Clinical trials: Synaptic Plasticity, open to volunteers
Stroke
Efficacy of Music-Based Telerehabilitation After Stroke
The goal of this clinical trial is to learn if a music-based telerehabilitation intervention implemented at home works to treat different kinds of neurological deficits caused by stroke.
- Trial name
- NCT06804304
- Testing
- Music-based telerehabilitation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Teppo Sarkamo
Ischemic Stroke, Stroke Rehabilitaion
Neurological Rehabilitation and Neuroplasticity After Ischemic Stroke
This observational study evaluates the effects of neurological rehabilitation on biological markers associated with neuroplasticity and neurotransmitter profiles in patients after ischemic stroke.
- Trial name
- NCT07899710
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Stroke
Effects Of Functional Action Observation With Auditory Cueing In Stroke Patients
This study aims to determine the effects of functional action observation therapy with and without rhythmic auditory cueing on balance and gait in patients with stroke.
- Trial name
- NCT07428824
- Testing
- Functional Action Observation Therapy, Functional Action Observation Therapy with rhythmic auditory stimulation group
- Where
- 2 sites in Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Spinal Cord Injuries
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of…
- Trial name
- NCT05472584
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Electrophysiology assessment - spinal motoneuron
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Stroke, Hemiparesis
Neuroplasticity After Proprioceptive Rehabiliation
Sequences of muscle tendon vibrations allow to reproduce the sensory feedback during movement like locomotion and kinaesthesia. It is known that such a treatment promotes motor recovery after stroke assuming that it enhances…
- Conditions
- Stroke, Hemiparesis, Traumatic Brain Injury
- Trial name
- VibraLCA (NCT05277519)
- Testing
- Vibrations
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aging
Gait Adaptation Study
This pilot study proposes a clinical trial to target treatment of sensorimotor and cognitive deficits in persons with Multiple Sclerosis (pwMS).
- Trial name
- NCT07660601
- Testing
- Gait Adaptation Training, Basic Physical Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Multiple Sclerosis, Parkinson Disease
Biomarkers of Synaptic Damage in Multiple Sclerosis
A prospective and retrospective cohort study of about five years will be performed on blood and cerebrospinal fluid samples taken for diagnostic reasons from recruited patients within the Neuromed Neurology Unit.
- Conditions
- Multiple Sclerosis, Parkinson Disease, Amyotrophic Lateral Sclerosis, Alzheimer Disease
- Trial name
- NCT03217396
- Testing
- lumbar puncture
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Neuromed IRCCS
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
tDCS, Physical Activity + tDCS
Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults
The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current…
- Conditions
- tDCS, Physical Activity + tDCS, Physical Inactivity + tDCS
- Trial name
- EXOPLASTIC (NCT07438808)
- Testing
- Aerobic Exercise, Physical Inactivity, Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Cortical Excitability, Healthy
Assessing the Effects of Hormones on Noninvasive Transcranial Stimulation
This study is investigating how two types of non-invasive brain stimulation, transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS), affect brain activity, and whether combining them produces…
- Conditions
- Cortical Excitability, Healthy, TMS, Menstrual Cycle
- Trial name
- NCT07635017
- Testing
- Transcranial Electrical Stimulation, Transcranial Magnetic Stimulation, TES + TMS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Attention Deficit Hyperactivity Disorder
Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children
This randomized controlled trial will evaluate the effectiveness of neuroplasticity-targeted supplements on neuroinflammatory markers and ADHD symptoms in children aged 6 to 12 years diagnosed with Attention Deficit Hyperactivity…
- Trial name
- NCT07665658
- Testing
- Inulin, Probiotic, Omega-3 Fatty Acids
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Khyber Medical University Peshawar
Stroke, Ischemic, Sleep Disorder
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients.
- Trial name
- NCT05242393
- Testing
- No intervention is planned
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Neurodevelopmental Disorders
Innovative Methodologies for Neuroplasticity in Developmental Age With the Use of Virtual Reality
Neurodevelopmental disorders, such as Cerebral Palsy (CP), Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), are complex conditions that affect various aspects of children's development.
- Trial name
- NCT07426315
- Testing
- CAREN therapy, Conventional interventions
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Sclerosis
Repetitive Transcranial Magnetic Stimulation (rTMS) in MS Induced Spastic Paraparesis
Study the impact of rTMS on walking ability in people with Multiple Sclerosis (MS) induced spastic paraparesis and moderate walking disability.
- Trial name
- CeV (NCT07159789)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Clinique Neuro-Outaouais
Stroke
Effects of Mirror Therapy and Motor Imagery on Upper Limb Motor Functions in Middle Cerebral Artery Stroke
This study will compare mirror therapy (MT) with motor imagery (MI), each added to routine Bobath-based physical therapy, to assess upper limb motor function and functional independence in patients with subacute middle cerebral…
- Trial name
- NCT07902284
- Testing
- Mirror Therapy, Motor Imagery, Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Major Depressive Disorder, Psychedelic Experiences
Antidepressant Response of DMT Masked With Propofol
The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic…
- Trial name
- DMT4D (NCT06927076)
- Testing
- N,N-Dimethyltryptamine, Propofol, no sedation
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University Hospital, Basel, Switzerland
Mild Cognitive Impairment
Multimodal Investigation of Neural Plasticity
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
- Trial name
- miniSTIM (NCT06453980)
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy, Healthy Adult
Effects of Repetitive Transcranial Magnetic Stimulation on Two Cerebellar Targets
The purpose of this study is to understand how different areas of the cerebellum (a part of the brain) control different functions and how they can be influenced by non-invasive brain stimulation.
- Trial name
- StimCervelet (NCT07561229)
- Testing
- Active rTMS - Lobule VIII, Active rTMS - Crus I/II, Cognitive and Motor Assessment Battery
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Stroke, Stroke Assessment
Non-Invasive Deep Brain Stimulation for Upper Limb Recovery After Stroke (NIMBUS)
NIMBUS is a clinical study evaluating a new, non-invasive brain stimulation treatment to improve arm and hand function in people with long-term effects of stroke.
- Trial name
- NIMBUS (NCT07792811)
- Testing
- Non-invasive transcranial Temporal Interference Stimulation (iTBS-tTIS Striatum), Concurrent Intensive Motor Rehabilitation
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- Friedhelm Hummel
Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Multiple Myeloma
A Cognitive Training Intervention for Improving Cognitive and Neurological Outcomes in Patients Undergoing Treatment for Relapsed or Refractory Multiple Myeloma or B-cell Non-Hodgkin Lymphoma
This clinical trial evaluates whether an online cognitive training intervention (Intervention to enhance Cognitive Augmentation and Neuroplasticity [I-CAN]), delivered before and after treatment with chimeric antigen receptor…
- Conditions
- Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Multiple Myeloma, Refractory B-Cell Non-Hodgkin Lymphoma, Refractory Multiple Myeloma
- Trial name
- NCT07609030
- Testing
- Biospecimen Collection, Cognitive Intervention, Electronic Health Record Review
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University Comprehensive Cancer Center