Clinical trials: Symptoms, Cognitive
Gynecologic Cancer, Post-operative Pain
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
This study is a single-center, randomized, placebo-controlled, double-blind clinical trial. The purpose of this study is to evaluate the impact of pre-operative transverses abdominis plane (TAP) blocks on post-operative analgesia…
- Trial name
- NCT01444924
- Testing
- Bupivicaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Wisconsin, Madison
Opioid-Related Disorders, Neuralgia
Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection
Using combination of opioid analgesics and analgesics with different mechanism of action the investigators can decrease the consumption of opioid analgesics and their side effects.
- Trial name
- NCT02616523
- Testing
- Dexmedetomidine, Lidocaine, Fentanyl
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Physical Health Conditions
Therapist-Guided Internet-Delivered CBT for Chronic Conditions: Predictors of Change
Chronic health conditions are common, disabling, and often co-occur with depression and anxiety. Internet-delivered cognitive behaviour therapy (ICBT) reduces barriers to treatment and has been adapted for chronic conditions.
- Trial name
- NCT07233980
- Testing
- Internet-delivered CBT - Chronic Conditions Course (CCC)
- Where
- 2 sites in Canada
- Volunteers
- 260 people
- Sponsor
- University of Regina
Neurodevelopmental Disorders, Developmental Delay
Development of Motility and Cognition in Infants
PILKE study uses wearables for assessing motor development in infants in order to define functional growth trajectories in the normal infants and infants at risk of neurological compromise.
- Conditions
- Neurodevelopmental Disorders, Developmental Delay, Development, Infant, Child Development
- Trial name
- PILKE (NCT05527080)
- Testing
- physiotherapy, brace
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Postoperative Cognitive Dysfunction
Ketamine and Changes of the Short Portable Mental Status Questionnaire
Cognitive changes are related to aging, affecting the performance of older patients in the solution of problems and the execution of tasks.
- Trial name
- SPMSQ-E (NCT02049411)
- Testing
- Ketamine, physiological solution
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Anhedonia, Depression
Feasibility Randomized Controlled Trial Using a 'Leapfrog' Design
This study is a small-scale randomized controlled trial (RCT) using a 'Leapfrog' design (Blackwell, Woud, Margraf, \& Schönbrodt, 2019) with the aim of investigating feasibility of this design in the context of an RCT of an…
- Trial name
- NCT04791137
- Testing
- Imagery cognitive bias modification
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Ruhr University of Bochum
Urothelial Carcinoma
Study of Mocetinostat in Patients With Urothelial Carcinoma Having Inactivating Alterations of Specific Genes
Mocetinostat is an orally administered histone deacetylase (HDAC) inhibitor. This study is a Phase 2 trial evaluating the efficacy of mocetinostat in patients that have advanced urothelial carcinoma that has specific changes in…
- Trial name
- NCT02236195
- Testing
- Mocetinostat
- Where
- 14 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mirati Therapeutics Inc.
Down Syndrome, Down Syndrome (DS)
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
The purpose of this study is to evaluate whether levetiracetam can prevent epileptic seizures in patients with Alzheimer's disease associated with Down syndrome.
- Conditions
- Down Syndrome, Down Syndrome (DS), Down Syndrome (Trisomy 21), Alzheimer Dementia
- Trial name
- LESS-AD (NCT07234695)
- Testing
- Levetiracetam 500mg
- Where
- 5 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Anxiety Disorders and Symptoms
Mobile Cognitive Behavior Therapy Targeting Anxiety Disorders
This study aims to examine different ways of motivating people to make use of Maya, a mobile cognitive behavior therapy (CBT) program for adolescents and young adults experiencing anxiety symptoms, and to assess whether social…
- Trial name
- NCT05130281
- Testing
- Maya mobile app, Social Support, Gain Framed
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Weill Medical College of Cornell University
ADHD
Cognitive Training in Children With Attention Deficit/ Hyperactivity Disorder (ADHD)
The purpose of this study is to determine the effect of computer program C8 on specific cognitive functions, symptoms and functional outcome compared to treatment as usual in children with ADHD.
- Trial name
- NCT01752530
- Testing
- Computer program C8, Treatment as usual
- Where
- 3 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Region Syddanmark
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Down Syndrome
Physiological Abnormalities Associated with Down Syndrome
The overall goal of this study is to evaluate biomarkers of oxidative stress, mitochondrial function, and DNA methylation (epigenetics) in order to determine the extent to which these biomarkers are related to cognitive…
- Trial name
- NCT03087500
- Testing
- There is no other intervention, only clinical treatment.
- Sponsor
- University of Arkansas
Disc Herniation
Comparison of the Effectiveness of Reformer Pilates and Conventional Physiotherapy in Lumbar Disc Herniation
This study aims to examine the effects of Reformer Pilates on patient-reported outcomes such as pain level, fatigue, sleep quality, anxiety, kinesiophobia, and quality of life in individuals with lumbar disc herniation (LDH) and…
- Trial name
- NCT06846892
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yasemin Şahbaz
Pain, Post-operative
Evaluation of N1539 Following Major Surgery
The primary objective of this study is to evaluate the safety and tolerability of N1539 in a variety of post-surgical conditions.
- Trial name
- NCT02720692
- Testing
- N1539
- Where
- 32 sites in United States, Australia and 2 more
- Volunteers
- 722 people
- Sponsor
- Baudax Bio
Stressor, Individual, Alcohol Impairment
Neurobehavioral Changes Following Spaceflight Stressors
This study aims to investigate the impairing effects of known central nervous system (CNS) stressors in a controlled environment in order to predict and mitigate analogous risks in spaceflight.
- Conditions
- Stressor, Individual, Alcohol Impairment, Sleep Deprivation, Impairment, Cognitive
- Trial name
- NeuroSTAR (NCT07293494)
- Testing
- Alcohol Administration, Sleep Deprivation, Control
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Vegetative State, Minimally Conscious State
The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study
The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging…
- Trial name
- NCT03492294
- Testing
- functional magnetic resonance imaging
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Hangzhou Normal University
Depression
Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults
This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or…
- Trial name
- NCT00183729
- Testing
- Memantine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Eric Lenze
Bilateral Cataract, Charles Bonnet Syndrome
Patient Reported Visual Satisfaction Following Same Day or Delayed Bilateral Cataract Surgery
Cataract is currently the leading cause of visual impairment worldwide with age being the most common cause of lenticular opacification.
- Trial name
- CatquestCBS (NCT05069753)
- Testing
- Immediate sequential bilateral cataract surgery (ISBCS), Delayed sequential bilateral cataract surgery (DSBCS)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer, Pain, Postoperative
Comparative Sensory Mapping of Regional Anesthesia Techniques in Breast Cancer Surgery
Various regional anesthesia techniques, either individually or in combination, can be utilized for analgesia in breast cancer surgery.
- Trial name
- NCT06911892
- Testing
- Group Serratus Anterior Plane Block, Group Parasternal Block, Group Interpectoral+Pectoserratus Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Samsun University
Down Syndrome, Chromosome Abnormalities
Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters
Too much or too little genetic information (chromosome material) can cause abnormal development of the fetus or death. Each year approximately 2.5 million pregnant women are screened for Down Syndrome using invasive screening…
- Trial name
- NCT00006445
- Testing
- Ultrasound, Serum screen
- Where
- 10 sites in United States
- Volunteers
- 38,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)