Clinical trials: Symptomatic Knee Osteoarthritis
Osteoarthritis,Knee
Can 3D Kinematic Parameters Assess the Symptomatic and Functional Severity of KOA?
There is little study focusing on kinematic parameters in the assessment of the symptomatic and functional severity of knee osteoarthritis (KOA).
- Trial name
- NCT03011112
- Testing
- Observational procedure
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Osteoarthritis
Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis
This was a multicenter, randomized, double-blind, placebo-controlled Phase IIb study evaluating intra-articular LNA043 in patients with knee osteoarthritis.
- Trial name
- ONWARDS (NCT04864392)
- Testing
- LNA043
- Where
- 75 sites in United States, Argentina and 13 more
- Volunteers
- 576 people
- Sponsor
- Novartis Pharmaceuticals
Gonarthrosis
Intraarticular Collagen in Patients With Gonarthrosis
The objective of this clinical trial is to verify the effectiveness of polyvinyl pyrrolidone collagen in all patients with symptomatic gonarthrosis grades II-IV in patients over 40 years of age.
- Trial name
- NCT06275880
- Testing
- Intra-articular infiltration of PVP Collagen, Rehabilitation
- Where
- Mexico
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Osteoarthritis, Knee
Long-term Safety and Performance of KiOmedine CM-Chitosan Supplementation in Advanced Symptomatic Knee Osteoarthritis
A single-blind randomized controlled design intended for the assessment of safety and performance of a single intra-articular injection of the IMD.
- Trial name
- PIONEER (NCT05214807)
- Testing
- KiOmedine® CM-Chitosan, Synvisc-One®
- Where
- Belgium
- Volunteers
- 104 people
- Sponsor
- Kiomed Pharma
Osteoarthritis of the Knee
Cabbage Leaf Wraps in Osteoarthritis of the Knee
This randomised controlled trial aims to investigate the efficacy of cabbage leaf cataplasms in the treatment of primary symptomatic osteoarthritis of the knee.
- Trial name
- KoGon (NCT02027792)
- Testing
- Cabbage leave wraps, Diclofenac Gel
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universität Duisburg-Essen
Knee Osteoarthritis, Pain, Joint
Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis
The aim of this clinical trial study is to compare the efficacy of Hyaluronic injection in patients with symptomatic knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Pain, Joint, Stiffness of Knee, Not Elsewhere Classified, Quality of Life
- Trial name
- NCT06279507
- Testing
- Sodium Hyaluronate, Normal Saline, Triamcinolone Acetonide 10mg/mL
- Where
- Thailand
- Volunteers
- 176 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Osteoarthritis, Knee
Efficacy Study of Intra-articular Hyaluronic Acid in the Knee Osteoarthritis
The purpose of this study is to prove the non-inferiority of the intra-articular injection of hyaluronic acid (Sinovial®) in the symptomatic treatment of knee OA in comparison to Synvisc®.
- Trial name
- NCT00556608
- Testing
- Sinovial® (syringe containing sodium hyaluronate solution), Synvisc® ( syringe containing Hylan G-F 20 solution)
- Where
- 20 sites in Czechia, France and 4 more
- Volunteers
- 381 people
- Sponsor
- IBSA Institut Biochimique SA
Osteoarthritis of Knee
A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Patients With Symptomatic Knee Osteoarthritis
This is a, phase 1/2a trial, to assess the safety, tolerability, systemic exposure as well as preliminary efficacy following a single intra-articular injection of 3 dose levels of SYN321 in patients with symptomatic knee…
- Trial name
- NCT06989645
- Testing
- SYN321
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Synartro AB
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Knee Osteoarthritis
Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide
This is a multi-center, randomized, double-blind, parallel group, active comparator controlled trial to evaluate the efficacy and safety of a single injection of Cingal for the relief of joint pain in subjects with OA of the knee.
- Trial name
- NCT03191903
- Testing
- Cingal, Monovisc, Triamcinolone Hexacetonide
- Where
- 19 sites in Hungary, Poland
- Volunteers
- 576 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Osteoarthritis, Knee
A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthritis of the Knee
Objective: Identifying the dose of EVI-01 with the best clinical response, balancing the efficacy, safety, and tolerability of the investigational product.
