Clinical trials: System Fragmentation
Anesthesia, Surgery
General Versus Regional Anesthesia and Postoperative Sleep Quality
Major surgery can lead to postoperative disturbances in sleep patterns with subjective deterioration of sleep quality according to patients' reports as well as objective alterations of sleep architecture, as recorded by…
- Conditions
- Anesthesia, Surgery, Sleep Disturbance, Sleep Disorder
- Trial name
- AnesthSleep (NCT03843645)
- Testing
- general anesthesia, regional anesthesia
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Colonic Diverticuar Disease, Defecatory Functions
Effects of Inferior Mesenteric Artery Preservation in Laparoscopic Colorectal Resection for Diverticular Disease.
This is a prospective randomized study aimed to verifying the short and long-term results of inferior mesenteric artery preservation following colorectal resection for diverticular disease
- Conditions
- Colonic Diverticuar Disease, Defecatory Functions, Fecal Incontinence, Constipation
- Trial name
- EIMAP (NCT06506552)
- Testing
- IMA preserving, IMA sectioning
- Volunteers
- 300 people
- Sponsor
- University of Roma La Sapienza
Diabetic Foot
Autologous Micro-fragmented Adipose Tissue in the Treatment of Minor Amputations of Diabetic Foot
This is a randomized controlled monocentric study on 114 diabetic patients with the aim of evaluating the efficacy of the lipofilling with Lipogems® system in diabetic patients that are candidates for a minor amputation in the…
- Trial name
- NCT03276312
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- University of Modena and Reggio Emilia
The Role of the LC-NA System in Sleep Regulation
The Role of the LC-NA System in Experimental Sleep Fragmentation
Sleep-wake regulation affects every person's life, yet the molecular mechanisms underlying these processes remain poorly understood.
- Trial name
- DMTN_FragSleep (NCT07167316)
- Testing
- DMTN, Auditory Stimulation, Placbo
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hans-Peter Landolt
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Ovarian Failure, Premature Ovarian Failure
Ovarian Fragmentation Study (Crespo Medical Team)
This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation.
- Conditions
- Ovarian Failure, Premature Ovarian Failure, IVF
- Trial name
- NCT04306185
- Testing
- OVARIAN FRAGMENTATION
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Equipo Juana Crespo
Fecal Incontinence
Fat Grafting Technique for Fecal Incontinence
Fecal Incontinence affects an estimated 2-20% of the general population, and up to 50% of the elderly and institutionalized population.
- Trial name
- NCT03882632
- Testing
- Fat Grafting for Fecal Incontinence
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Melanie Salerno, RN
Circadian Dysregulation, Sleep Fragmentation
Compromised Sleep and Circadian Health After Critical Illness: From Diagnosis to Prediction (CHRONOCRIT)
The intensive care unit (ICU) is recognizably detrimental to sleep and circadian health, and critical survivors frequently report the presence of alterations in this regard after hospital discharge.
- Trial name
- CHRONOCRIT (NCT05995132)
- Where
- Spain
- Volunteers
- 271 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Sleep Fragmentation, Behavioural and Psychiatric Symptoms of Dementia
Therapy Light Rooms for Improved Sleep in Dementia Patients
This intervention study will investigate the effect of therapy light rooms on sleep, circadian rhythms, mood, behavioural problems and function in nursing home (NH) patients with dementia.
- Conditions
- Sleep Fragmentation, Behavioural and Psychiatric Symptoms of Dementia, Dementia
- Trial name
- DEMLIGHT (NCT03357328)
- Testing
- Therapy light room, Standard light
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- University of Bergen
Liver Cirrhosis
Prevelance of Fragmented QRS Complex and Prolonged QT Interval in Cirrhotic Patients
.Cardiac affection in liver cirrhosis is a clinical condition characterized by impaired diastolic relaxation and contractility with electrophysiological abnormalities.
- Trial name
- NCT03158701
- Volunteers
- 100 people
- Sponsor
- Assiut University
Apnea, Restless Legs Syndrome
Validation Study for an Unobtrusive Online Sleep Measurement System
The purpose of the study is to determine the precision of an unobtrusive sleep measurement system. The system measures a force sensor signal under the mattress and analyzes sleep quality.
- Conditions
- Apnea, Restless Legs Syndrome, Sleep Fragmentation
- Trial name
- NCT01633151
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beddit.com Ltd
Depression, Sleep
The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression
The aim of this trial is to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression.
- Conditions
- Depression, Sleep, Sleep Disorder, Sleep Disturbance
- Trial name
- EASED (NCT03673397)
- Testing
- Aerobic exercise, bicycle ergometer
- Where
- Switzerland
- Volunteers
- 92 people
- Sponsor
- Oberwaid AG
Snoring, Sleep Fragmentation
Improving Sleep Quality During Pregnancy Using an Oral Appliance
Many pregnant women suffer from poor sleep quality and snoring. Evidence shows an increasing association between (1) sleep disordered breathing and (2) maternal cardiovascular disease and in-hospital death.
- Trial name
- PREGNCCT (NCT03646214)
- Testing
- Midline traction oral appliance
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Primary Insomnia
Sleep Laboratory Study to Investigate the Safety and Efficacy of Neu-P11 in Primary Insomnia Patients
This is a phase II study. It is conducted using a randomized, double-blind, 3-arm placebo controlled, parallel group design. Eligible patients will be randomized in a 1:1:1 ratio to receive Neu-P11 20 mg, Neu-P11 50 mg or placebo…
- Trial name
- NCT01489969
- Testing
- Neu-P11
- Where
- 9 sites in United States
- Volunteers
- 137 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Sleep Deprivation, Sleep Fragmentation
Understanding Sleep in Hospitalized Older Patients
The overall goal of this research is to elucidate how environmental, healthcare, and patient-level factors and patients' level of perceived control impact sleep duration and quality in hospitalized older patients and to assess…
- Trial name
- NCT01057823
- Where
- United States
- Volunteers
- 771 people
- Sponsor
- University of Chicago
Insomnia, Sleep Fragmentation
Suvorexant and Sleep/Delirium in ICU Patients
Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering in the cardiac intensive care unit…
- Conditions
- Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
- Trial name
- NCT04092894
- Testing
- Suvorexant 20 mg
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Beth Israel Deaconess Medical Center
White Noise, Sleep
Sleepless at Scripps: An Inpatient White Noise Study
Sleep is an important part of the healing process, and patients admitted to the hospital often report poor sleep. Patients have difficulty not only falling sleep, but also staying asleep.
- Conditions
- White Noise, Sleep, Sleep Fragmentation, Sleep Duration
- Trial name
- NCT05475262
- Testing
- Active white noise, Inactive white noise
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Scripps Health
Chronic Obstructive Pulmonary Disease
Effects of an Air Purifying Device (PureNight) on Sleep Quality in Obstructive Lung Disease
Many individuals with chronic lung disease have night time symptoms that disrupt their sleep. The purpose of this study is to determine the effects of an air purifying device (PureNight, Halo Innovations, Minneapolis, MN) on…
- Trial name
- NCT01772342
- Testing
- HEPA filtration
- Volunteers
- 50 people
- Sponsor
- VA New York Harbor Healthcare System
Cataract
Prospective Clinical Trial of the LensAR Laser System
The LensAR Laser System is used to create an opening in the anterior capsule of the lens and fragments the cataractous lens. The study will evaluate clinical outcomes compared to the contra-lateral eye treated with conventional…
- Trial name
- NCT01014702
- Testing
- LensAR Laser System, Conventional phacoemulsification
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- LensAR Incorporated
Gestational Diabetes, Gestational Diabetes Mellitus in Pregnancy
Clinic to Community Connections - Broader Distribution
This study addresses education needs in gestational diabetes care and followup at the staff and patient levels. In the initial phase, nurses and community health workers will complete specific training modules on gestational…
- Trial name
- NCT04474795
- Testing
- Staff -Educational training
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine