Clinical trials: Symptoms, Behavioral
Online Self-help Transdiagnostic Psychological Intervention, Anxiety
Efficacy of Guided and Unguided Online Self-help Psychological Intervention
This study will examine the efficacy of guided and unguided online transdiagnostic self-help cognitive behavioral therapy (CBT) for reducing anxiety and/or depression symptoms in Hong-kong residents.
- Conditions
- Online Self-help Transdiagnostic Psychological Intervention, Anxiety, Depression
- Trial name
- NCT05160376
- Testing
- Self-help CBT with email reminder and text message, Feedback calls on participants' progress
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Neuro-Degenerative Disease, Dementia
Decreased Empathy and Emotion Recognition in Patients With Neurodegenerative Disease
This study evaluates an educational brochure tailored to caregivers of people with Alzheimer's disease, Parkinson's disease dementia, Lewy body disease, frontotemporal dementia, and vascular disease dementia.
- Conditions
- Neuro-Degenerative Disease, Dementia, Caregiver Burnout, Alzheimer Disease
- Trial name
- Empathy (NCT04635540)
- Testing
- Educational Brochure
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University Health Network, Toronto
Multiple Sclerosis, Depression - Major Depressive Disorder
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
Canada has one of the highest rates of multiple sclerosis (MS). MS patients experience disabling motor, visual, and sensory symptoms, and a high risk of comorbid major depressive disorder (MDD) and severe fatigue.
- Conditions
- Multiple Sclerosis, Depression - Major Depressive Disorder, Fatigue
- Trial name
- NCT07562074
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Type 2 Diabetes Mellitus, Obesity
Type 2 Diabetes and Obesity in Mexican Pimas: Gene-Environment Interaction
In 1995 we conducted a cross-sectional study to identify the effects of traditional and western environments on prevalence of type 2 diabetes mellitus (T2DM) and obesity in Pima Indians in Mexico and the United States.
- Trial name
- NCT01168297
- Where
- Mexico
- Volunteers
- 657 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Stress, Physiological, Stress, Psychological
Autonomic Modulation Training for Police Exposed to Post-Traumatic Stress Injuries
Police officers are exposed to hazardous, disturbing events that impose stress and long-term trauma. Upwards of 15-26% of public safety personnel (PSP) report one or more mental health symptoms.
- Trial name
- AMT (NCT05521360)
- Testing
- Autonomic Modulation Training
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Atrial Fibrillation, Overweight and Obesity
Super-Rehab: a Novel Approach to Treat Atrial Fibrillation
This study proposes to evaluate the effectiveness of a novel lifestyle intervention (Super Rehab), in addition to standard care, for patients with symptomatic atrial fibrillation (AF) requiring rhythm control strategy who are…
- Trial name
- SuRe-AF (NCT05596175)
- Testing
- Super Rehab
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Obesity, Time Restricted Feeding
Time Restricted Feeding on Weight Loss and Cardio-protection (TREATY Trial)
Time restricted feeding (TRF) is a novel type of intermittent calorie restriction diet that involves eating a daily period of 8 hours or less.
- Conditions
- Obesity, Time Restricted Feeding, Weight Loss, Calorie Restriction
- Trial name
- TREATY (NCT03745612)
- Testing
- Time restricted feeding, Continuous Energy Restriction
- Where
- China
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Depression in Adolescence, Suicide Prevention
Strategic Treatment and Assessment for Youth (STAY)
This multi-method, multi-phase pilot trial is designed to explore initial implementation and effectiveness of a theoretically-driven, culturally-tailored, measurement-based care (MBC) approach, Strategic Treatment Assessment for…
- Trial name
- STAY (NCT06515236)
- Testing
- Strategic Treatment Assessment for Youth (STAY), Measurement Based Care As Usual
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Yale University
Death Anxiety, Occupational Stress
Effect of Expressive Arts Therapy on Death Anxiety in Intensive Care Unit Nurses
This randomized controlled trial aimed to evaluate the effect of expressive arts therapy on death anxiety among intensive care unit nurses.
- Conditions
- Death Anxiety, Occupational Stress, Psychological Distress
- Trial name
- Expressive Art (NCT07462936)
- Testing
- Expressive Arts Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Depression
Volunteer-Delivery of Behavioral Activation
In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified a Behavioral Activation intervention to match the skill…
- Trial name
- NCT03371771
- Testing
- Volunteer-delivered Behavioral Activation, MSW-delivered Behavioral Activation
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Washington
Obesity, Overweight
Does Motivational Interviewing Improve Behavioral Weight Loss Outcomes for Obesity?
