Clinical trials: Symptoms, Affective
Schizophrenia Agitation, Schizo Affective Disorder
Evaluating Sublingual Dexmedetomidine For Moderate To Severe Agitation In Inpatients With Schizophrenia Or Bipolar Disorder
An open-label, randomized, active control inpatient trial to evaluate the efficacy and tolerability of sublingual dexmedetomidine for the treatment of agitation in inpatients with schizophrenia or bipolar disorder as measured by…
- Conditions
- Schizophrenia Agitation, Schizo Affective Disorder, Bipolar Disorder, Dexmedetomidine
- Trial name
- NCT06093451
- Testing
- Dexmedetomidine, Lorazepam 2 MG/ML
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Temple University
Depression, Anxiety
Affect Treatment for Depression and Anxiety (TAD Pilot)
The goal of this study is to determine whether subjects who do not show expected clinical improvement during the early course of positive affect treatment (PAT) would benefit from switching to an alternative psychosocial…
- Trial name
- NCT06488859
- Testing
- Positive Affect Treatment, Positive Affect Treatment and Negative Affect Treatment
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Hearing Loss, Hearing Loss, Sensorineural
Does Wearing Hearing Aids Impact the Affective State of Older Adults With Hearing Loss in Their Daily Lives?
The proposed field trial will clarify the real-world effectiveness of HAs in remediating deficits in emotion processing for older adults with mild-to-moderate hearing loss.
- Conditions
- Hearing Loss, Hearing Loss, Sensorineural, Emotions, Stress Physiology
- Trial name
- NCT06249685
- Testing
- Bilateral hearing devices
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Memphis
Bone Diseases, Metabolic, Depression, Involutional
Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in Depression
In this study researchers would like to learn more about the low levels of bone mineral density seen in approximately half of women in their forties diagnosed as currently having or previously had depression.
- Conditions
- Bone Diseases, Metabolic, Depression, Involutional, Osteoporosis
- Trial name
- NCT00001916
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Attention Training
Effects of Attention Training Interventions on Depression
The purpose of this study is to study the effects of attention training interventions on symptoms and brain function in major depressive disorder.
- Conditions
- Depression, Attention Training, Symptoms, Cognitive, Symptoms, Affective
- Trial name
- NCT04184206
- Testing
- attention training intervention 1, attention training intervention 2, attention training intervention 3
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mclean Hospital
Social Functioning, Alexithymia and Sense of Coherence , Bipolar Disorders
The Effect of Physical Exercises Program on Social Functioning, Alexithymia and Sense of Coherence Among Patients With Bipolar Disorders
The aim of this study is to: Investigate the effect of applying physical exercises program on social functioning, alexithymia and sense of coherence among patients with bipolar disorders Research Hypotheses Clients who…
- Trial name
- NCT05741281
- Testing
- Physical exercises program
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Mental Health Issue, Anxiety Disorders
Arts-based Social Prescribing for Mental Health
This is a parallel-group randomised-controlled trial aiming to assess the effect of exposure to the arts on mental health and wellbeing of community dwelling recipients of mental health care.
- Conditions
- Mental Health Issue, Anxiety Disorders, Affective Disorders, Affective Disorders, Psychotic
- Trial name
- AoP-II (NCT07137572)
- Testing
- Art Prescription
- Where
- Greece
- Volunteers
- 541 people
- Sponsor
- KAVADIA ELENI
Bipolar Disorder, Anxiety Disorders
Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder
Pediatric Bipolar Disorder (BD) is uncommon in children. Its symptoms include periods of manic behavior (being overly happy or giddy, feeling grandiose, feeling a decreased need for sleep, having too much energy, moving more than…
- Conditions
- Bipolar Disorder, Anxiety Disorders, Bipolar Affective Disorder, Bipolar Depression
- Trial name
- NCT00805493
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Mental Health (NIMH)
Pain, Touch
Sensory and Opioid Mechanisms of Affective Touch
Background: Medicines called opioids are used to treat pain. The body also produces opioids. These are called endorphins. Researchers want to learn more about how these natural opioids work.
- Trial name
- NCT03096353
- Testing
- Naloxone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Major Depression
Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene
The study evaluates the ABCB1-genotype dependent efficacy of a quick dose-escalation strategy within 28 days of treatment with approved antidepressants that are known substrates of the P-glycoprotein, an efflux pump of the…
- Trial name
- NCT02237937
- Testing
- Paroxetine, Sertraline, Citalopram
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HolsboerMaschmeyer NeuroChemie GmbH
Iron-deficiency, Iron Deficiency Anemia
Iron Deficiency in Female State Fair Attendees
This study aims to examine iron deficiency symptoms and biochemical iron status based on hemoglobin, hematocrit, ferritin, and total iron binding capacity in menstruating females.
