Clinical trials: Symptoms and Signs
Parkinson's Disease, Levodopa Induced Dyskinesia (LID)
Efficacy and Safety of Amantadine Hydrogen Chloride (HCl) ER Tablets in Parkinson's Disease Subjects With LID
The purpose of this multi-center, randomized, double-blind, parallel-group, 26 week study is to compare the efficacy and safety of two different dose levels of Amantadine Extended Release Tablets to placebo for the treatment of…
- Trial name
- ALLAY-LID-II (NCT02153632)
- Testing
- amantadine HCl ER
- Where
- 56 sites in United States, Canada and 3 more
- Volunteers
- 135 people
- Sponsor
- Adamas Pharmaceuticals, Inc.
Pulmonary Disease, Chronic Obstructive
The Effect of Gait Training Using Different Slope Types on Balance in COPD Patients
Although COPD is basically a respiratory system disease, its effects are not limited to the respiratory system. In this context, one parameter affected in COPD patients is balance.
- Trial name
- NCT06644898
- Testing
- Level walking training, Downhill walking training, Uphill walking training
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Acibadem University
Anaemia
4 Week Correction Study in Subjects With Anemia Associated With Chronic Kidney Disease Who Are Not Undergoing Dialysis
This is a four-week Phase IIa, randomized, double-blind, placebo-controlled, parallel-group, multi-center study to evaluate the safety, efficacy and pharmacokinetics of GSK1278863 in approximately 68 subjects with anemia…
- Trial name
- NCT01587898
- Testing
- GSK1278863
- Where
- 55 sites in United States, Canada and 1 more
- Volunteers
- 72 people
- Sponsor
- GlaxoSmithKline
Bacterial Translocation, Surgical Site Infection
Plastic Wound Retractors and Bacterial Translocation in Abdominal Surgery
Hypothesis: Plastic wound retractors reduce passage of bacteria from the abdomen to the surgical incision site in abdominal surgery Currently, plastic wound retractors are used in abdominal surgery to facilitate access to the…
- Conditions
- Bacterial Translocation, Surgical Site Infection, Abdominal Surgery, Wound Infection
- Trial name
- NCT01007487
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- St Vincent's University Hospital, Ireland
Acute Pain
Taxane Acute Pain Syndrome (TAPS) in Patients Receiving Taxane Chemotherapy for Breast or Prostate Cancer
The purpose of this study is to document what course of action physicians choose for their patients when they develop taxane acute pain syndrome (TAPS) and to identify patients at the greatest risk of TAPS by examining specific…
- Trial name
- TAPSOTT14-06 (NCT02362087)
- Testing
- Quality of life and brief pain inventory
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Ottawa Hospital Research Institute
Cognitive Impairment, Mood Disorders
Performances of a Brief Assessment Tool for the Early Diagnosis of Geriatric Syndromes by Primary Care Physicians
The AGE (Active Geriatric Evaluation) aims to develop a brief assessment tool adapted to the primary care setting.
- Conditions
- Cognitive Impairment, Mood Disorders, Urinary Incontinence, Malnutrition
- Trial name
- NCT01816087
- Testing
- brief geriatric assessment
- Where
- Switzerland
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
End-Stage Renal Disease, Type 2 Diabetes Mellitus
A Double-Blind, Randomized, Placebo-Controlled Safety Study Evaluating the Effects of Residual Renal Function (RFF) in Patients With End-Stage Renal Disease and Type 2 Diabetes Mellitus on Peritoneal Dialysis
This study is a multi-center, double-blinded, randomized, study of bardoxolone methyl treatment in patients with End-Stage Renal Disease (ERSD) and Type 2 Diabetes Mellitus (T2DM) on peritoneal dialysis.
- Trial name
- NCT01576887
- Testing
- Bardoxolone Methyl 20 mg
- Sponsor
- Biogen
Chronic Pain, Mental Disorder
Early Detection of Mental Disorders in Adolescents With Chronic Pain: Creation of a Screening Tool for Use by the General Practitioner
This research aims to create a tool for detection of mental health disorders in adolescents with chronic pain. The first part is testing a screening questionnaire and comparing in with existing questionnaires.
- Trial name
- REPERADO (NCT04467229)
- Testing
- Focus group
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostatic Neoplasms, Lymphatic Metastasis
MR-Lymphography and Lymph Node Staging in Prostate Cancer
This proposal is targeted at all patients with prostate cancer who are candidates for either curative surgery or curative radiotherapy in whom lymph node staging is indicated.
