Clinical trials: Symptomatic Knee Osteoarthritis
Joint Disease
Autologous Plasma Rich in Growth Factors (PRGF) Treating the Symptomatic Knee OA
The purpose of this study is to evaluate the efficacy and safety of PRGF infiltrations in the treatment of knee osteoarthritis.
- Trial name
- NCT00782197
- Testing
- PRGF Intraarticular injection, Hyaluronic Acid Intraarticular injection
- Where
- 3 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Biotechnology Institute IMASD
Knee Osteoarthritis
Safety and Bone Health Study of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
The primary purpose of this phase 2, placebo-controlled, double-blind, parallel group study was to provide an initial safety evaluation of two intra-articular (IA) injections of SM04690 (each at the dose of 0.07mg per 2mL…
- Trial name
- NCT03727022
- Testing
- SM04690
- Where
- 13 sites in United States
- Volunteers
- 101 people
- Sponsor
- Biosplice Therapeutics, Inc.
Fibromyalgia, Knee Osteoarthritis
Efficacy of a Very Low Calories Ketogenic Diet in Obese Patients With Fibromyalgia or Symptomatic Knee Osteoarthritis
Adult patients with fibromyalgia or symptomatic knee osteoarthritis and comorbid obesity eligible to a very low calories ketogenic diet will be enrolled in the pilot study
- Trial name
- KD-FM-OA (NCT05848544)
- Testing
- Very low-calorie ketogenic diet for patients with symptomatic knee osteoarthritis, Very low-calorie ketogenic diet for patients with fibromyalgia
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Gonarthrosis, Obesity
Adipose Tissue and Symptomatic Gonarthrosis
1. Prevalence of osteoarthritis in France Osteoarthritis (OA) is a very common disease, affecting almost 15% of the population. It is responsible for a significant socio-economic cost in connection with the chronic and disabling…
- Trial name
- TAGS (NCT06314191)
- Testing
- blood sampling, knee radiography
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis, Knee
Comparative Study of Two Hyaluronic Acid Formulation in the Management of Knee Osteoarthritis
The objective of this randomized, double-blind, active-controlled, non-inferiority study is to compare the effectiveness and safety of a single injection of Hymovis ONE®, a sodium hyaluronate formulation, to Monovisc™, another…
- Trial name
- NCT06528600
- Testing
- Hymovis ONE, Monovisc
- Where
- 19 sites in Italy
- Volunteers
- 350 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis
Safety and Effectiveness of Monovisc® Injection for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular injection of Monovisc® hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT00653432
- Testing
- Monovisc®, Saline
- Where
- 31 sites in United States, Canada
- Volunteers
- 369 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Knee
A First-in-Human Study of XSTEM-OA in Patients With Knee Osteoarthritis
The aim of the study is to assess safety, tolerability and preliminary efficacy of XSTEM-OA when administered as a single intra-articular injection to patients with symptomatic knee osteoarthritis.
- Trial name
- NCT05344157
- Testing
- XSTEM-OA
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Xindu Pty Ltd
Knee Osteoarthritis
Patient-Reported Outcomes in Evaluating Lorecivivint (SM04690) for Moderate to Severe Knee Osteoarthritis (STRIDES-1)
This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intraarticularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic osteoarthritis…
- Trial name
- STRIDES-1 (NCT04385303)
- Testing
- Lorecivivint
- Where
- 76 sites in United States
- Volunteers
- 496 people
- Sponsor
- Biosplice Therapeutics, Inc.
Knee Osteoarthritis
The Impact of Therapeutic Alliance in the Rehabilitation of Knee Osteoarthritis.
The therapeutic alliance (TA) is the working relationship or positive social bond between the patient and the therapist. TA is based on collaboration, communication, empathy of the therapist and mutual respect.
- Trial name
- ALLIANCE (NCT04390932)
- Testing
- Enhanced TA, Limited TA, Therapeutic exercise protocol.
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- Universidad Catolica de Temuco
Osteoarthritis, Knee
Efficacy and Safety of Rebel Reliever Brace in Patients With Symptomatic Medial Knee Osteoarthritis
The purpose of the study is to evaluate the superiority of Rebel Reliever® knee brace + standard treatment versus standard treatment alone in terms of last 24-hour pain relief after 6 weeks.
