Clinical trials: Synthetic Mesh
Stress Urinary Incontinence
Autologous Versus Synthetic Versus Biological Sling for Trans-obturator Correction of Urinary Stress Incontinence
The treatment of urinary stress incontinence with trans-obturator approach, know as transobturatory tape (TOT), is a largely used sling-adopting procedures.
- Trial name
- NCT00744198
- Testing
- Autologous transobturator tape procedure, Synthetic transobturator tape procedure, Biological transobturator tape procedure
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- University Magna Graecia
Parastomal Hernia
Stoma Hernia Intraperitoneal Full-Thickness Skin
This is a prospective randomized study to compare surgical methods for the repair of parastomal hernia.
- Trial name
- SHIFT (NCT03667287)
- Testing
- Repair of parastomal hernia
- Where
- 2 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Umeå University
Apical Prolapse, Sacrocolpopexy
Evaluation of the Use of Synthetic Glue for Mesh Fixation in Laparoscopic Sacrocolpopexy
The aim of the study is to evaluate the effect of cyanoacrylate adhesive in laparoscopic sacrocolpopexy, which is the gold standard treatment for apical prolapse.
- Conditions
- Apical Prolapse, Sacrocolpopexy, Glue Fixation
- Trial name
- LSCGlue (NCT06872983)
- Testing
- cyanoacrylate tissue adhesive beside sutures, Suture
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Brno University Hospital
Breast Cancer
Pre-pectoral Breast Reconstruction PART 1
The rationale for present trial conception and design moves forward from the assumption that a subcutaneous, pre-pectoral reconstruction by means of soft tissue replacement devices is feasible, safe and giving rewarding results…
- Trial name
- PreBRec (NCT02830685)
- Testing
- DTI with Acellular Dermal Matrix (CELLIS® Breast), DTI with Titanium Coated Polypropylene Mesh (TiLOOOP® Bra)
- Where
- United Kingdom
- Volunteers
- 131 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Ventral Hernia
Biologic Mesh Versus Synthetic Mesh in Repair of Ventral Hernias
This study will compare the safety, efficacy and cost effectiveness of a permanent synthetic mesh versus a biologic prosthesis for the repair of ventral hernias in the setting of clean-contaminated (Class 2) or contaminated…
- Trial name
- NCT02451176
- Testing
- Davol Bard Soft Mesh synthetic, LifeCell Strattice Reconstructive Tissue Biologic
- Where
- 4 sites in United States
- Volunteers
- 253 people
- Sponsor
- Michael Rosen
Primary and Secondary Ventral Hernia
Primary and Secondary Ventral Hernia Repair Using Long-term Resorbable Versus Non-resorbable Large Pore Synthetic Mesh.
Since abdominal wall hernia repair is currently performed with the use of a mesh, side effects associated with the mesh are frequently reported during long term follow-up.
- Trial name
- TIGR (NCT01622725)
- Testing
- Placing the resorbable mesh, Non-resorbable synthetic mesh.
- Where
- 6 sites in Belgium, Denmark and 3 more
- Volunteers
- 95 people
- Sponsor
- University Hospital, Ghent
Abdominal Wall Defect, Abdominal Wall Hernia
Abdominal Wall Reconstruction With PVDF Mesh in the Setting of Active Infection
The use of synthetic mesh to repair infected defects of the abdominal wall remains controversial. This study aimed to evaluate the short-term outcomes of using PVDF mesh to treat infected abdominal wall defects in the elective…
- Conditions
- Abdominal Wall Defect, Abdominal Wall Hernia, Abdominal Wall Infection, Abdominal Wall Fistula
- Trial name
- NCT05061264
- Testing
- Abdominal wall reconstruction
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- University of Sao Paulo General Hospital
Patients Undergoing Open Hernia Repair, Patients Undergoing Ventral or Inguinal Hernia Repair
Reducing Mesh Infections in Open Hernia Repairs
Soaking meshes in a vancomycin solution just prior to their use in open hernia repairs will decrease rates of mesh infection
- Trial name
- NCT01860469
- Testing
- vancomycin-soaked mesh, plain mesh
- Where
- Canada
- Sponsor
- University of Saskatchewan
Hernia, Ventral, Hernia Incisional
Short Term Outcomes of Heavy-weight Versus Medium-weight Synthetic Mesh
This study compares short term outcomes of patients undergoing a hernia repair with heavy weight mesh vs medium weight mesh in clean-contaminated and contaminated cases.