- Trial name
- NCT00185029
- Testing
- Ferumoxtran-10 enhanced MRI (MRL)
- Where
- 3 sites in Netherlands
- Volunteers
- 396 people
- Sponsor
- Radboud University Medical Center
Genetic Predisposition, Metabolic Diseases
GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH
The goal of this research study is to evaluate the pathophysiologic mechanisms by which genetic variation impacts response to an FDA-approved medication commonly used to treat type 2 diabetes called oral semaglutide (Rybelsus)…
- Conditions
- Genetic Predisposition, Metabolic Diseases, Type 2 Diabetes
- Trial name
- GLUCOSE-MGH (NCT06003153)
- Testing
- oral semaglutide, Mixed Meal Tolerance Test (MMTT)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cocaine Dependence, Depressive Symptoms
Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in combination with gabapentin. The purpose of this study is to examine whether the antidepressant sertraline alone or combined with gabapentin…
- Trial name
- NCT00654953
- Testing
- sertraline, gabapentin
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Arkansas
Coronary Artery Disease, Coronary Artery Ectasia
Evaluation of Emotional Status and Coronary Flow Characteristics by TIMI Frame Count Method
This study evaluates the effects of emotional status on coronary flow in patients undergoing elective coronary angiography. Patients whom undergoing elective coronary angiography will fulfill the Beck Anxiety Inventory, Beck…
- Conditions
- Coronary Artery Disease, Coronary Artery Ectasia, Slow-Flow Phenomenon, Endothelial Dysfunction
- Trial name
- STRAIN-TIMI (NCT02831153)
- Testing
- coronary angiography
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Ertan YETKIN
Hearing Loss
Audiological Evaluation of Anesthetists
The investigators aim to investigate the effect of operating room noise on anesthetist hearing
- Trial name
- NCT03118102
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Advanced Cancer, Metastatic Cancer
Phase I Intratumoral Pbi-shRNA STMN1 LP in Advanced and/or Metastatic Cancer
This is a Phase I safety trial of bifunctional shRNA-STMN1 (pbi-shRNA™STMN1) BIV (bilamellar invaginated vesicle) lipoplex (LP), pbi-shRNA™ STMN1 LP administered by a single intratumoral (IT) injection.
- Conditions
- Advanced Cancer, Metastatic Cancer, Solid Tumors
- Trial name
- STMN1-LP (NCT01505153)
- Testing
- pbi-shRNA STMN1 LP
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gradalis, Inc.
Heart Failure, Delirium Confusional State
Delirium and Heart Failure
Biomarkers such as Systemic Immune-Inflammation Index (SII) and TG/Glucose Ratio (TyG) have shown promise in predicting delirium, reflecting the roles of inflammation and metabolic disturbances in its pathophysiology.
- Trial name
- NCT07302737
- Testing
- Comprehensive Geriatric Assessment, the Confusion Assessment Method (CAM test) or CAM-ICU, Delirium Rating Scale - Revised-98
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypothermia
Hypothermia in the Trauma Patient - When do Trauma Patients Get Cold?
The purpose of this study is to analyze changes in core body- and skin temperature during pre-hospital and early in-hospital treatment of multi-traumatized patients.
- Trial name
- NCT01006837
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Head and Neck Cancer, Thyroid Cancer
New MRI Biomarkers in Head and Neck Cancers
Magnetic resonance imaging (MRI) is a diagnostic technique that takes pictures of organs of the body. It uses magnetic fields and radio waves that cannot be felt.
- Trial name
- NCT03483337
- Testing
- MRI examinations
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Laparoscopic Gastrectomy, Ropivacaine
Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy
Visceral pain is obvious and lasts for a long time in patients after laparoscopic gastrectomy.Relieving the visceral pain is of great significance for patients' postoperative emotional experience, functional recovery and reducing…
- Trial name
- NCT06145945
- Testing
- 0.5% Ropivacaine, Saline
- Where
- China
- Volunteers
- 72 people
- Sponsor
- SanQing Jin
Ischemic Heart Disease, Stenotic Coronary Lesion
RESOLUTE ONYX China Single Arm Study
It is a single arm clinical evaluation of safety and efficacy of the Medtronic Resolute Onyx™ zotarolimus-eluting coronary stent system in subjects who are eligible for percutaneous transluminal coronary angioplasty (PTCA) in de…
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT03471845
- Testing
- Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
- Where
- China
- Volunteers
- 591 people
- Sponsor
- Medtronic Vascular
Hypoactive Delirium, Hyperactive Delirium
Delirium Prevention in Patients From the Intensive Care Unit (DELA)
"To determine the efficacy of program of prevention of delirium in critically ill patients from the intensive care units of Bucaramanga and Floridablanca.
- Conditions
- Hypoactive Delirium, Hyperactive Delirium, Delirium of Mixed Origin
- Trial name
- DELA (NCT03215745)
- Testing
- Delirium prevention program
- Where
- Colombia
- Volunteers
- 200 people
- Sponsor
- Universidad de Santander
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