Clinical trials: Syndrome, Metabolic
Diabetes Mellitus
Long-term Safety of Alogliptin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the long-term safety of alogliptin, once daily (QD), following participation in 1 of 7 controlled studies in patients with type 2 diabetes mellitus.
- Trial name
- NCT00306384
- Testing
- Alogliptin
- Where
- 114 sites in United States, Argentina and 10 more
- Volunteers
- 3,323 people
- Sponsor
- Takeda
Metabolic Syndrome
Resistance Training and Metabolic Syndrome
Metabolic syndrome (MetS) is a multicomponent disorder closely linked to low grade inflammation, and cardiovascular disease (CVD).
- Trial name
- NCT02918448
- Testing
- Training group
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Celiac Disease
Latiglutenase as a Treatment for Celiac Disease
Single Center, Randomized, Double-Blind, Placebo Controlled, Gluten Challenge Trial in Patients with Well-Controlled Celiac Disease
- Trial name
- NCT03585478
- Testing
- Latiglutenase
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Immunogenics, LLC
Disability Physical
Geriatric Syndrome in Nursing Home Residents
Disability in daily living activities (ADL) is a typical issue among nursing care residents. The goal of this study was to look at the geriatric syndromes that cause incapacity in nursing home residents.
- Trial name
- NCT06082908
- Testing
- Diagnostic test
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Giresun University
Disorder of Sex Development, Intersex Conditions
Decision Support for Parents Receiving Information About Child's Rare Disease
The birth of a child with a disorder of sex development (DSD) is stressful for parents and members of the healthcare team. The "right" decisions about gender assignment (is it a boy? a girl?) and the best course of action (e.g.…
- Conditions
- Disorder of Sex Development, Intersex Conditions, Congenital Adrenal Hyperplasia, Hypospadias
- Trial name
- DSD DST (NCT01875640)
- Where
- 4 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Polycystic Ovary Syndrome (PCOS), Insulin Resistance Syndrome
Evaluation of MG53 (TRIM72) Levels in Women With Polycystic Ovary Syndrome: An Observational Study
Purpose of the Study: This study is being conducted to examine a protein called MG53 (also known as TRIM72) in women with polycystic ovary syndrome (PCOS).
- Trial name
- PCOSMG53 (NCT07094776)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Havva Betül Bacak
Functional Gastrointestinal Disorders, Lactose Intolerance
Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders
Background: The association of fructose and lactose intolerance and malabsorption with the symptoms of different functional gastrointestinal disorders (FGID) is unclear.
- Conditions
- Functional Gastrointestinal Disorders, Lactose Intolerance, Fructose Intolerance
- Trial name
- NCT02085889
- Testing
- no intervention: observational study
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- Brain-Gut Research Group
Celiac Disease
Safety and Systemic Exposure Study of BL-7010 in Well-Controlled Celiac Patients.
The purpose of this study is to evaluate the safety of different amounts of BL-7010 in single oral administration and in repeated oral administration to well-controlled celiac patients.
- Trial name
- NCT01990885
- Testing
- BL-7010
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- BioLineRx, Ltd.
Celiac Disease
Prevalence of Renal Disease in Children With Celiac Disease
To assess the prevalence of renal disease in a pediatric population of patients with celiac disease by looking for the presence of hematuria and/or proteinuria.
- Trial name
- COELIGAN (NCT05049876)
- Testing
- urine sample taken during consultations
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity
Lipophilic Organic Polluants and Morbid Obesity
1. To study the kinetics of release after bariatric surgery of selected polluants stored in adipose tissue, looking for clinical and/or predictive factors 2.
- Trial name
- POLOB (NCT01969968)
- Testing
- Lipophilic Organic Polluants dosage
- Where
- France
- Volunteers
- 232 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Celiac Disease
Virtual Chromoendoscopy With Magnification in Coeliac Disease.
High-definition white light endoscopy (HD-WLE) does not usually allow the visualization of duodenal villous patterns and may be inaccurate for assessing coeliac disease (CD).
