Clinical trials: Syncope, Vasovagal
Syncope, Syncope, Vasovagal
Assessment of the Mechanism of Non-cardiac Syncope
Identifying the mechanism of non-cardiac syncope is the essential prerequisite for an effective personalized therapy. Aim of this multicentre, prospective, cross-sectional, observational study is to assess effectiveness and…
- Conditions
- Syncope, Syncope, Vasovagal, Orthostatic Hypotension, Syncope, Carotid Sinus
- Trial name
- 2STEPS (NCT05728255)
- Testing
- ABPM plys SCAFB
- Where
- 8 sites in France, Italy and 3 more
- Volunteers
- 330 people
- Sponsor
- Istituto Auxologico Italiano
Syncope, Vasovagal, Neurally-Mediated
Clinical Trial for the Prevention of Vasovagal Syncope
The main question in the study is whether people taking fludrocortisone are less likely to faint than people taking an inactive pill called a placebo. Fludrocortisone is a drug that stimulates the body to retain salt and water.
- Trial name
- NCT00118482
- Testing
- fludrocortisone acetate
- Where
- 14 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- University of Calgary
Syncope
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI).
- Trial name
- NCT00093860
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Syncope, Vasovagal
Preventing Negative Reactions in First Time Blood Donors to Encourage Subsequent Blood Donations
Many individuals experience negative reactions when donating blood, including dizziness, lightheadedness, or fainting. Such reactions may discourage them from donating again.
- Trial name
- NCT00302900
- Testing
- Pre-Donation Water Consumption, Muscle Tensing Exercise During Donation, Muscle Tensing Exercise Prior to Donation
- Where
- 2 sites in United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Ohio University
Neurocardiogenic Syncope, Vasovagal Syncope
Cardioneuroablation for Neurocardiogenic Syncope
The purpose of this study is to evaluate the effectiveness of cardioneuroablation for the treatment of neurocardiogenic syncope (NCS), also known as "vaso-vagal" syncope.
- Trial name
- Ablate-NCS (NCT02009982)
- Testing
- Cardioneuroablation, Biosense Webster Navistar ThermoCool Diagnostic/Ablation Deflectable Tip Catheter
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- David B. De Lurgio
Cardiac Disease, Syncope
Second Study on Cardio-neuromodulation in Humans
Different approaches to cardio-neuroablation (CNA) to treat neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block have been published.
- Conditions
- Cardiac Disease, Syncope, Syncope, Vasovagal, Sick Sinus Syndrome
- Trial name
- CardNMH2 (NCT02954666)
- Testing
- radio-frequency ablation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Imelda Hospital, Bonheiden
Postural Orthostatic Tachycardia Syndrome, Syncope, Vasovagal
Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects
Dysautonomia, primarily defined as postural orthostatic tachycardia syndrome (POTS) can seriously disrupt a child's daily activities. It is most commonly associated with nausea or abdominal pain.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Syncope, Vasovagal, Neurocardiogenic Syncope
- Trial name
- POTS (NCT01617616)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Wake Forest University Health Sciences
Syncope, Vasovagal
Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography
Cardioneuroablation (CNA) is a new method for the treatment of asystolic reflex syncope, however, optimal methods for identification of presumed sites of ganglionated plexi (GP), which are the target for CNA and are located in…
- Trial name
- Roman5 (NCT06472102)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Syncope, Vasovagal
Cardioneuroablation and Ventricular Proarrhythmia
Cardioneuroablation (CNA) is a promising tool to treat patients with asystolic reflex syncope. CNA acts through complete or near complete abolition of vagal nerve chronotropic and dromotropic effects on the heart, resulting in…
- Trial name
- Roman4 (NCT06458140)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Centre of Postgraduate Medical Education
Healthy
Effect of Dietary Salt Supplemantation in Vasovagal Syncope Prophylaxis: A Clinical Trial
Syncope is a syndrome consisting of a relatively short period of temporary and self-limited loss of consciousness caused by transient diminution of blood flow to the brain (most often the result of systemic hypotension).