- Trial name
- NCT05337540
- Testing
- EVI-01, Active comparator Synvisc-One
- Where
- 2 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Aptissen SA
Obesity, Osteoarthritis
Symptomatic, Biomechanical and Radiographic Outcomes in Knee Osteoarthritis Following Gastric Bypass Surgery
Weight is a risk factor for knee osteoarthritis Knee osteoarthritis is associated with abnormal gait biomechanics Gait biomechanics are evaluated in gastric bypass patients before and after losing 100 pounds.
- Trial name
- NCT00194051
- Testing
- gastric bypass surgery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University Hospitals Cleveland Medical Center
Knee Osteoarthritis
Occupational Therapy-Delivered Cognitive Behavioral Therapy for Symptomatic Knee Osteoarthritis
Knee osteoarthritis (OA) affects 27 million US adults and is a leading cause of pain and disability. Non-pharmacological interventions are recommended but are underutilized.
- Trial name
- ENGAGE (NCT02498847)
- Testing
- ENGAGE
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Knee Osteoarthritis
Evaluation of the Prognostic Value of Biological Markers, Coll2-1 and Coll2-1NO2 in Patients With Symptomatic Knee Osteoarthritis
The purposes of this study are to assess the prognostic value of serum and urinary biomarkers Coll2-1 and Coll2-1NO2 at baseline, and their change over the first year, on the progression of knee osteoarthritis MRI scores at 12…
- Trial name
- PRODIGE (NCT02070224)
- Testing
- Serum and urine samples collections, Imaging (x-rays and MRI)
- Where
- 2 sites in Belgium, France
- Volunteers
- 120 people
- Sponsor
- Artialis
Osteoarthritis Of Knee
Trial to Assess the Structural Effect and Long-term Symptomatic Relief of Intra-articular Injections of Hyaluronic Acid in Primary Knee OA
The present study is designed to test the hypothesis that Intra-Articular Hyaluronic Acid (IAHA) is superior to placebo in slowing structural progression and on long term symptomatic effect in primary knee Osteoarthritis (OA)…
- Trial name
- ViscOA (NCT02280538)
- Testing
- Intra-Articular Hyaluronic Acid
- Where
- 2 sites in Portugal
- Volunteers
- 300 people
- Sponsor
- Universidade Nova de Lisboa
Osteo Arthritis Knee
Intra-articular Injection of Allogenic Lyophilized Growth Factors in Primary Knee Osteoarthritis
the study was conducted on 31-patients with symptomatic primary knee osteoarthritis. The patients were randomized into intervention and control groups. The control group was kept on their medications without intervention.
- Trial name
- NCT04331327
- Testing
- allogenic lyophilized growth factors
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Rasmia Elgohary
Knee Osteoarthritis, Degenerative Joint Disease of Knee
Genicular Artery Embolization for the Treatment of Knee Osteoarthritis
The purpose of this clinical research study is to examine whether Embozene treatment of the genicular artery is a safe and effective way to treat arthritic knee pain.
- Trial name
- GAE-OA (NCT03491397)
- Testing
- Embozene MicroSpheres
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Siddharth Padia, MD
Osteoarthritis
A Study Evaluating the Safety, Tolerability, and Efficacy of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
The purpose of this study is to assess the efficacy, safety, and tolerability of three different strengths of SM04690 injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT02536833
- Testing
- SM04690
- Where
- 36 sites in United States
- Volunteers
- 455 people
- Sponsor
- Biosplice Therapeutics, Inc.
Knee Osteoarthritis
Patient-Reported and Radiographic Outcomes in Evaluating Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis
This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intra-articularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic…
- Trial name
- STRIDES-Xray (NCT03928184)
- Testing
- Lorecivivint
- Where
- 99 sites in United States
- Volunteers
- 501 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis, Osteoarthritis, Knee
Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) of the knee is the most frequent cause of knee pain after the age of 50 years. OA is a joint disease characterised by articular cartilage loss associated with structural changes in the cartilage and adjacent…
- Trial name
- DISSCO (NCT02688400)
- Testing
- Diacerein, Celecoxib
- Where
- 22 sites in Austria, Belgium and 3 more
- Volunteers
- 380 people
- Sponsor
- TRB Chemedica International SA