Clinical trials: Symptoms and Signs
Mental Disorder, Symptoms and Signs
A Useful Support System for Psychiatric Diagnostics and Follow-up in Adult Psychiatry and Primary Care (ASPP)
Psychiatric diagnostics involve collecting information about a patient's symptoms, age of onset, development over time, relation to external stress, and ability to function and experience suffering.
- Trial name
- ASPP (NCT05827406)
- Where
- 5 sites in Sweden
- Volunteers
- 2,200 people
- Sponsor
- Karolinska Institutet
Respiratory Symptoms, Autonomic Nervous System Dysfunction
CoVID-19 Evaluation of Neurological and Autonomic Nervous System Troubles in Intensive Care Unit Patients
Since the spread of the COVID-19 disease, several studies have reported the presence of neurological symptoms in patients infected with SARS-CoV-2 such as dysgeusia, hypo or anosmia, hypopsia, the presence of headaches or…
- Trial name
- COVENANT-ICU (NCT06060795)
- Testing
- Electro-conductance measurement
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
Sexuality, Sexual Dysfunction
Sexual Health in Patients With Hematologic Malignancies
Sexual wellbeing is an integral component of psychosocial and physical wellbeing. Cancer-related symptoms, treatment side-effects and psychosocial distress have significant impact on sexual well-being and sexual health.
- Conditions
- Sexuality, Sexual Dysfunction, Psychological, Quality of Life
- Trial name
- NCT05222282
- Testing
- Sexual Health
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hearing Loss
AM-111 in the Treatment of Acute Inner Ear Hearing Loss
The purpose of this research study is to test the effectiveness and safety of the study drug, AM-111. AM-111 is tested for the treatment of sudden sensorineural hearing loss where the cause is unknown.
- Trial name
- HEALOS (NCT02561091)
- Testing
- AM-111 0.4 mg/ml, AM-111 0.8 mg/ml
- Where
- Bulgaria
- Volunteers
- 256 people
- Sponsor
- Auris Medical AG
Pain, Postoperative, Postoperative Complications
Methadone in Cystectomy Patients
The role of a single-dose intraoperative methadone on postoperative pain and opioid consumption in patients undergoing Surgeon Accuracy Robot Assistant cystectomy.
- Conditions
- Pain, Postoperative, Postoperative Complications, Pathologic Processes, Bladder Cancer
- Trial name
- METAMORF (NCT04475029)
- Testing
- Methadone, Morphine
- Where
- Denmark
- Volunteers
- 114 people
- Sponsor
- University of Aarhus
Symptoms and Signs Involving Cognition Perception Emotion & Behaviour, Abdominal Cancer Patients
Investigating the Effect of Simulated Live Piano Music on Preoperative Cancer Patients, Health Care Providers and Hospital Volunteers Using Validated Questionnaires and Proteomic Analysis
The goal of this research study is to learn if simulated live piano music can change the amount of stress felt in patients with cancer before surgery, health care providers caring for cancer patients, and/or hospital volunteers.
- Trial name
- NCT03239587
- Testing
- Musical Intervention, Blood Draws, Questionnaires
- Sponsor
- M.D. Anderson Cancer Center
Carpal Tunnel Syndrome, Symptoms and Signs
Reliability and Validity of the Turkish Version of the 6-item Carpal Tunnel Syndrome Symptoms Scale
Carpal tunnel syndrome (CTS) is a common condition that affects the median nerve that usually cause numbness, tingling, pain, and weakness in the hand and fingers.
- Trial name
- NCT05927896
- Testing
- 6-item Carpal Tunnel Syndrome Symptoms Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Low Back Pain, Mechanical, Symptoms and Signs
Validity and Reliability of the Turkish Version of the Low Back Activity Confidence Scale (Lobacs)
Patients will be recruited from the Outpatient Department of Physical Medicine and Rehabilitation, Kestel State Hospital, who have been diagnosed with mechanical LBP for the past 3 weeks (physical examination, neurological…
- Trial name
- NCT05927909
- Testing
- Low Back Activity Confidence Scale (Lobacs)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bursa City Hospital
Indication for ElectroCardioGram
Electrocardiogram in General Practice : the EGG Study
Existing resources to assist interpretation of ElectroCardioGram (ECG) in general practice provide specialized and comprehensive reading based on pathologies and ElectroCardioGram (ECG) signs rather than ElectroCardioGram (ECG)…
- Trial name
- EGG (NCT04241757)
- Testing
- ElectroCardioGram (ECG)
- Where
- France
- Volunteers
- 888 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
COVID-19, Symptoms and Signs
Chlorpheniramine Nasal Spray to Accelerate COVID-19 Clinical Recovery in an Outpatient Setting: ACCROS-III
The goal of this clinical trial is to examine the effectiveness of intranasal-administered Chlorpheniramine Maleate in COVID-19-positive participants as part of early treatment for COVID-19.
