Clinical trials: System Sclerosis
Secondary-progressive Multiple Sclerosis
Study to Assess the Efficacy of Mayzent on Microglia in Secondary Progressive Multiple Sclerosis
To assess the efficacy of Mayzent on microglia pathology in patients with active SPMS, as compared to the active control group of MS patients treated with the Ocrevus, as measured by changes in microglial activation in the…
- Trial name
- NCT04925557
- Testing
- Mayzent, Ocrevus
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- State University of New York at Buffalo
Multiple Sclerosis
Life-Style Exercise and Activity Package for People Living With Progressive MS
The investigators know that many people with multiple sclerosis (MS) require support to remain physically active and often do not receive any or enough support.
- Trial name
- LEAP-MS (NCT03951181)
- Testing
- LEAP-MS
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Cardiff University
Amyotrophic Lateral Sclerosis
Safety and Tolerability of the Ketogenic Diet in Amyotrophic Lateral Sclerosis (ALS)
This research is being done to see if the ketogenic diet (which is high in fat and low in carbohydrates) is safe and tolerable in amyotrophic lateral sclerosis (ALS) patients who are fed through a gastrostomy tube.
- Trial name
- NCT01016522
- Testing
- KetoCal
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
A Study to Evaluate the Preliminary Efficacy Pharmacokinetics and Immunogenicity of BMS-188667 Administered to Subjects With Relapsing-remitting Multiple Sclerosis
The purpose of this study is to determine whether BMS-188667 will decrease multiple sclerosis disease activity on MRI examinations, as well as decrease the rate of clinical MS exacerbations, compared to placebo
- Trial name
- NCT00035529
- Testing
- BMS 188667 (Abatacept)
- Where
- 10 sites in United States
- Sponsor
- Bristol-Myers Squibb
Amyotrophic Lateral Sclerosis, ALS
Study of miRNA Expression Pattern as Diagnostic and Prognostic Biomarker in Amyotrophic Lateral Sclerosis
The principal goal is to demonstrate that a specific pattern of microRNA (miRNA) expression can be correlated with the definite diagnostic of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- MIRSLA (NCT01992029)
- Testing
- Clinical evaluation, Muscular biopsy, Lumbar puncture
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
A Measurement Study of TIS-modNV and AccuGait Force Platform in People With MS
The current project will fill a knowledge gap in the follow-up of people with Multiple Sclerosis (MS) with mild and moderate disability levels, with the purpose to assess the adequacy of measurement tools for trunk control and…
- Trial name
- NCT05503628
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Nordlandssykehuset HF
Multiple Sclerosis
Thermal Cures in the Treatment of Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic, progressive disease with a high prevalence in France, with significant public health consequences.
- Trial name
- SPA-SEP (NCT03915028)
- Testing
- Spa therapy
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Association Francaise pour la Recherche Thermale
Amyotrophic Lateral Sclerosis
Effects of ODM-109 on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis
In the double-blind, cross-over part of the study, ODM-109 capsules and placebo capsules for ODM-109 will be administered for 2 weeks separated by a 19-23 days wash-out period.
- Trial name
- ALS (NCT02487407)
- Testing
- ODM-109
- Where
- 11 sites in Germany, Ireland and 2 more
- Volunteers
- 66 people
- Sponsor
- Orion Corporation, Orion Pharma
Scleroderma, Autoimmune Diseases
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma
- Trial name
- NCT05085444
- Testing
- Assigned Interventions CD19/BCMA CAR T-cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Tuberous Sclerosis Complex
Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex
Study design is a Phase IIb prospective multi-center, randomized, placebo-controlled, double-blind clinical trial. The goal will be to enroll 80 infants with Tuberous Sclerosis Complex who are less than 6 months of age prior to…
- Trial name
- NCT02849457
- Testing
- Early Vigabatrin
- Where
- 13 sites in United States
- Volunteers
- 84 people
- Sponsor
- Martina Bebin
Systemic Sclerosis
PET Imaging of Systemic Sclerosis Using FDG and 68Ga-DOTA-Siglec-9
This study evaluates the potential of positron emission tomography (PET)/computed tomography (CT) imaging to monitor disease activity in patients with systemic sclerosis (SSc).
- Trial name
- SYSPET (NCT05108857)
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital
Sclerosis, Multiple, Cognitive Dysfunction
XO as a Screening Test of Cognitive Impairment in Multiple Sclerosis
Even at the disease onset, about 70% of patients with multiple sclerosis (MS) suffer from cognitive impairment that impacts quality of life.
- Trial name
- XO-SEP (NCT03999034)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Multiple Sclerosis
At-Home Gait Assessment
The goal of this study is to validate an MS Gait Remote Capture and Analysis (MS-GRCA) system based on wearable shoe-based motion sensors for home-based and repeatable gait assessments.
- Trial name
- NCT05724901
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Multiple Sclerosis
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
The investigators want to evaluate ovarian reserve concerning patients with multiple sclerosis, compared to a control group of healthy women. This study will include women from 25 to 35 years old.
- Trial name
- FEMINISEP (NCT05754593)
- Testing
- Anti-Mullerian hormone (AMH) level, Antral follicle count (AFC), Clinical assessment
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility
Background: Research shows that both genes and the environment influence a person s risk for getting multiple sclerosis (MS). However, it is not possible to accurately predict who will develop MS.
- Trial name
- NCT01617395
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Scleroderma
Safety Evaluation of Dasatinib in Subjects With Scleroderma Pulmonary Fibrosis
The purpose of this study was to evaluate the safety of Dasatininb in the treatment of scleroderma pulmonary interstitial fibrosis.
- Trial name
- NCT00764309
- Testing
- dasatinib
- Where
- 13 sites in United States
- Volunteers
- 47 people
- Sponsor
- Bristol-Myers Squibb
Multiple Sclerosis
Safety and Tolerability of Interferon-Beta-1a and Estroprogestins Association in MS Patients
Clinical and experimental evidences suggests an immunomodulatory effect of sex hormones in multiple sclerosis. The role of oral estroprogestins in the pathogenesis and in the clinical course of the disease is actually unknown.
- Trial name
- NCT00151801
- Testing
- estroprogestins, interferon-beta 1a
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- S. Andrea Hospital
Multiple Sclerosis, Vestibular
The Effects of Vestibular Exercise and Cervical Stabilization Exercise Training on Balance and Gait in MS Patients
The population of this research consists of individuals between the ages of 18-65 with MS disease. MS patients to be included in the study will be directed by the Neurology outpatient clinic of Sanko University Hospital.
- Conditions
- Multiple Sclerosis, Vestibular, Exercises
- Trial name
- NCT05409599
- Testing
- Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Sanko University
Multiple Sclerosis (MS) - Relapsing-remitting
Exploration of Novel Imaging Biomarkers on OCT for Ublituximab Treatment Response in Multiple Sclerosis
The purpose of the research study is to explore new retinal imaging biomarkers of immune cell activity in MS during use of ublituximab (Briumvi) treatment.
- Trial name
- NCT06864936
- Testing
- Ublituximab, Other disease modifying therapies
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Multiple Sclerosis
Study of Social Cognition by Morphological and Functional Imaging in Multiple Sclerosis Patients
In recent years, studies have brought knowledge of the difficulties of social cognition in Multiple Sclerosis (MS). The brain tissue alteration at the origin of these difficulties in social cognition mechanisms remain poorly…
- Trial name
- SOCOG-MS (NCT02290587)
- Testing
- Brain MRI - Clinical and cognitive evaluation, MRI
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
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