- Trial name
- ROTOR (NCT02021136)
- Testing
- Rebel Reliever, Control
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Thuasne
Knee Osteoarthritis
Safety and Efficacy of an Injectable Medical Device to Treat Knee Osteoarthritis
The purpose of this study is to determine whether MM-II is effective in the treatment of osteoarthritis, in direct comparison with an approved hyaluronic acid preparation.
- Trial name
- NCT01365260
- Testing
- MM-II, DurolaneTM
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Moebius Medical Ltd.
Hip Osteoarthritis, Knee Osteoarthritis
Prevalence,Natural History,Prognosis Factor,QualityofLife,Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France
The aim of the project is to assemble and to follow on a 10-year period a nationwide representative sample of lower limb OA patients.
- Trial name
- KHOALA (NCT00481338)
- Testing
- X-rays, biological samples, medical information about osteoarthritis
- Where
- 6 sites in France
- Volunteers
- 878 people
- Sponsor
- Central Hospital, Nancy, France
Knee Osteoarthritis
Real-life Use of BENART TM in Patients With Symptomatic Knee Osteoarthritis
PMCF study to assess the effectiveness and safety of BENART in the treatment of symptomatic knee OA in a real-life clinical setting when used according to the instructions for use.
- Trial name
- NCT04757051
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- TRB Chemedica AG
Osteo Arthritis of the Knee
A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis
The goal of this clinical trial is to test HL-01 in patients with knee osteoarthritis pain. The main question[s] it aims to answer are: Measure the change in average daily knee pain intensity scores from baseline to the end of…
- Trial name
- NCT07819461
- Testing
- Sodium hyaluronate solution - 3.36%, Sterile buffered solution
- Volunteers
- 704 people
- Sponsor
- IBSA Institut Biochimique SA
Osteo Arthritis Knee, Arthritis
Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
The purpose of this study is to assess the ability of long-duration low intensity therapeutic ultrasound (LITUS) to alleviate knee Osteoarthritis pain over a 24-week period.
- Trial name
- NCT06257537
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches
- Where
- 3 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Knee Osteoarthritis, Symptomatic Knee Osteoarthritis
Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis
The purpose of this study is to asses the efficacy of a 4 week low-intensity resistance training program with concurrent application of partial blood flow restriction (PBFR) to the exercising limbs to improve quadriceps strength…
- Trial name
- PBFR2 (NCT01440972)
- Testing
- partial blood flow restriction (PBFR), low intensity resistance training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteo Arthritis Knee
"Ready-to-use" Intra-articular Formulation of Mesenchymal Stromal Cells
The goal of this clinical trial is to compare a newly developed off-the-shelf cryopreserved "ready to inject" Mesenchymal Stem Cell (MSC) product with the usual MSC preparation the investigators have used in knee osteoarthritis…
- Trial name
- PANLAR-II (NCT05751564)
- Testing
- "Ready to inject" Umbilical cord-derived Mesenchymal Stromal Cell (MSC) product, Resuspended Umbilical cord-derived Mesenchymal Stromal Cell (MSC) product
- Volunteers
- 60 people
- Sponsor
- Universidad de los Andes, Chile
Osteoarthritis of Knee
Efficacy and Safety of Sinovial®HL Single Injection in the Knee Osteoarthritis
The prevalence of knee osteoarthritis (OA) is rising worldwide, leading to disability and a reduced quality of life, particularly in elderly patients.
- Trial name
- NCT06652893
- Testing
- Sinovial
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Marcin Domżalski
Osteoarthritis of the Knee
Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis. It can cause pain, swelling, and reduced motion in the joints. That can reduce quality of life.
- Trial name
- NCT01119898
- Testing
- PENNSAID Gel, Vehicle
- Where
- 26 sites in United States
- Volunteers
- 260 people
- Sponsor
- Mallinckrodt
Osteoarthritis of Knee
Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)
This phase III clinical study will be conducted in Brazilian research sites. It will be included in the study 314 participants diagnosed with primary knee OA according to the classification criteria of the ACR.
- Trial name
- GLACIAL (NCT02830919)
- Testing
- Glucosamine and chondroitin sulfate combination (Eurofarma), Glucosamine and chondroitin sulfate combination (Zodic)
- Where
- 4 sites in Brazil
- Volunteers
- 627 people
- Sponsor
- Eurofarma Laboratorios S.A.