Clinical trials: Synucleinopathy
Parkinson's Disease (PD)
STN-tTIS With Different Intervention Intervals Versus Standard Medical Treatment for Parkinson's Disease
The goal of this clinical trial is to compare the efficacy and safety of different Intervention Intervals of subthalamic nucleus-targeted transcranial temporal interference stimulation (STN-tTIS) in patients with Parkinson…
- Trial name
- NCT07774312
- Testing
- STN-tTIS Once Weekly, STN-tTIS Twice Weekly, STN-tTIS Five Times Weekly
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
Virtual Reality Can be Used to Improve Balance Reducing Dynamic Falls in Those With Parkinson's Disease
This study aims to explore the use of full immersion virtual reality technology on improving balance in those with Parkinson's Disease.
- Trial name
- NCT03406728
- Testing
- PDSAFEX, CONTROL, VIRTUAL REALITY
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Parkinson Disease (PD)
Outlining Biological Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease Patients.
The aim of the study is to characterize the neuroinflammatory effects of subthalamic deep brain stimulation in patients with Parkinson's disease, by analyzing changes in blood neuroinflammatory and neurodegenerative biomarkers…
- Trial name
- BRAIN-DBS-GAIN (NCT07673783)
- Testing
- Deep brain stimulation surgery
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parkinson Disease
Validity of the 6-Minute Pegboard and Ring Test in Parkinson's Patients
Tests used to assess upper extremity endurance in Parkinson\'s patients are limited. This study aimed to investigate whether the 6-Minute Pegboard and Ring Test (6-MPRT), which has been validated in many respiratory disease…
- Trial name
- NCT06482502
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Emre Şenocak
Social Perception in Parkinson's Disease
Brain Mechanisms of Social Perception in Parkinson's Disease
Social cognition is a complex process that enables humans to interpret social information and behave appropriately in a social environment.
- Trial name
- Park Social (NCT06884722)
- Testing
- Behavioral task of social perception (stage 1), Functional magnetic resonance imaging: 3 Tesla magnetic resonance imaging (stage 2), Neurological and neuropsychological assessments
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease, COVID
Evaluation of the Containment Impact Linked to the Covid-19 Pandemic in a Population of Parkinson Patients
The consequences of COVID-19 in these already fragile patients should be evaluated. It will be important to appreciate the confinement consequences imposed on the patient on the course and impact of the disease.
- Trial name
- ERCO-Park (NCT04466839)
- Testing
- Questionnaire and interview
- Where
- 8 sites in France
- Volunteers
- 411 people
- Sponsor
- University Hospital, Toulouse
Parkinson's Disease
MENTAL PRACTICE IN MOTOR LEARNING OF BRUSHING AND PARKINSON DISEASE
Parkinson's disease (PD) is characterized by dopaminergic neurons degeneration of the substantia nigra, in the midbrain, resulting in the presence of motor disorders, such as tremor, rigidity, bradykinesia, and postural…
- Trial name
- NCT02738528
- Testing
- Mental practice and brushing guidance in patients with Parkinson Disease
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Parkinson Disease
Validity and Reliability of VO2-max Measurements in Persons With Parkinson's Disease
Each participant would complete four test days and each test day is separated by 7-10 days. At each test day the participants would complete a graded maximal exercise test (VO2max-test), a chair rise (Linear encoder) as well as…
- Trial name
- NCT05127031
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Parkinson Disease
Stereotactic Intracerebral Injection of IPSC-DAPs in Patients with Parkinson's Disease
Parkinson's disease is a progressive neurodegenerative disorder characterized by high morbidity due to the limited regenerative capacity of dopaminergic neurons in the brain.
- Trial name
- NCT06821529
- Testing
- ICA07 therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- iCamuno Biotherapeutics Ltd.
Parkinson Disease
Treatment of Balance Disorders in Parkinson's Patients Using SpotOn Balance Glasses
An open-label study to evaluate the effect of SpotOn balance glasses in non-demented Parkinson's patients with balance disorders.
- Trial name
- NCT03942172
- Testing
- SpotOn balance glasses
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- SpotOn Therapeutics Ltd.
