Clinical trials: Symptoms and Signs
Diabetes Mellitus, Type 2, Obesity
Microbiome and Health Indicators in People With Obesity, Prediabetes and Type 2 Diabetes Undergoing a Lifestyle Intervention
The incidence of type 2 diabetes worldwide is growing rapidly, being one of the fastest growing global health emergencies of the 21st century according to the International Diabetes Federation.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, PreDiabetes
- Trial name
- MicrobiAr (NCT05372445)
- Testing
- Non-intensive intervention, Intensive intervention
- Where
- Argentina
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Alopecia Scar
Treatment of Alopecic Scars by Follicular Unit Extraction Hair Transplantation
This study aim: is to completely hide the alopecic scars in a way that it will not be visible.
- Trial name
- NCT06145672
- Testing
- follicular unit extraction and implantaion
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ankle Injuries and Disorders
Effect of Manual Therapy and Inmediately Application of Plantar Orthoses
Limitation of ankle dorsiflexion is directly related to pronated foot. For its treatment, plantar orthoses and manual therapy are used.
- Trial name
- NCT05847972
- Testing
- MWM (Mobilization with movement), Plantar orthoses
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Tracheo Esophageal Fistula, Congenital Diaphragmatic Hernia
Cerebral Blood Flow in Neonates During Thoracoscopic Surgeries
the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during…
- Trial name
- NCT04507295
- Testing
- cerebral oximetry ( INVOS 5100 )
- Volunteers
- 30 people
- Sponsor
- Cairo University
Myofascial Pain Syndromes, Low Back Pain
Radial Extracorporeal Shock Wave Treatment (rESWT) of Myofascial Pain Syndrome in Low Back Pain
The purpose of this study is to evaluate the efficacy of treatment of radial shockwave in myofascial pain syndrome in the lumbar region compared to placebo through questionnaires and imaging exams.
- Conditions
- Myofascial Pain Syndromes, Low Back Pain, Lumbago
- Trial name
- NCT01835795
- Testing
- Swiss DolorClast® CLASSIC applicator
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Musculoskeletal Pain
Transcultural Adaptation and Validation to Spanish of the OSPRO Questionnaires
Clinical guidelines for managing musculoskeletal pain recommend first, assessing and identifying any signs of severe physical conditions (i.e."red flags") and then, asessing the psychosocial prognostic factors of poor outcomes…
- Trial name
- SpanishOSPRO (NCT05869695)
- Testing
- OSPRO-ROS Questionnaire, OSPRO-YF Questionnaire
- Where
- 2 sites in Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Stroke, Gait Disorders, Neurologic
High Vs Low Intensity Virtual Reality Gait Training in Individuals with Chronic Stroke
The purpose of this pilot study is to investigate the feasibility of 1) providing virtual reality walking training using a custom developed setup able to be replicated in routine clinical practice and 2) combining the virtual…
- Trial name
- NCT06522477
- Testing
- Virtual reality gait training
- Where
- United States
- Sponsor
- Indiana University
Intracerebral Hemorrhage
Edaravone Dexborneol for Treatment of Hypertensive Intracerebral Hemorrhage
pending
- Trial name
- ED-ICH (NCT04714177)
- Testing
- Edaravone Dexborneol
- Volunteers
- 390 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Obesity, Insulin Resistance
Regional Fat Depots and Insulin Resistance
The biological basis for insulin resistance associated with obesity is unknown. By studying equally-overweight/obese individuals who are either insulin resistant or insulin sensitive, the investigators will compare…
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01336777
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Stanford University
Shoulder Arthroscopy, İnterscalene Brachial Plexus Block
Comparison of Postoperative Analgesic Efficacy of SPSIPB and Combination of IBPB and SCPB
Shoulder arthroscopy is one of the frequently performed surgical procedures today. After shoulder surgery, ensuring sufficent analgesia is necessary for both the patient's comfort and for the early and regular performance of the…
- Conditions
- Shoulder Arthroscopy, İnterscalene Brachial Plexus Block, Superficial Cervical Plexus Block, Serratus Posterior Superior Intercostal Plane Block
- Trial name
- NCT06660875
- Testing
- Serratus posterior superior intercostal plane block, Interscalene brachial plexus block and superficial cervical plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Hypertrophic Scar
A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults
The purpose of this study is to determine the effectiveness of RXI-109 in reducing the recurrence of hypertrophic scar formation following elective revision of a pre-existing hypertrophic abdominal scar.