- Conditions
- Iron-deficiency, Iron Deficiency Anemia, Iron Deficiency (Without Anemia)
- Trial name
- NCT03228173
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depression
Does Depression Impact Our Memory for Rewarding Experiences
When individuals experience depression, they may find that their brain does not work in the same way that they are used to. For example, sometimes the ability to remember things that happened during the day is not so good.
- Trial name
- NCT05276583
- Testing
- Motivated Learning Task
- Where
- Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Major Depressive Disorder, Minor Depressive Disorder
Evaluation of a Stepped Care Approach to Manage Depression in Diabetes
The study examines the efficacy of a stepped care approach for depressed diabetes patients (first study objective). 256 patients with diabetes and comorbid subthreshold or clinical depression will be randomly assigned to either a…
- Conditions
- Major Depressive Disorder, Minor Depressive Disorder, Sub-Threshold Depression, Diabetes Mellitus
- Trial name
- Ecce_homo (NCT01812291)
- Testing
- Step 1: Diabetes-Specific CBT (5 group sessions), Step 2: Depression-Specific CBT (6 single sessions), Step 3: Referral to Psychotherapist and/or Psychiatrist
- Where
- Germany
- Volunteers
- 260 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Multiple Sclerosis
Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event
Prevalence of alexithymia in multiple sclerosis (MS) is closed to 50% but is unknown in clinically isolated syndrome (CIS).The present study sought to characterize alexithymia in CIS patients and his link between psycho…
- Trial name
- ALEXCIS (NCT03796247)
- Where
- France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Lille
Bipolar Disorder
The MONARCA Project (MONitoring, treAtment and pRediCtion of bipolAr Disorder Episodes)
Bipolar disorder is associated with a high risk of relapse and hospitalisation and many patients do not recover to previous psychosocial function.
- Trial name
- MONARCA (NCT01446406)
- Testing
- MONARCA, NON-MONARCA
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Depressive Symptoms, Diabetes Mellitus
Evaluation of a Diabetes-specific Cognitive Behavioural Treatment for Subthreshold Depression
This work is supported by the "Kompetenznetz Diabetes mellitus (Competence Network for Diabetes mellitus)" funded by the Federal Ministry of Education and Research (FKZ 01GI0809).
- Trial name
- NCT01009138
- Testing
- Diabetes-Specific CBT (DS-CBT), Standard Diabetes Education
- Where
- Germany
- Volunteers
- 214 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Psoriasis
Clinical Assessment and Psychosocial Impact of Psoriasis
The purpose of this study is to explore the impact of plaque psoriasis on the different dimensions of patient life including psychological disorders, different types of addictions, and their consequences on health-related quality…
- Trial name
- EPIDEPSO (NCT01964443)
- Where
- 48 sites in Austria, Belgium and 10 more
- Volunteers
- 719 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Alexithymia
Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia
The syndrome of extremely restricted emotional competence, alexithymia, was originally conceptualized in psychoanalytic research and is now empirically and experimentally studied in clinical psychology and psychological medicine…
- Trial name
- ALEX (NCT00830752)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Misophonia Treatment
Instructed Cognitive Reappraisal in Reducing Affective, Behavioral and Psychophysiological Symptoms of Misophonia
Misophonia is a disorder causing intense reactions to specific sounds, disrupting daily life. Current treatments lack evidence-based support.
- Trial name
- NCT06372405
- Testing
- Cognitive reappraisal, Schultz Autogenic Training
- Where
- Poland
- Volunteers
- 108 people
- Sponsor
- University of Warsaw, Poland
Coccydynia, Chronic Pain
Alexithymia, Pain Intensity, Quality of Life, and Psychological Symptoms in Chronic Coccydynia Patients Scheduled for Ganglion Impar Block
Chronic coccydynia is characterized by pain localized to the coccygeal region that typically worsens with sitting, leading to notable impairments in functional performance and health-related quality of life.
- Conditions
- Coccydynia, Chronic Pain, Alexithymia
- Trial name
- NCT07828145
- Testing
- Psychometric and Clinical Survey Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Marmara University