Clinical trials: System Lupus Erythematosus
Systemic Lupus Erythematosus
Highly Sensitive Serum Cardiac Troponin T and Cardiovascular Events in Patients With Systemic Lupus Erythematosus
Identification of biological markers able to better stratify cardiovascular risks in systemic lupus erythematosus patients is needed.
- Trial name
- TROPOPLUS (NCT04580108)
- Where
- France
- Volunteers
- 446 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Systemic Lupus Erythematosus (SLE)
Pilot Study to Assess Flares Following Inactivated Influenza Vaccine in Children With Systemic Lupus Erythematosus (SLE)
This is an open label, pilot, observational, prospective study of the safety of inactivated influenza vaccine (IIV) in children with systemic lupus erythematosus (SLE) to be conducted during the 2013-2014 influenza season.
- Trial name
- NCT02006784
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Vanderbilt University
Lupus Nephritis
Daratumumab to Treat Active Lupus Nephritis
The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in patients with active lupus nephritis.
- Trial name
- NCT04868838
- Testing
- Daratumumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Lupus Nephritis
A Study of ANX009 in Adult Participants With Lupus Nephritis
The main purpose of this study is to determine the safety and tolerability of repeat doses of ANX009 in participants with lupus nephritis (LN).
- Trial name
- NCT05780515
- Testing
- ANX009
- Where
- 7 sites in Philippines, Taiwan
- Volunteers
- 7 people
- Sponsor
- Annexon, Inc.
Systemic Lupus Erythematosus, Lupus Nephritis
Therapeutic Drug Monitoring of Mycophenolate Mofetil in Lupus Nephritis
Systemic lupus erythematosus (SLE) is an inflammatory, chronic, and multisystem autoimmune disease characterized by periods of activity and remission.
- Conditions
- Systemic Lupus Erythematosus, Lupus Nephritis, Drug Monitoring, Mycophenolic Acid
- Trial name
- LUPUS-MONITOR (NCT07493655)
- Testing
- Therapeutic Drug Monitoring, Standard clinical care
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of Maranhao
Systemic Lupus Erythematosus
Prediction of Outcome of Lupus Nephritis
The purpose of this study is to clarify the mechanisms involved in the formation and glomerular deposition of immune complexes in lupus nephritis.
- Trial name
- NCT02403115
- Testing
- Serum collection
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Istituto Giannina Gaslini
Systemic Sclerosis, Other Connective Tissue Disease
Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis
Systemic SClerosis (SSC) is a systemic disease characterized by limited or diffuse cutaneous sclerosis, microangiopathy, overproduction of autoantibodies and variable organ damage due to vasculopathy and/or fibrosis.
- Conditions
- Systemic Sclerosis, Other Connective Tissue Disease, Systemic Lupus Erythematosus, Dermatomyositis
- Trial name
- NETOSE (NCT06462768)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Psychological
Mindfulness- Based Intervention for Systemic Lupus Erythematosus (SLE) Patients
Systemic lupus erythematosus (SLE) is a rheumatic autoimmune disease, involving chronic pain, fatigue, movement difficulties, and is often accompanied by tremendous psychological and psychiatric difficulties.
- Trial name
- NCT04305418
- Testing
- Mindfulness- Based Intervention
- Where
- 2 sites in Israel
- Volunteers
- 26 people
- Sponsor
- Bar-Ilan University, Israel
Systemic Lupus Erythematosus, Systemic Scleroderma
Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies
Autoimmune diseases (AID), whether systemic or organ-specific, affect approximately one in ten people, and their prevalence continues to increase.
- Conditions
- Systemic Lupus Erythematosus, Systemic Scleroderma, ANCA-associated Vasculitis, Antiphospholipid Syndrome
- Trial name
- AutoB-Tetramer (NCT07251179)
- Testing
- blood draw
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Systemic Lupus Erythematosus of Childhood
Interferon Pathway Activation in Monogenic and Nonmonogenic Forms of Pediatric SLE
Pediatric SLE includes monogenic forms, some of which involve the interferon type I (IFN-I) pathway. The IFN-I pathway is renally active in adult SLE and correlates with the extent of renal damage.