Parkinson Disease (PD)
Steps Against the Burden of Parkinson's Disease
Parkinson's Disease Treadmill Training RCT Summary Parkinson's disease (PD) affects over 10 million people globally. Despite optimal pharmacological treatment, approximately 70% of individuals experience unstable gait and falls…
- Trial name
- StepuP (NCT07057219)
- Testing
- Exercise
- Where
- Australia
- Volunteers
- 42 people
- Sponsor
- The University of New South Wales
Parkinson Disease
Effects of Lactobacillus Plantarum PS128 on the Parkinsonian Symptoms in Parkinson's Disease.
This RCT study is designed to examine the extent to which L. plantarum PS128 can improve symptoms in PD patients. L. plantarum PS128 is a psychobiotic that regulates the level of dopamine in specific brain regions.
- Trial name
- NCT04722211
- Testing
- PS128
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Professor Lu Neurological Clinic
Parkinson's Disease
The HIIT-Home4Parkinson's Study
This project aims to investigate the practicality and utility of home-based high-intensity interval training (HIIT) by undertaking a previously developed, novel home-based HIIT intervention for people with Parkinson's (PwP).
- Trial name
- HH4P (NCT05485428)
- Testing
- High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Plymouth
Parkinson's Disease
Exercise for People With Parkinson's Disease
This randomized, controlled exercise intervention with three groups compares two exercise approaches to standard of care. Supervised interventions are administered for four months, with emphasis on patients adopting exercise…
- Trial name
- NCT01257945
- Testing
- Aerobic Exercise, Flexibility and Function exercise program, Home exercise program
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease
The purpose of the study is to demonstrate the safety and effectiveness of adaptive DBS (aDBS) for Parkinson's disease.
- Trial name
- ADAPT-PD (NCT04547712)
- Testing
- Adaptive DBS
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 85 people
- Sponsor
- MedtronicNeuro
Parkinson Disease
Brain Stimulation for Patients With Parkinson Disease
The aim of this crossover study is to investigate the efficacy of non-invasive brain stimulation (transcranial pulse stimulation; TPS) in adults with Parkinson Disease (PD).
- Trial name
- NCT04333511
- Testing
- TPS (NEUROLITH)
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Storz Medical AG
Parkinson Disease
Effect of Doxycycline in Levodopa Treated Parkinson's Disease Patients
This study is a Randomized, Double-Blind, Placebo-Controlled Trial. The objective of the study is to assess the effect of doxycycline in levodopa treated Parkinson's disease patients regarding motor performance and cognitive…
- Trial name
- NCT05492019
- Testing
- Doxycycline
- Where
- Bangladesh
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Early-Stage Parkinson's Disease
An Open-Label Extension Trial to Assess the Safety of Long-Term Treatment of Rotigotine in Early-Stage Parkinson's Disease.
The objective of this open-label extension is to assess the safety and tolerability of long-term treatment of the rotigotine patch in subjects with early-stage idiopathic Parkinson's disease.
- Trial name
- SP512OL (NCT00594165)
- Testing
- Rotigotine
- Where
- 42 sites in United States, Canada
- Volunteers
- 217 people
- Sponsor
- UCB Pharma
Parkinson Disease
Safety and Efficacy of Adaptive DBS Vs Conventional DBS in Patients With Parkinson's Disease
This is an exploratory study to preliminary assess safety and efficacy of an adaptive Deep Brain Stimulation (DBS) closed-loop method in patients with PD.
- Trial name
- NCT03422757
- Testing
- adaptive Deep Brain Stimulation, conventional Deep Brain Stimulation
- Where
- 4 sites in Italy
- Volunteers
- 6 people
- Sponsor
- Newronika
Parkinson Disease, Deep Brain Stimulation
Burst-Type Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
This is a study to evaluate Deep brain stimulation (DBS) burst-type electrical stimulation programming verses standard DBS programming.
- Trial name
- BURST (NCT05753449)
- Testing
- Baseline (or standard of care) DBS programming, Burst-type DBS electrical stimulation programming
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)