- Conditions
- COVID-19, Symptoms and Signs, COVID-19 Pandemic, Coronavirus Disease 2019
- Trial name
- ACCROS-III (NCT05886829)
- Testing
- Chlorpheniramine Maleate 0.4% Nasal Spray
- Where
- Honduras
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Dr. Ferrer BioPharma
Atrial Fibrillation, Quality of Life
The Effect of Walking Exercises in Patients With Atrial Fibrillation
This research will be carried out to determine the effect of walking exercises performed using a behavioral change model on symptom severity and quality of life in patients with Atrial Fibrillation.
- Conditions
- Atrial Fibrillation, Quality of Life, Symptoms and Signs
- Trial name
- NCT05189691
- Testing
- walking exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Necmettin Erbakan University
Chronic Cough
Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043)
The purpose of this study is to evaluate the efficacy and safety of gefapixant in participants with recent onset chronic cough (duration >8 weeks after onset of cough symptoms) for <12 months and a diagnosis of refractory or…
- Trial name
- NCT04193202
- Testing
- Gefapixant
- Where
- 91 sites in United States, Canada and 10 more
- Volunteers
- 419 people
- Sponsor
- Merck Sharp & Dohme LLC
Peripheral Arterial Disease, Intermittent Claudication
Distributed Registry
The purpose of this study is to test if a patient can be directly connected to a quality assurance (QA) database, traditionally known as a registry.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Arteriosclerosis, Atherosclerosis
- Trial name
- NCT03898570
- Testing
- Patient reported outcomes
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Symptom Cluster, Symptoms and Signs
Construction of Symptom Network in Maintenance Hemodialysis Patients
Through a cross-sectional questionnaire survey, a general information questionnaire and Dialysis Frequency, Severity, and Symptom Burden Index were used to investigate the frequency, severity, and degree of symptom distress in…
- Conditions
- Symptom Cluster, Symptoms and Signs, Hemodialysis Complication, Hemodialysis-Associated Pruritus
- Trial name
- NCT05837988
- Where
- China
- Volunteers
- 517 people
- Sponsor
- RenJi Hospital
COPD (Chronic Obstructive Pulmonary Disease)
RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative
The study hypothesis is that symptomatic current and former smokers with spirometric values within the normal range (post-bronchodilator FEV1/FVC≥0.70 and post-BD FVC ≥ 70% predicted will still derive symptomatic benefit from…
- Trial name
- RETHINC (NCT02867761)
- Testing
- Indacaterol/Glycopyrrolate
- Where
- 16 sites in United States
- Volunteers
- 780 people
- Sponsor
- University of Michigan
Antibiotic Resistance, Respiratory Tract Infections
CRP for Respiratory Diagnosis in Kyrgyz Pediatric Practice
Rationale: Overuse of antibiotics globally is leading to increasing rates of antibiotic resistance and may lead to a 'post-antibiotic' era.
- Conditions
- Antibiotic Resistance, Respiratory Tract Infections, Pediatric Infectious Disease, CRP
- Trial name
- COORDINATE (NCT05195866)
- Testing
- CRP POCT (C-reactive protein point of care test)
- Where
- Kyrgyzstan
- Volunteers
- 1,204 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Symptoms and Signs, Symptom Cluster
Patient Reported Symptoms the First Week After Intensive Care Unit Discharge and up to Hospital Discharge
The overall objective of this study is a) to increase knowledge about ICU patient's symptoms and symptom clusters during the first week after ICU discharge, and b) to identify cognitive, psychological, and physical symptoms and…
- Conditions
- Symptoms and Signs, Symptom Cluster, Follow-up Care, Critical Illness
- Trial name
- NCT05266118
- Where
- 2 sites in Norway
- Volunteers
- 177 people
- Sponsor
- Ostfold Hospital Trust
COVID-19, Symptoms and Signs
Chlorpheniramine Nasal Spray to Accelerate COVID-19 Clinical Recovery in an Outpatient Setting: ACCROS-I
The goal of this clinical trial is to examine the effectiveness of intranasal-administered Chlorpheniramine Maleate in COVID-19-positive participants as part of early treatment for COVID-19.
- Conditions
- COVID-19, Symptoms and Signs, COVID-19 Pandemic, Coronavirus Disease 2019
- Trial name
- ACCROS-I (NCT05449405)
- Testing
- Chlorpheniramine Maleate 1% Nasal Spray
- Where
- Honduras
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Dr. Ferrer BioPharma
Respiratory Symptoms, Signs and Symptoms, Digestive
Evaluation of the Composition of Human Milk and Health Outcomes in Children
This study is an evaluation of the composition of human milk and health outcomes in children.
- Conditions
- Respiratory Symptoms, Signs and Symptoms, Digestive, Anemia
- Trial name
- NCT01431482
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Tardive Dyskinesia, Antipsychotic Agents
Randomized Controlled Trial of Pyridoxine for Tardive Dyskinesia
Purpose: Tardive dyskinesia (TD) is a involuntary movement disorder that can occur following long term treatment with antipsychotic medications and for which few treatment options exist.
- Trial name
- NCT03287778
- Testing
- Pyridoxine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill