Clinical trials: Symptomatic Knee Osteoarthritis
Osteoarthritis, Knee, Musculoskeletal Diseases
A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee
This clinical study is to evaluate the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic knee osteoarthritis (OA).
- Trial name
- NCT00131352
- Testing
- hylan G-F 20, Phosphate Buffered Saline
- Where
- 21 sites in Belgium, Czechia and 4 more
- Volunteers
- 253 people
- Sponsor
- Genzyme, a Sanofi Company
Knee Osteoarthritis
MRI Study to Evaluate the Safety and Efficacy of SM04690 for Knee Osteoarthritis
The purpose of this study was to evaluate the safety and efficacy of lorecivivint (LOR) injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT03706521
- Testing
- lorecivivint
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis, Knee
Long-term Safety and Performance of KiOmedine CM-Chitosan Supplementation in Advanced Symptomatic Knee Osteoarthritis
A single-blind randomized controlled design intended for the assessment of safety and performance of a single intra-articular injection of the IMD.
- Trial name
- PIONEER (NCT05214807)
- Testing
- KiOmedine® CM-Chitosan, Synvisc-One®
- Where
- Belgium
- Volunteers
- 104 people
- Sponsor
- Kiomed Pharma
Osteoarthritis, Knee
Comparative Study of Two Hyaluronic Acid Formulation in the Management of Knee Osteoarthritis
The objective of this randomized, double-blind, active-controlled, non-inferiority study is to compare the effectiveness and safety of a single injection of Hymovis ONE®, a sodium hyaluronate formulation, to Monovisc™, another…
- Trial name
- NCT06528600
- Testing
- Hymovis ONE, Monovisc
- Where
- 19 sites in Italy
- Volunteers
- 350 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis
A Study Evaluating the Safety, Tolerability, and Efficacy of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
The purpose of this study is to assess the efficacy, safety, and tolerability of three different strengths of SM04690 injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT02536833
- Testing
- SM04690
- Where
- 36 sites in United States
- Volunteers
- 455 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis of the Knee
Repeat Injection of Cingal® for Osteoarthritis of the Knee
The objective of this study is to evaluate the safety of an injection of Cingal® in subjects with Osteoarthritis (OA) of the knee who participated in Cingal 13-01, and who received either a Cingal, Monovisc, or saline injection…
- Trial name
- NCT02381652
- Testing
- Cingal
- Where
- 10 sites in Czechia, Hungary and 1 more
- Volunteers
- 242 people
- Sponsor
- Anika Therapeutics, Inc.
Knee Osteoarthritis
A Study to Evaluate the Clinical Performance and Safety of an Intra-articular Hyaluronic Acid in Knee Osteoarthritis
This is a study to evaluate the Clinical Performance and Safety of a single intra-articular (i.a.) injection of hyaluronic acid product (as HL-01) in the treatment of pain due to osteoarthritis (OA) of the knee.
- Trial name
- NCT03200288
- Testing
- HL-01: high and low molecular weight hyaluronic acid
- Where
- 31 sites in Belgium, Germany and 3 more
- Volunteers
- 692 people
- Sponsor
- IBSA Institut Biochimique SA
Osteoarthritis
A Trial of a Single Delivery of SB-061 in Osteoarthritis of the Knee
This study evaluates a novel agent, SB-061, for the treatment of osteoarthritis of the knee. Half of the patients will receive the agent via intra-articular injection and half will receive a placebo injection.
- Trial name
- MODIFY2 (NCT03231280)
- Testing
- SB-061
- Where
- 2 sites in Estonia
- Volunteers
- 60 people
- Sponsor
- Symic OA Co.
Knee Osteoarthristis
A Study to Investigate the Effectiveness, Safety, and Tolerability of MAG200 Solution for Intra-articular Injection Compared With Placebo in Participants Aged 35 to 75 Years of Age With Symptomatic Osteoarthritis of the Knee.
The purpose of this study is to confirm whether MAG200 (20M or 100M) will improve pain and function of participants with osteoarthritis of the knee compared with placebo. In addition, the two strengths of MAG200 will be compared.
- Trial name
- nexcell-OAK (NCT07106229)
- Testing
- allogeneic human adipose-derived mesenchymal stem cells
- Volunteers
- 573 people
- Sponsor
- Magellan Stem Cells
Knee Osteoarthritis
Safety and Efficacy of an Injectable Medical Device to Treat Knee Osteoarthritis
The purpose of this study is to determine whether MM-II is effective in the treatment of osteoarthritis, in direct comparison with an approved hyaluronic acid preparation.
- Trial name
- NCT01365260
- Testing
- MM-II, DurolaneTM
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Moebius Medical Ltd.
Osteoarthritis
Safety and Effectiveness of Monovisc® Injection for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular injection of Monovisc® hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT00653432
- Testing
- Monovisc®, Saline
- Where
- 31 sites in United States, Canada
- Volunteers
- 369 people
- Sponsor
- Anika Therapeutics, Inc.
Knee Osteoarthritis
Evaluation of the Effect of Pro Resolve® Sports on Treatment of Patients With Symptomatic Knee Osteoarthritis
The GAUDI study was a randomized, multicentre, double-blind, placebo-controlled, parallel-group pilot study conducted in 5 Spanish sites.
- Trial name
- GAUDÍ (NCT05633849)
- Testing
- SMP group
- Where
- 5 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Solutex GC S.L.
Osteoarthritis
Study of Safety and Efficacy of 6 mL Synvisc-One (Hylan G-F 20) in Indian Patients With Symptomatic Osteoarthritis of Knee(s) After Initial and Repeat Treatment
Primary Objective: To evaluate the safety and efficacy of a single 6 mL intraarticular (IA) injection of Synvisc-One in participants in India with symptomatic osteoarthritis (OA) of the knee(s).
- Trial name
- OASIS (NCT02389452)
- Testing
- Synvisc-One
- Volunteers
- 394 people
- Sponsor
- Genzyme, a Sanofi Company
Osteoarthritis of Knee
A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee
A Multi-Centre, Parallel, Double-Blind, Active comparator, Randomised phase III Clinical Trial
- Trial name
- NCT02893098
- Testing
- Humia inj., High hyal Plus inj.
- Where
- South Korea
- Volunteers
- 232 people
- Sponsor
- Huons Co., Ltd.