Clinical trials: Symptoms and Signs
End Stage Renal Disease, Myocardial Microvascular Disease
Myocardial Microvascular Disease in ESRD
Cardiovascular diseases are the leading cause of mortality in patients with end stage renal disease (ESRD). They often have myocardial ischemia (a major predictor of mortality) on non invasive testing (Stress echocardiography…
- Trial name
- MICROCARD (NCT01291771)
- Testing
- Invasive FFR + CFR measurements are performed during coronary angiography using a pressure guide wire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Emphysema
A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema.
Rationale: The published clinical trials investigating the bronchoscopic lung volume reduction, showing important patient-related improvements in efficacy, led to the acknowledgement of the treatment in the GOLD-COPD2017…
- Trial name
- SOLVE (NCT03474471)
- Testing
- Pulmonary rehabilitation, EBV treatment
- Where
- 2 sites in Netherlands
- Volunteers
- 96 people
- Sponsor
- University Medical Center Groningen
HIV Seropositivity
Assessment of Age-related Hearing Loss in HIV-1 Patients
The ageing process is known to be accelerated in HIV-infected patients, compared to the general population. Normal age-related hearing loss (presbyacusia) is a frequent phenomenon, affecting more than 70% of people above 65…
- Trial name
- HELO (NCT02154971)
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Prostate Cancer, Oligometastasis
Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate…
- Conditions
- Prostate Cancer, Oligometastasis, Oligorecurrence, Recurrent Prostate Cancer
- Trial name
- VA STARPORT (NCT04787744)
- Testing
- PET-directed Local Therapy using Surgery, PET-directed Local Therapy using Radiation, Salvage Local Therapy for locally recurrent disease
- Where
- 20 sites in United States
- Volunteers
- 378 people
- Sponsor
- VA Office of Research and Development
Pulmonary Disease, Chronic Obstructive
The Purpose of This Study is to Evaluate the Spirometric Effect (Trough FEV1) of Umeclidinium/Vilanterol 62.5/25 mcg Once Daily Compared With Tiotriopium 18 mcg Once Daily Over a 24-week Treatment Period in Subjects With COPD
The purpose of this 24 week study is to evaluate the spirometric lung function effect (trough FEV1) of Umeclidinium/Vilanterol 62.5/25 once daily compared to Tiotropium 18 mcg once daily along with safety assessments in subjects…
- Trial name
- NCT01777334
- Testing
- Umeclidinium/Vilanterol 62.5/25 mcg, Tiotropium 18 mcg
- Where
- 70 sites in United States, Argentina and 7 more
- Volunteers
- 905 people
- Sponsor
- GlaxoSmithKline
Advanced (Unresectable or Metastatic) Melanoma
Study to Compare Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB11 Versus EU-/US-Opdivo® in Subjects With Previously Untreated Advanced [Unresectable or Metastatic] Melanoma
This is a randomised, multicentre, multinational, double-blind, integrated study to sompare the pharmacokinetics, efficacy, safety, and immunogenicity of MB11 versus Opdivo® in subjects with previously untreated advanced…
- Trial name
- NCT07221734
- Testing
- MB11 (Proposed Nivolumab Biosimilar), EU-Opdivo®, US- sourced Opdivo®
- Where
- 86 sites in Bosnia and Herzegovina, Brazil and 11 more
- Volunteers
- 632 people
- Sponsor
- mAbxience Research S.L.
Obesity
Zonisamide for Weight Reduction in Obese Adults
The primary aim of this study is to assess long-term weight loss efficacy of zonisamide relative to placebo in obese patients prescribed a dietary intervention.
- Trial name
- NCT00275834
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Duke University
Hemiplegia,Stroke, Respiratory, Neurophysiological Facilitation Techniques
The Effect of Neurophysiological Facilitation Techniques on Respiratory in Stroke
Hemiplegia is a disease with many complications in its clinical course. One of these complications is respiratory dysfunction. It is aimed to determine the respiratory function problems of patients with hemiplegia and to…
- Trial name
- NCT05601934
- Testing
- Neurophysiological Facilitation Techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Istinye University
Pain
Compare the Efficacy and Safety of Norspan to Tramadol/Acetaminophen With Prolonged Postoperative Pain (PASSION)
The purpose of this study is to compare the efficacy and safety of buprenorphine transdermal system to tramadol/acetaminophen.