- Trial name
- NCT06409091
- Testing
- Medium weight or Heavy weight mesh
- Where
- United States
- Volunteers
- 1,496 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Breast Cancer
Pre-pectoral Breast Reconstruction PART 2
The rationale for present trial conception and design moves forward from the assumption that a subcutaneous, pre-pectoral reconstruction by means of soft tissue replacement devices is feasible, safe and giving rewarding results…
- Trial name
- PreBRec (NCT02831426)
- Testing
- Two-stage with Acellular Dermal Matrix (CELLIS® Breast), Two-stage with Titanium Coated Polypropylene Mesh (TiLOOOP® Bra)
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Open Abdomen, Incisional Hernia
Synthetic Mesh for Prevention of HernIa After opEn Abdomen cLosure stuDy
The aim of this clinical trial is to evaluate whether placement of a synthetic prophylactic onlay mesh during definitive fascial closure can reduce the incidence of incisional hernia in adult patients managed with an open abdomen…
- Conditions
- Open Abdomen, Incisional Hernia, Definitive Fascial Closure, Emergency Abdominal Surgery
- Trial name
- SHIELD (NCT07835334)
- Testing
- Definitive Fascial Closure Without Prophylactic Mesh, Prophylactic Onlay Mesh Placement
- Volunteers
- 30 people
- Sponsor
- Hospital San Juan de Dios Tenerife
Ventral Hernia, Postoperative Pain
Full-thickness Skin vs. Synthetic Mesh in the Repair of Large Incisional Hernia
This is a prospective randomized study to compare surgical methods for the repair of large abdominal hernia.
- Trial name
- NCT01413412
- Testing
- Ventral hernia repair using full thickness skin graft, Ventral hernia repair using mesh
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Abdominal Wall Defect, Abdominal Wall Infection
The Use of Synthetic Mesh in Contaminated and Infected Abdominal Wall Repairs. A Long-term Prospective Clinical Trial
Background: Abdominal wall reconstruction in patients presenting with enteric fistulas and mesh infection is challenging. There is a consensus that synthetic mesh must be avoided in infected operations.
- Conditions
- Abdominal Wall Defect, Abdominal Wall Infection, Abdominal Wall Fistula, Infection
- Trial name
- NCT03702153
- Testing
- Abdominal wall reconstruction
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Ventral Hernia
The Use of Biologic Mesh vs Bioabsorbable Mesh During Ventral Hernia Repair in At-risk Patients
This study evaluates the outcomes of patients who have been treated with Strattice or Gore Bio-A mesh for the repair of complicated abdominal wall hernias.
- Trial name
- NCT01794338
- Testing
- Strattice Arm, Bio-A Arm
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Pelvic Organ Prolapse
Composite Outcomes of Mesh vs Suture Techniques for Prolapse Repair: A Randomized Controlled Multicentre Trial
This is a Canadian, multi-centre, double-blind randomized controlled trial of an innovative vaginal surgery technique for correction of pelvic organ prolapse (POP) in women.
- Trial name
- COMET (NCT02965313)
- Testing
- SSLS Procedure, BSSVF-M Procedure
- Where
- Canada
- Volunteers
- 358 people
- Sponsor
- University of British Columbia
Colorectal Disorders, Prolapse
Biological OviTex Versus Synthetic Graft in Robotic Prolapse Surgery
This prospective study aims to assess the efficacy of the OviTex 1S permanent mesh in pelvic floor surgery in comparison with the current standard polypropylene mesh.
- Conditions
- Colorectal Disorders, Prolapse, Prolapse Rectal, Prolapse Genital
- Trial name
- ProTex (NCT06430931)
- Testing
- Minimal invasive abdominal prolapse surgery using Polypropylene mesh, Minimal invasive abdominal prolapse surgery using OviTex 1S permanent mesh
- Where
- Netherlands
- Volunteers
- 184 people
- Sponsor
- Meander Medical Center
Inguinal Hernia
Mesh Fixation With a Synthetic Glue in Primary Inguinal Hernia Repair
Prospective observational study with mesh fixation using FDA approved synthetic glue,glubran 2 and standard mesh fixation with stiches in primary inguinal hernia repair surgery.
- Trial name
- NCT02507830
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rambam Health Care Campus
Hiatal Hernia
Biologic Versus Synthetic Mesh for Treatment of Paraesophageal Hernia
The investigators propose a randomized, single blinded controlled trial to compare the use of synthetic versus biologic mesh in hiatal hernia repair, two currently accepted standard of care surgical modalities.
- Trial name
- NCT02242526
- Testing
- Parietex™ Composite Hiatal Mesh, North Haven, CT, Biodesign™ Surgisis® Graft, Cook Medical, Bloomington
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Large Hiatal Hernia
Onlay Synthetic Bioabsorbable Mesh Herniorrhaphy Versus Herniorrhaphy Only in the Primary Treatment of Large Hiatal Hernia
The large hiatal hernia (LHH) now represents approximately 50% of laparoscopic antireflux surgical practice. In a non-comparative retrospective study of 399 patients operated for LHH with onlay patch of a bioprosthetic absorbable…
- Trial name
- HIATUS (NCT05867225)
- Testing
- Laparoscopic hiatal hernia repair
- Where
- 26 sites in France
- Volunteers
- 256 people
- Sponsor
- University Hospital, Bordeaux