Clinical trials: Syndrome, Metabolic
Obstructive Sleep Apnea, Obesity
Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese
This study evaluates the effectiveness of intraoral appliance in the treatment of obstructive sleep Apnea Syndrome in class III obese in comparison to an adjustable silicone appliance.
- Trial name
- NCT03517150
- Testing
- mandibular advancement device
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Cancer, Cardiac Disease
Cardio-Oncology Registry
Cardio-oncology is an emerging field. Most of the data available have been issued from either retrospective analysis, industry data or pharmacovigilance data. These data sources include a number of bias.
- Conditions
- Cancer, Cardiac Disease, Metabolic Syndrome, Arrhythmia
- Trial name
- CONFUCIUS (NCT04407780)
- Testing
- No interventions are planned
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- European Georges Pompidou Hospital
Celiac Disease
Safety and Efficacy of Varying Methods of ALV003 Administration for the Treatment of Celiac Disease
A phase 2a study to evaluate the safety and efficacy of ALV003 to treat celiac disease.
- Trial name
- NCT01255696
- Testing
- ALV003
- Where
- 3 sites in Finland
- Volunteers
- 61 people
- Sponsor
- Alvine Pharmaceuticals Inc.
Obesity, Metabolic Syndrome
Strawberry Consumption in Overweight and Obese Individuals
Our proposal represents an integrated approach to determining the cardiovascular and metabolic effects of strawberry consumption in adults who have high risk for cardiometabolic disease.
- Trial name
- NCT04094103
- Testing
- Active strawberry powder, Mixed strawberry powder
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Carl Ade, M.S., Ph.D.
Insulin Resistance, Obesity
Surgical Removal of Visceral Fat Tissue (Omentectomy) Associated to Bariatric Surgery: Effects on Insulin Sensitivity
The intraabdominal fat is associated with insulin resistance, a condition that is in the basis of diabetes, metabolic syndrome and some cardiovascular diseases.
- Conditions
- Insulin Resistance, Obesity, Metabolic Syndrome X
- Trial name
- NCT00545805
- Testing
- Roux-en-Y Gastric Bypass plus total omentectomy, Roux-en-Y Gastric Bypass
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil
Refeeding Syndrome, Malnutrition
Gastrointestinal Hormones and Metabolomic Profiling Following Mixed-Meal Tolerance Tests in Patients at Risk of Refeeding Syndrome
Introduction: Refeeding syndrome (RS) is a life-threatening metabolic complication of nutritional support. Prolonged fasting, frequently observed in malnourished patients referred for percutaneous endoscopic gastrostomy (PEG)…
- Trial name
- NCT07674589
- Where
- Portugal
- Volunteers
- 15 people
- Sponsor
- Hospital Garcia de Orta
Type 2 Diabetes Mellitus
Paleolithic Diets vs T2D and Improvements in the Metabolic Syndrome
This study proposes to evaluate the physiological effects of eating Paleolithic type diet ("hunter-gatherer's diet") on Type 2 diabetic patients.
- Trial name
- NCT00548782
- Testing
- Paleolithic diet, ADA ( American Diabetes Association) recommended diet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obstructive Sleep Apnea, Diabetes Mellitus
Obstructive Sleep Apnea and Diabetes Mellitus
The investigators hypothesize that obstructive sleep apnea (OSA) contributes to impaired glucose homeostasis and associated vasculopathy, and nCPAP treatment of OSA should improve glycemic control and vascular function in OSA…
- Trial name
- NCT00876980
- Testing
- nasal Continuous Positive Airway Pressure
- Where
- Hong Kong
- Volunteers
- 64 people
- Sponsor
- The University of Hong Kong
Mucopolysaccharidosis IVA, Morquio A Syndrome
Safety and Exercise Study of Two Doses of BMN 110 for Morquio A Syndrome
The primary objective of this study was to evaluate the safety of a 2.0 mg/kg/week and a 4.0 mg/kg/week of BMN 110 in patients with Morquio A syndrome for up to 196 weeks.