- Trial name
- NCT01983111
- Testing
- buprenorphine, tramadol/acetaminophen
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Mundipharma Korea Ltd
Head and Neck Neoplasms, Recurrent Disease
Penpulimab in Combination With Cetuximab as First-line Treatment in R/M SCCHN
This trial is a multicenter, prospective, single-arm exploratory clinical study to evaluate the efficacy and safety of Penpulimab injection combined with cetuximab in the first-line treatment of recurrent/metastatic squamous cell…
- Conditions
- Head and Neck Neoplasms, Recurrent Disease, Metastatic Cancer
- Trial name
- NCT05260671
- Testing
- Penpulimab combined with cetuximab
- Where
- 2 sites in China
- Volunteers
- 48 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Benign Prostate Hyperplasia, Erectile Dysfunction
A Study of Tadalafil in Men With Benign Prostatic Hyperplasia (BPH) and Erectile Dysfunction (ED)
The purpose of this study is to see whether tadalafil can reduce the signs and symptoms in men with Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia-Lower Urinary Tract Symptoms (BPH-LUTS) and improve their quality of…
- Trial name
- NCT01937871
- Testing
- 5 mg Tadalafil, 0.2 mg Tamsulosin
- Where
- 14 sites in China
- Volunteers
- 909 people
- Sponsor
- Eli Lilly and Company
Cardiac Arrhythmia
EnSite Precision Observational Study
This document is a clinical investigation plan (CIP) for the EnSite Precision Observational Study. This clinical study is intended to quantify and characterize the usage of the EnSite Precision™ Cardiac Mapping System (Software…
- Trial name
- NCT03260244
- Testing
- cardiac mapping and radiofrequency ablation procedure
- Where
- 7 sites in United States
- Volunteers
- 1,065 people
- Sponsor
- Abbott Medical Devices
Postoperative Pain, Cardiac Surgery
Parasternal Block Versus Wound Infiltration for Pain After Median Sternotomy:A Salivary Opiorphin-Based Study
This study evaluated the effects of parasternal block and wound site infiltration on postoperative pain in patients undergoing median sternotomy.
- Conditions
- Postoperative Pain, Cardiac Surgery, Median Sternotomy
- Trial name
- NCT07621744
- Testing
- Parasternal blocks, Wound Site Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ataturk University
Asymptomatic Condition
Influence of Muscle Stretching and Neural Mobilizations on Lower Limbs Range of Motion in Asymptomatic Subjects.
First, this study aims to use the straight leg raising test (SLR) and the knee angle extension test (KEA) test associated to a structural differentiation to determine the limitation of the lower limb (muscular or nervous) in…
- Trial name
- NCT05899244
- Testing
- muscle streching exercice, Slider, Tensioner
- Where
- Belgium
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Liege
Sepsis, Shock
Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients
Investigators are conducting research about oxygen levels in the body and whether it is possible to use a device to measure oxygen in the body's tissues noninvasively, without blood draws or a catheter (a plastic tube placed in a…
- Trial name
- NCT01760044
- Testing
- Tissue oxygenation monitoring
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Sarcopenia, Child Development
Determination of Reference Values for Handgrip Strength and Bioimpedance Values in Healthy Turkish Children
In this study, our aim is to determine the reference values for the handgrip force and bioimpedance values in healthy Turkish children.
- Trial name
- NCT06001931
- Testing
- handgrip force and bioimpedance values in healthy Turkish children.
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Diabetes, Memory Impairment
Strengthening, Engaging, and Empowering Dyads Through Nutrition & Wellness
A meta-analysis of over 2.3 million individuals in 14 studies showed that individuals with type II diabetes (T2DM) are at a 60% increased risk for development of any dementia compared to those without T2DM.
- Trial name
- SEED (NCT06473129)
- Testing
- Food for Life Culinary Workshops
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Montefiore Medical Center
Endometriosis, Pain
Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain
The goal of this research is to improve pain outcomes for the over 500K Canadian women, girls and gender-diverse individuals who are newly diagnosed with endometriosis each year.
- Trial name
- NCT06333353
- Testing
- Real RepetitiveTranscranial Magnetic Stimulation 5 sessions, Real RepetitiveTranscranial Magnetic Stimulation 10 sessions
- Where
- Canada
- Volunteers
- 152 people
- Sponsor
- University of Ottawa
Low Back Pain
Effects of Kinesiotaping and Electrical Muscle Stimulation on Low Back Pain and Disability
To compare the effects of kinesiotaping and electrical muscle stimulation on low back pain and disability associated with diastasis recti.
- Trial name
- NCT05834153
- Testing
- kinesiotaping, electrical muscle stimulation
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Epileptic Seizure, Intracranial Tumor
Our Anesthesia Experience During MRI Scan
In this study we aim to investigate the relationship between our anesthesia practice and post procedure complications after MRI scanning with sedation. This is a retrospective, single center observational study.
- Conditions
- Epileptic Seizure, Intracranial Tumor, Intracranial Hypertension, Intracranial Aneurysm
- Trial name
- NCT03123302
- Where
- Turkey (Türkiye)
- Volunteers
- 977 people
- Sponsor
- Akdeniz University
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