The purpose of this study is to determine whether adding motivational interviewing (MI) to a behavioural weight loss program (BWLP) results in improved weight loss for adults who are overweight or obese.
- Trial name
- BWLP+MI (NCT02649634)
- Testing
- Motivational Interviewing, Attention Control
- Volunteers
- 135 people
- Sponsor
- University of Calgary
Depression
Comparing Differing Financial Incentive Structures for Increasing Antidepressant Adherence Among Adults
The investigators will test using financial incentives by leveraging decision-making biases to improve adherence to antidepressants among adults newly prescribed antidepressants.
- Trial name
- ADAPT (NCT03441399)
- Testing
- Financial incentives
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Depression, Anxiety
A Randomized Controlled Trial of a VR Social Music-Movement Exergame for Depression and Anxiety in Young Adults
This randomized controlled trial aims to evaluate the effectiveness of a virtual reality (VR) music-movement exergaming intervention for improving social connectedness and psychological well-being among young adults.
- Trial name
- VR-MOVE (NCT07482852)
- Testing
- VR social musical exergame, VR solo musical exergame, Waitlist control
- Volunteers
- 130 people
- Sponsor
- Hunan University of Traditional Chinese Medicine
Obesity
Reduction in Cardiovascular Risk Factors and Visceral Adipose Tissue in Men: Separate Effects of Diet- and Exercise-Induced Weight Loss
The purpose of the trial was to examine the independent effects of equivalent diet- or exercise-induced weight loss on obesity and related cardiovascular health risk factors.
- Trial name
- NCT00664547
- Testing
- Diet Weight Loss, Exercise Weight Loss, Exercise Without Weight Loss
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University
Mental Stress, Hypertension
Impact of a Health and Mental Health Promotion Intervention Among Jordanians and Syrians.
Given the heightened risk of NCDs and mental health issues, it is critical for Jordanians and Syrian refugees to have access to prevention based health services.
- Conditions
- Mental Stress, Hypertension, Diabetes
- Trial name
- NCT03721848
- Testing
- Healthy community clinic NCD+MH, Healthy community clinic NCD
- Where
- Jordan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
HIV Infections, Pregnancy Related
Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe
The purpose of this study is to develop a multi-level PrEP adherence and persistence intervention as an adaptation of the TENDAI ('grateful' in Shona) program, a problem-solving approach to reduce depression and increase HIV…
- Conditions
- HIV Infections, Pregnancy Related, Depression, Anxiety
- Trial name
- TENDAI4PrEP (NCT06226155)
- Testing
- TENDAI4PrEP, Enhanced treatment as usual
- Where
- Zimbabwe
- Volunteers
- 165 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Depression
A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial
To compare the efficacy of brexpiprazole (flexible dose) with placebo as adjunctive therapy to an assigned open label antidepressant therapy (ADT) in the proposed subject population with MDD.
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- NCT01727726
- Testing
- Brexpiprazole, Seroquel XR
- Where
- 76 sites in United States, Canada and 5 more
- Volunteers
- 2,182 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression
Effectiveness of Group Interpersonal Psychotherapy in Treating Women With Prenatal Depression
This study will evaluate the effectiveness of group interpersonal psychotherapy for preventing postpartum depression in pregnant women with depression and for improving healthy outcomes in their babies.
- Trial name
- NCT00633178
- Testing
- Group interpersonal therapy (IPT), Treatment as usual (TAU)
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Persons With High Suicide Ideation or Attempts
Cognition, Metacognition, and Stigma in Patients With Suicidal Ideation
Deficits of executive function, meta cognition and stigma is known in suicidal ideation; however, their relationship is unknown.
- Trial name
- NCT06652815
- Testing
- Suicide ideation or suicide attempt
- Volunteers
- 212 people
- Sponsor
- University of Pittsburgh
Mechanical Low Back Pain, Chronic Pain
Comparison of the Effect of Spinal Manipulation by Gender
The purpose of the study was to compare and evaluate the effects of spinal manipulation in patients with chronic mechanical low back pain by gender.
- Conditions
- Mechanical Low Back Pain, Chronic Pain, Gender, Neuromuscular Subluxation of Joint
- Trial name
- CESMG (NCT06578208)
- Testing
- Spinal Manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- SEFA HAKTAN HATIK
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