- Trial name
- NCT05103150
- Testing
- High-definition white light endoscopy (HD-WLE), HD-WLE plus I-Scan optical enhancement (OE) virtual chromoendoscopy with High-definition optical magnification (HD-OM)
- Where
- Ecuador
- Volunteers
- 40 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Upper Extremity Impairments, Cerebral Palsy (CP)
Obi Medical Robot: Evaluating Effectiveness Related to Usability
This mixed-methods usability study evaluates the effectiveness of the Obi Gen 3 robotic feeding device in meeting user needs among providers, caregivers, and patients.
- Conditions
- Upper Extremity Impairments, Cerebral Palsy (CP), ALS - Amyotrophic Lateral Sclerosis, Rett Syndrome
- Trial name
- NCT07151950
- Testing
- One-week trial of Obi Medical device, which provides robotic assistance with feeding to persons with upper extremity impairments who are unable to self-feed in the traditional manner using utensils
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Desin LLC
Thrombocytopenia, Metachromatic Leukodystrophy
Stem Cell Transplantation (SCT) for Genetic Diseases
OBJECTIVES: I. Ascertain whether stem cell transplantation (SCT) is an effective method by which missing or dysfunctional enzymes can be replaced in patients with various inborn errors of metabolism. II.
- Conditions
- Thrombocytopenia, Metachromatic Leukodystrophy, Fanconi's Anemia, Thalassemia Major
- Trial name
- NCT00004378
- Testing
- Stem Cell Transplantation
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Primary Tauopathies, Corticobasal Degeneration Syndrome
BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different…
- Conditions
- Primary Tauopathies, Corticobasal Degeneration Syndrome, Frontotemporal Lobar Degeneration With Tau Inclusions, MAPT Mutation Carriers, Symptomatic
- Trial name
- TauBasket (NCT03658135)
- Testing
- BIIB092
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Steatorrhea
Creon in HIV Patients With Steatorrhea
The study investigates the effect of pancreatic enzymes on steatorrhea in HIV patients.
- Trial name
- NCT00623025
- Testing
- Creon 25000
- Where
- 2 sites in Romania
- Volunteers
- 34 people
- Sponsor
- Abbott
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Diabetes Mellitus
Statins in Patients With Type 2 Diabetes Mellitus and Previous History of Acute Coronary Syndrome
The purpose of this study was to compare the efficacy and safety of high dose atorvastatin (40 mg) versus high dose rosuvastatin (20 mg) in Egyptian type II diabetic patients with previous acute coronary syndrome history.
- Trial name
- NCT05306990
- Testing
- Atorvastatin 40 Mg Oral Tablet, Rosuvastatin 20 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Helwan University
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Non-alcoholic Fatty Liver Disease, Type 2 Diabetes
Role of New Adipokines and Hepatokines in Prediction of Patients With Metabolic Syndrome or NAFLD
To investigate the predictive roles of adipokines and hepatokines to detect non-alcoholic fatty liver disease (NAFLD), diabetes, or dyslipidmia.
- Conditions
- Non-alcoholic Fatty Liver Disease, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT02285218
- Testing
- serum blood sampling
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Sleep Apnea, Glucose Metabolism Disorders
Obstructive Sleep Apnea and Glucose Metabolism
Many adults who are overweight have obstructive sleep apnea (OSA) which disrupts sleep and makes it difficult to breath during the night. OSA increases the risk for a person to become insulin resistant and diabetic.
- Trial name
- OSAGM (NCT03408613)
- Testing
- Positive Airway Pressure, Supplemental Oxygen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Prediabetes
Blood Sugar Take Care and Glucose Metabolism
This prospective international clinical trial is a two-arm, double-blind, randomized, placebo-controlled, parallel-group, multicenter study. 112 prediabetic subjects will be randomized to Blood Sugar Take Care or placebo.
- Trial name
- NCT01554020
- Testing
- Blood Sugar Take Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NewChapter, Inc.