Clinical trials: System Lupus Erythematosus
Systemic Lupus Erythematosus
Respiratory Function, Physical Activity and Fatigue in SLE
Increasing awareness of possible pulmonary involvement in patients with systemic lupus erythematosus (SLE) will enable earlier diagnosis of the disease and minimize damage accumulation.
- Trial name
- NCT07193745
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Melis Usul
Nephrotic Syndrome, Systemic Lupus Erythematosus
Drug Therapy in Lupus Nephropathy
Studies have shown that up to 26% of patients with systemic lupus erythematoses nephritis may suffer from membranous lupus nephropathy.
- Trial name
- NCT00001212
- Testing
- prednisone, cyclophosphamide, cyclosporin A
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism
Autoimmune diseases are the consequence of an abnormality of the immune system, leading it to attack components of our own body. They have a wide variety of presentations.
- Conditions
- Arthritis, Rheumatoid, Spondylitis, Ankylosing, Lupus Erythematosus, Systemic, Scleroderma, Systemic
- Trial name
- MARIGYN (NCT05961267)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 318 people
- Sponsor
- University Hospital, Bordeaux
Immune System Diseases, Autoimmune Diseases
Safety Study of CDP7657 in Patients With Systemic Lupus Erythematosus
To evaluate safety, tolerability pharmacokinetics and immunogenicity of CDP7657.
- Conditions
- Immune System Diseases, Autoimmune Diseases, Lupus Erythematosus, Systemic, Skin and Connective Tissue Diseases
- Trial name
- NCT01764594
- Testing
- CDP7657
- Where
- 21 sites in Belgium, Bulgaria and 5 more
- Volunteers
- 24 people
- Sponsor
- UCB Pharma
Lupus Nephritis, Type 1 Diabetes Mellitus
Autologous Adoptive T Regulatory Cell Transfer in Autoimmune Diseases.
Investigators aim to develop an effective and safe treatment of autoimmune diseases through adoptive T regulatory cells transfer.
- Trial name
- NCT05566977
- Testing
- autologous adoptive T regulatory cell transfer.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Systemic Lupus Erythematosus (SLE)
miR-101-3p and Autotaxin in SLE Patients
Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs and characterized by heterogeneous clinical manifestations.
- Trial name
- NCT07252141
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eman Mohamed Shawky
Systemic Lupus Erythematosus
A Two-part Study to Investigate the Interaction and Pharmacokinetics of GSK2586184
This study is a Phase I, two-part, open-label study designed to evaluate the effect of repeated doses of GSK2586184 on the pharmacokinetics (PK) of Simvastatin and Rosuvastatin in healthy volunteers (Cohort A), and to evaluate…
- Trial name
- NCT01953835
- Testing
- GSK2586184 standard formulation, Simvastatin, Rosuvastatin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lupus Nephritis
Renal Arterial Resistive Index as a Noninvasive Biomarker of Disease Activity in Lupus Nephritis Patients
Systemic Lupus Erthymatosous (SLE) is achronic inflammatory multi system auto immue disease characterized by pathogenic auto anti bodies production against nuclear structures (Bolouri et al.,2022), SLE affecting mainly woemn of…
- Trial name
- NCT06631404
- Testing
- renal doppler
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Sohag University
Systemic Lupus Erythematosus
Lupus Arthritis: Muscoloskeletal Ultrasound as Clinical Outcome of Peripheral Blood and Synovial Deep Phenotyping
Musculoskeletal involvement, defined as arthritis/arthralgia, is the most common manifestation of patients with systemic lupus erythematosus (SLE).
- Trial name
- LUMAPS (NCT07102238)
- Testing
- muscoloskeletal ultrasound and synovial biopsy
- Where
- Italy
- Volunteers
- 269 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Systemic Lupus Erythematosus
Regulatory BCells in Systemic Lupus Erythematosus
Systemic lupus erythematosus , the archetypal multisystem autoimmune disease, presents many diagnostic and management challenges.
- Trial name
- NCT03178721
- Testing
- blood sample
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mycophenolate Mofetil, Cyclophosphamide
MMF Versus CYC in the Induction Therapy of Pediatric Active Proliferative LN
A prospective, randomized, multicenter, open-label, parallel-arm Study to compare effectiveness of mycophenolate mofetil versus cyclophosphamide in the Induction Therapy of pediatric patients with Active Proliferative Lupus…
- Conditions
- Mycophenolate Mofetil, Cyclophosphamide, Lupus Nephritis
- Trial name
- MyCITS (NCT05495893)
- Testing
- Cyclophosphamide, Mycophenolate Mofetil
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Second Xiangya Hospital of Central South University
Systemic Lupus Erythematosus
Study of Daxdilimab (HZN-7734) for the Treatment of Systemic Lupus Erythematosus in an Open-label Extension Study
A Phase 2, Open-Label Extension study to evaluate the long-term safety and tolerability of daxdilimab in participants with Systemic Lupus Erythematosus completing the treatment period of the RECAST SLE clinical study.
- Trial name
- RECAST SLE OLE (NCT05430854)
- Testing
- Daxdilimab
- Where
- 52 sites in United States, Argentina and 7 more
- Volunteers
- 155 people
- Sponsor
- Amgen
Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome
The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refractory Autoimmune Diseases
This is an investigator-initiated trial to evaluate the safety and efficacy of anti- CD19-CAR-T cells in the relapse or refractory autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome, Systemic Sclerosis, Inflammatory Myopathy
- Trial name
- NCT06420154
- Testing
- anti-CD19-CAR-T cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
SLE
New Signaling Pathway Targeting Systemic Lupus Erythematosus
Systemic lupus erythematosus is inflammatory autoimmune disease that affects over one million people in the United States. It has a higher prevalence and incidence rate among women compared with men, and among African Americans…
- Trial name
- NCT03984227
- Testing
- Taking peripheral blood samples
- Volunteers
- 60 people
- Sponsor
- Assiut University
Systemic Lupus Erythematosus
Walk With Ease Program For Patients With Systemic Lupus Erythematosus
The purpose of this study is to evaluate the effects of "Walk With Ease", a moderate-intensity exercise program, on pain, stiffness, and fatigue caused by lupus. Participants will receive a copy of the "Walk With Ease" workbook.
- Trial name
- Walk SLE (NCT02631005)
- Testing
- "Walk With Ease"
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of North Carolina, Chapel Hill
Systemic Lupus Erythematosus
PRediction Of Flares In Lupus With autoantibodiEs and Chemokines
Rationale: Systemic lupus erythematosus (SLE) is a chronic relapsing-remitting autoimmune disease with a wide range of clinical manifestations affecting several organs.
- Trial name
- PROFILE (NCT04951427)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Systemic Lupus Erythematosus
Study of Epratuzumab in Systemic Lupus Erythematosus (SLE)
The purpose of this study is to evaluate the safety and efficacy of Epratuzumab with standard treatments for patients with SLE.
- Trial name
- NCT00383214
- Testing
- Epratuzumab
- Where
- 60 sites in United States, Belgium and 9 more
- Volunteers
- 54 people
- Sponsor
- UCB Pharma
Healthy Volunteers, Systemic Lupus Erythematosus (SLE)
A Study of KK4277 in Healthy Volunteers and Patients With Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus
Part 1 : To evaluate the safety and tolerability of a single intravenous (IV) or subcutaneous (SC) dose of KK4277 in healthy Japanese or non-Asian adult males.
- Conditions
- Healthy Volunteers, Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE)
- Trial name
- NCT05411016
- Testing
- KK4277
- Where
- 23 sites in Japan, South Korea
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
Early Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases
Main purpose: To evaluate the safety of UTAA09 injection in the treatment of relapsed/refractory (R/R) autoimmune disease (AID).
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, IgG4 Related Disease
- Trial name
- NCT06361745
- Testing
- T cell injection targeting CD19 chimeric antigen receptor
- Where
- China
- Volunteers
- 10 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Systemic Lupus Erythematosus, Periodontitis
Treatment of Periodontal Disease in Systemic Lupus Erythematosus
The primary objective of this study is to: Part 1 - Baseline Comparisons The primary objective of Part 1 is to: Investigate the association between SLE and a measures of vascular health (brachial artery flow-mediated dilatyation)…
- Trial name
- NCT04046172
- Testing
- supra/sub gingival root surface debridement, supra-gingival scaling and polishing
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
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