- Trial name
- NCT00465946
- Testing
- Salt Supplementation
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Syncope, Vasovagal
Influence of Yoga in Patients With Neurocardiogenic Syncope
Syncope is a common problem that many clinicians may encounter in various outpatient settings. Neurocardiogenic syncope (NCS) is a benign condition characterized by a self limited episode of systemic hypotension.
- Trial name
- SYNC - YOGA (NCT01695525)
- Testing
- Yoga
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Dhanunjaya Lakkireddy, MD, FACC
Orthostatic Hypotension, Reflex Syncope
Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)
To characterize the impact of orthostatic hypotension (OH) and Vasovagal syncope on signals measured using a wearable Holter monitor in the clinic and ambulatory setting.
- Trial name
- ARISE (NCT07502599)
- Testing
- Wearable holter monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation
Cardiac Pacemaker, Arrythmia
Aveir DR Real-World Evidence Post-Approval Study
The purpose of this post-approval study is to evaluate the long-term safety of the dual-chamber Aveir DR leadless pacemaker using real-world evidence methods.
- Conditions
- Cardiac Pacemaker, Arrythmia, Bradycardia
- Trial name
- NCT05935007
- Testing
- Aveir DR Leadless Pacemaker System
- Where
- United States
- Volunteers
- 1,805 people
- Sponsor
- Abbott Medical Devices
Syncope, Vasovagal
Wearable Monitor in Patients With Syncope
The main purpose of this study is to assess the reliability of a new patient's self-administered wearable watch-type BP monitor in detecting episodes of hypotensive (pre)syncope.
- Trial name
- Watch-VD (NCT05782647)
- Testing
- HeartGuide cuffless BP monitor
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- Istituto Auxologico Italiano
Syncope, Vasovagal
Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study)
Physiological stimulation therapy effectiveness will be proved with contractility sensor or CLS sensor (Closed Loop Stimulation), in BIOTRONIK CLS pacemakers to prevent from neuromediated syncope.
- Trial name
- SPAIN (NCT01621464)
- Testing
- Pacemaker with Closed Loop Stimulation (CLS sensor)
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Spanish Society of Cardiology
Syncope, Vasovagal, Bradycardia
National Registry of Cardioneuroablation in Recurrent Reflex Syncope
This registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in France. The aim is to evaluate success rates, compare techniques and help institutions set up their own…
- Conditions
- Syncope, Vasovagal, Bradycardia, Heart Arrest
- Trial name
- CANVAS-R (NCT06159764)
- Testing
- Cardioneuroablation
- Where
- 14 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Syncope
Benefit of Dual-chamber Pacing With Closed Loop Stimulation (CLS) in Tilt-induced Cardioinhibitory Reflex Syncope
The purpose of this study is to assess whether the Closed Loop Stimulation (CLS) in addition to the DDD pacing is effective in reducing syncopal recurrences.
- Trial name
- BIOSync CLS (NCT02324920)
- Testing
- DDD-CLS, ODO
- Where
- 24 sites in Canada, France and 4 more
- Volunteers
- 128 people
- Sponsor
- Biotronik SE & Co. KG
Syncope
Effect of Psychotherapy on Quality of Life and Recurrence of Events in Patients With Recurrent Vasovagal Syncope: A Randomized Pilot Study
Recurrent vasovagal syncope although presenting a benign prognosis in terms of survival, is associated with significant impairment of quality of life.
- Trial name
- NCT04252729
- Testing
- Psychotherapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Mauricio Ibrahim Scanavacca
Orthostatic Hypotension, Syncope
The Effect of Water Carbonation on Orthostatic Tolerance
The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers.
- Conditions
- Orthostatic Hypotension, Syncope, Vasovagal Syncope
- Trial name
- NCT05621460
- Testing
- 500mL carbonated water, 500mL still water, 50mL still water
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Vasovagal Syncope, Smoke Inhalation
Relation Between Vasovagal Tendency and Smoking Among University Students
Almost everyone is aware these days is aware about the risk of smoking. Still many people start this habit specially in early life and during college year.
- Trial name
- NCT02949804
- Testing
- Comparison between two groups
- Where
- Jordan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jordan Collaborating Cardiology Group