarthritis.
- Trial name
- CARTISTEM23-01 (NCT07339111)
- Testing
- CARTISTEM® + Debridement, Debridement
- Where
- 37 sites in United States
- Volunteers
- 300 people
- Sponsor
- Medipost, Inc.
Knee Osteoarthritis
Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide
This is a multi-center, randomized, double-blind, parallel group, active comparator controlled trial to evaluate the efficacy and safety of a single injection of Cingal for the relief of joint pain in subjects with OA of the knee.
- Trial name
- NCT03191903
- Testing
- Cingal, Monovisc, Triamcinolone Hexacetonide
- Where
- 19 sites in Hungary, Poland
- Volunteers
- 576 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Knee
A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA
The purpose of the study was to find out if the investigational treatment named QUC398 had beneficial effects on osteoarthritis (OA) knee pain and knee cartilage, and if it was safe and tolerated.
- Trial name
- NCT05462990
- Testing
- QUC398
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 101 people
- Sponsor
- Novartis Pharmaceuticals
Osteo Arthritis Knee
An Effectiveness and Safety 6 Months Study of 3 Injections One Week Apart of SYNOLIS VA 40/80 in the Treatment of Symptomatic Knee Osteoarthritis
Multicentre, independent assessment study on SYNOLIS VA 40/80 over a period of 24 weeks
- Trial name
- NCT05829850
- Testing
- SYNOLIS VA 40/80
- Where
- 3 sites in Poland
- Volunteers
- 51 people
- Sponsor
- Aptissen SA
Symptomatic Osteoarthritis of the Knee
Phase III Study on the Safety and Efficacy of a Single Intra-articular Administration of JTA-004 in Symptomatic Knee Osteoarthritis
Osteoarthritis is a degenerative, chronic, and progressive joint disease considered as the most common joint disorder worldwide. In healthy joints, there is a continuous process of natural breakdown and repair of cartilage.
- Trial name
- JTA-KOA2 (NCT04333160)
- Testing
- JTA-004, Hylan G-F 20
- Where
- 22 sites in Belgium, Czechia and 5 more
- Volunteers
- 746 people
- Sponsor
- Bone Therapeutics S.A
Knee Osteoarthritis
A Study on Visco-antalgic Intra-articular Administration in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) is the most common joint disease affecting millions of people around the world, for which there is unfortunately no cure.
- Trial name
- NCT02740231
- Testing
- JTA-004 intra-articular injection, Reference product intra-articular injection
- Volunteers
- 173 people
- Sponsor
- Bone Therapeutics S.A
Osteoarthritis of Knee
A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Patients With Symptomatic Knee Osteoarthritis
This is a, phase 1/2a trial, to assess the safety, tolerability, systemic exposure as well as preliminary efficacy following a single intra-articular injection of 3 dose levels of SYN321 in patients with symptomatic knee…
- Trial name
- NCT06989645
- Testing
- SYN321
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Synartro AB
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Osteo Arthritis Knee, Arthritis
Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
The purpose of this study is to assess the ability of long-duration low intensity therapeutic ultrasound (LITUS) to alleviate knee Osteoarthritis pain over a 24-week period.
- Trial name
- NCT06257537
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches
- Where
- 3 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Knee Osteoarthritis
GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using…
- Trial name
- MOTION (NCT05818150)
- Testing
- Embosphere Microspheres, Corticosteroid injection
- Where
- 27 sites in United States, Australia and 4 more
- Volunteers
- 264 people
- Sponsor
- Merit Medical Systems, Inc.
Symptomatic Knee Osteoarthritis
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
This was a double-blinded, two-arm, phase 2a study to assess efficacy, safety and tolerability of DFV890 in participants with symptomatic knee osteoarthritis.
- Trial name
- NCT04886258
- Testing
- DFV890
- Where
- 31 sites in United States, Argentina and 6 more
- Volunteers
- 115 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
Study of Cingal for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide at 39 Weeks Follow up
Extension study to Cingal 16-02 to obtain 39-week safety and efficacy follow-up data
- Trial name
- Cingal17-02 (NCT03390036)
- Testing
- Cingal, Monovisc, Triamcinolone Hexacetonide
- Where
- 17 sites in Hungary, Poland
- Volunteers
- 526 people
- Sponsor
- Anika Therapeutics, Inc.