- Trial name
- NCT06586710
- Testing
- Assessment activation of interferon pathway
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Meyer Children's Hospital IRCCS
Systemic Lupus Erythematosus, Connective Tissue Disease
A Study of LY2127399 in Participants With Systemic Lupus Erythematosus
The purpose of this SLE study is to evaluate the efficacy, safety and tolerability of two different doses of LY2127399 administered in participants with active SLE.
- Conditions
- Systemic Lupus Erythematosus, Connective Tissue Disease, Autoimmune Disease
- Trial name
- NCT01196091
- Testing
- LY2127399, Standard of Care
- Where
- 192 sites in United States, Argentina and 21 more
- Volunteers
- 1,164 people
- Sponsor
- Eli Lilly and Company
Osteoporosis, Juvenile Rheumatoid Arthritis
Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders
The purpose of this study is to evaluate denosumab as a novel treatment for bone loss in children treated with glucocorticoids for rheumatic disorders.
- Conditions
- Osteoporosis, Juvenile Rheumatoid Arthritis, Dermatomyositis, Polyarthritis
- Trial name
- NCT02418273
- Testing
- denosumab
- Where
- United States
- Sponsor
- Indiana University
Systemic Lupus Erythematosus
A Study of ICP-022 in Patients With Systemic Lupus Erythematosus (SLE)
The purpose of the study is to assess the Safety, Tolerability, PK/PD and preliminary Efficacy of ICP-022 in Subjects with Systemic Lupus Erythematosus (SLE)
- Trial name
- NCT04305197
- Testing
- ICP-022
- Where
- 11 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Lupus Nephritis
A Prospective Observational Registry of Patients Treated With LUPKYNIS® (Voclosporin) in the US
This registry is an observational study designed to assess the utilization and effectiveness of LUPKYNIS in adult patients with lupus nephritis (LN) in the United States (US).
- Trial name
- ENLIGHT-LN (NCT05337124)
- Testing
- LUPKYNIS
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Systemic Lupus Erythematosus, Antiphospholipid Syndrome
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)
The PROMISSE Study is an observational study of 700 pregnant patients, enrolled at nine major clinical centers. The purpose of the study is 1) to determine whether certain proteins (called complement split products) that can…
- Trial name
- PROMISSE (NCT00198068)
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Systemic Lupus Erythematosus
Open Label Extension Study of Epratuzumab in Japanese Systemic Lupus Erythematosus (SLE) Subjects
The study is an open-labeled extension study to continue to assess the safety and tolerability of Epratuzumab in moderate to severe SLE subjects who have previously participated in SL0026 [NCT01449071] phase I/II trial.
- Trial name
- NCT01534403
- Testing
- Epratuzumab
- Where
- 6 sites in Japan
- Volunteers
- 17 people
- Sponsor
- UCB Pharma
Systemic Lupus Erythematosus, Renal Disease
Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique
Chlordecone, an organochlorine pesticide, was widely used on banana farms in the French West Indies. Studies by Inserm and health authorities have confirmed the contamination of the food chain and the majority of the population…
- Trial name
- LUNEK (NCT06365359)
- Testing
- Blood sample for analysis of plasma of organochlorine pesticides concentration, Blood sample for cell collection
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital Center of Martinique
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus and Accelerated Aging
The study aims at evaluating the phenomena of immune system aging in patients with Systemic lupus erythematosus.
- Trial name
- LUPAGE (NCT05698173)
- Testing
- blood sample
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis (MS), Myasthenia Gravis (MG)
A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy
This is an investigator-initiated, single-center, open-label study of C-CAR168, an autologous bi-specific CAR-T therapy targeting CD20 and BCMA, for the treatment of adult patients with autoimmune diseases refractory to standard…
- Conditions
- Multiple Sclerosis (MS), Myasthenia Gravis (MG), Neuromyelitis Optica Spectrum Disorder, Systemic Lupus Erythematosus
- Trial name
- NCT07676266
- Testing
- CD20/BCMA-directed CAR-T cells Autologous 2nd generation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Systemic Lupus Erythematosus
A Study to Estimate the Relative Bioavailability, Tolerability and Safety of a Single Dose of Belimumab Self-Administered Subcutaneously (SC) by Healthy Subjects
This will be a randomized, parallel-group, open-label, single-dose study of belimumab in healthy subjects to estimate the relative bioavailability, tolerability and safety of a single dose of belimumab 200 milligram (mg) when…
- Trial name
- NCT01894360
- Testing
- Belimumab 200 mg/mL
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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