- Conditions
- Mucopolysaccharidosis IVA, Morquio A Syndrome, MPS IVA
- Trial name
- NCT01609062
- Testing
- BMN 110
- Where
- 11 sites in United States, Canada and 2 more
- Volunteers
- 25 people
- Sponsor
- BioMarin Pharmaceutical
Obesity
Interdisciplinary Intervention in Patients With Obesity and Other Metabolic Diseases
The aim of the research study will be assess the effectiveness of a long-term interdisciplinary lifestyle in many aspects including food intake, psychological symptoms, physical activity habits, energy expenditure, body…
- Trial name
- NCT02573688
- Testing
- Interdisciplinary Therapy
- Where
- Brazil
- Volunteers
- 87 people
- Sponsor
- Federal University of São Paulo
Lipid Disorder, Dyslipidemias
Causal Mechanisms in Adolescent Arterial Stiffness
Hardening of the blood vessels, called arterial stiffness, is a risk factor for future heart disease and its causes are unclear.
- Conditions
- Lipid Disorder, Dyslipidemias, Aortic Stiffness, Insulin Resistance Syndrome
- Trial name
- NCT04128969
- Testing
- CS+, CS-
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Baylor College of Medicine
Metabolic Syndrome
Safety, Tolerability and Pharmacokinetic Study of MB12066 in Healthy Male Volunteers
The purpose of this study is to investigate the safety and tolerability of MB12066 after multiple dose and to investigate the pharmacokinetic characteristics of MB12066 after multiple dose.
- Trial name
- NCT02338856
- Testing
- MB12066 200mg
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Obesity Hypoventilation Syndrome (OHS)
Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation Syndrome
Introduction: Obesity Hypoventilation Syndrome (OHS) is defined as the coexistence of obesity (BMI ≥ 30 kg/m²), daytime hypercapnia (PaCO₂ > 45 mmHg) in the absence of other causes of hypoventilation, and sleep-disordered…
- Trial name
- NCT07147153
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bezmialem Vakif University
Lead Poisoning, Neurotoxicity
Effects of Lead Exposure on Ferroptosis Pathway
The aim of this study was to investigate the effects of chronic lead exposure on iron metabolism and the Nrf2-dependent ferroptosis pathway in lead acid battery factory workers
- Trial name
- NCT05950386
- Testing
- Lead exposure
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northern Jiangsu People's Hospital
Spinal Cord Injuries, Obesity
Spinal Cord Injury Model Systems (SCIMS) - Education Module
The purpose of this study is to find out if receiving education regarding increased risks of cardiometabolic disease helps subjects understand these risks and how these risks participants' health.
- Conditions
- Spinal Cord Injuries, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT06003686
- Testing
- PVA Consumer Guide, WebMD
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Miami
Demyelinating Diseases, Demyelination; Corpus Callosum
Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair Therapy
The clinical trial is intended to assess for clinical evidence of Clemastine Fumarate as a myelin repair therapy in patients with acute inflammatory injury-causing demyelination as measured by multi-parametric MRI assessments.
- Conditions
- Demyelinating Diseases, Demyelination; Corpus Callosum, Multiple Sclerosis Brain Lesion, Multiple Sclerosis Acute and Progressive
- Trial name
- ReINFORCE (NCT06065670)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Obstructive Sleep Apnea, Diabetes Mellitus
Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea
The investigators plan to recruit 140 patients (35 subjects in each group) over a period of 18 months in a prospective study of matched/paired case-control subjects across the four groups to measure the 5-year risk of developing…
- Trial name
- OSA & DM (NCT01447251)
- Testing
- PreDx Diabetes Risk Score
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Sleep Apnea, Diabetes
Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy
This is a randomized control trial in people with diabetes and obstructive sleep apnea who will be randomly assigned for 3 months to PAP therapy along with healthy lifestyle and sleep education or healthy lifestyle and sleep…
- Trial name
- HYPNOS (NCT02454153)
- Testing
- REMStar Positive Airway Pressure, LifeStyle Counseling
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Johns Hopkins University
Celiac Disease
Probiotic Blend for Celiac Disease
The objective of the study is to develop a probiotic product (B. longum CCT 1934; B. lactis CCT 7858; L. rhamnosus CCT 7863; S. thermophilus ATCC 19258) to reduce the symptoms caused by celiac disease and concomitantly improve…
- Trial name
- NCT05646823
- Testing
- Probiotic blend
- Where
- Brazil
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Hematologic Disorders, Hemoglobinopathies
Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)
This is a treatment guideline for a second or greater allogeneic hematopoietic stem cell transplant (HSCT) using a reduced intensity conditioning (RIC) in patients with non-malignant or malignant diseases.
- Conditions
- Hematologic Disorders, Hemoglobinopathies, Immunodeficiencies
- Trial name
- NCT01666080
- Testing
- Busulfan, Fludarabine, Total body irradiation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Masonic Cancer Center, University of Minnesota