- Trial name
- NCT02030275
- Testing
- RXI-109
- Where
- 5 sites in United States, Honduras
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- RXi Pharmaceuticals, Corp.
Gall Stones
Prospective Evaluation of Residual Bile Duct Stone by Peroral Cholangioscopy After Conventional ERCP
Gallstone disease affects over 20 million Americans. Among patients with gallbladder disease, the prevalence of choledocholithiasis (stones in the bile duct) is estimated to be 10-20%.
- Trial name
- NCT03482375
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Northwell Health
Diabetes Mellitus, Type 2
Comparative Metabolomics in Diabetes Patients From Sri Lanka and Switzerland
This study is a case-control study, where the assumed different subtypes of type 2 diabetes in people of Tamil ethnicity and Swiss origin living in Bern, Switzerland will be examined by measuring the metabolite profiles and the…
- Trial name
- NCT05787457
- Testing
- Clinical examination, Blood testing, MRI
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Post Operative Pain
Relationship Between Acute Phase Markers and Post-operative Pain in Laparoscopic Cholecystectomy: An Observational Study
Many patients undergoing laparoscopic cholecystectomy are prone to developing acute and chronic post-operative pain. The aim of the study is to show a possible correlation between pain and acute phase proteins in order to…
- Trial name
- NCT06375057
- Testing
- laparoscopic cholecystectomy
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- University of Roma La Sapienza
Major Abdominal Surgery, Atelectasis
Optimal Interval for Periodic Alveolar Recruitment Maneuvers Achieving 90% Lung Re-expansion During Intraoperative Ventilation
This study aims to determine the optimal interval for periodic alveolar recruitment maneuvers (PARM) that can achieve effective lung re-expansion in 90% of patients undergoing intraoperative mechanical ventilation during…
- Conditions
- Major Abdominal Surgery, Atelectasis, Lung-protective Ventilation, Lung Ultrasound Score
- Trial name
- NCT07239557
- Testing
- Different interval of PARM
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Asthma, Obesity
Effects of Weight Loss in Obese Difficult-to-treat Asthmatics
Sixty percent of patients with difficult to control asthma seen in our outpatient clinic are obese. The impact of weight reduction in this subpopulation of asthmatics has not been studied.
- Conditions
- Asthma, Obesity, Weight Loss
- Trial name
- NCT01047657
- Testing
- Low caloric diet plus orlistat and sibutramine
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Sao Paulo General Hospital
Advanced Melanoma, Metastatic Melanoma
Safety and Efficacy of Recombinant Humanized Anti-PD-1 mAb for Patients With Locally Advanced or Metastatic Melanoma
This is a multi-center, open-label, phase 2 study evaluating the humanized anti-PD-1 antibody JS001, as a monotherapy in patients with locally advanced or metastatic melanoma who have failed in routine systemic treatment.
- Trial name
- NCT03013101
- Testing
- humanized anti-PD-1 monoclonal antibody toripalimab
- Where
- 6 sites in China
- Volunteers
- 128 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Chronic Pain
Pain Response Evaluation of a Combined Intervention to Cope Effectively
The purpose of this research is is to determine if the combination of non-opioid medication (duloxetine) and web-based pain-coping skills training (PCST) is beneficial for individuals with chronic musculoskeletal pain (CMP).
- Trial name
- PRECICE (NCT04395001)
- Testing
- duloxetine, Web-based Cognitive Behavioral Therapy (CBT), Nurse-delivered Motivational Interviewing
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Wake Forest University Health Sciences
Primary Osteoarthritis, Cartilage Degeneration
DEXA Bone Density Analysis of the CoreHip® Prosthesis System
The goal of this interventional post-market follow-up study is to evaluate radiological changes in the diaphyseal bone density (Gruen Zones 3 and 4) within 24 months postoperative in patients treated with CoreHip® primary…
- Conditions
- Primary Osteoarthritis, Cartilage Degeneration, Osteoarthritis, Hip, Inflammatory Arthritis
- Trial name
- CODEX (NCT06632301)
- Testing
- Primary hip replacement with cementless stem
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Aesculap AG
Constipation, Pain
Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients
The primary objective of this trial is to study the efficacy of oxycodone/naloxone prolonged release tablets (OXN PR), compared to oxycodone prolonged release tablets (Oxy PR), for the reduction of the intensity of opioid-induced…
- Trial name
- OXN3505 (NCT01014559)
- Testing
- Oxycodone Naloxone, Oxycodone PR Tablets
- Where
- France
- Volunteers
- 225 people
- Sponsor
- Mundipharma SAS
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