Clinical trials: System Sclerosis
Amyotrophic Lateral Sclerosis
Online Self-Compassion Course for pALS (Compassion pALS)
This study is designed to be a pragmatic, single-arm trial to evaluate the efficacy, implementation, and feasibility of an online ALS-specific self-compassion training program to enhance self-compassion and improve quality of…
- Trial name
- NCT05202743
- Testing
- Observational for ALS patients
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Walk With Me: a Mobile Application to Improve Walking in Persons With MS
During 10 weeks the subjects will use a mobile application (Walk with Me). The aim of this study is to investigate the usability of the mobile application, as well as investigating if the mobile application effects walking.
- Trial name
- NCT04142008
- Testing
- Walk with Me app
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- Hasselt University
Scleroderma
UVA-1 for Treatment of Skin Tightening and Improvement of Hand Function in Scleroderma
UVA-1 has been reported to be beneficial to skin changes in scleroderma in several case reports and a few small studies. (Jacobe 2020) Interpretation of these reports has been difficult based on the small numbers of subjects…
- Trial name
- NCT04875078
- Testing
- UVA-1 Phototherapy, UV-Blocking Glove
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Utah
Tuberous Sclerosis Complex
Clinical Study of NPC-12Y Gel in Patients With Skin Lesions Associated With TSC
The purpose of this study is to investigate the efficacy and safety of NPC-12Y gel compared with placebo for skin lesions associated with tuberous sclerosis.
- Trial name
- NCT05495425
- Testing
- NPC-12Y gel
- Where
- 5 sites in Japan
- Volunteers
- 43 people
- Sponsor
- Nobelpharma
Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc)
Correlation Between Circulating Fibroblast Activation Protein (FAP) and Fibrosis in Two Diseases (Rheumatoid Arthritis and Systemic Sclerosis)
This study aims to measure a blood protein called fibroblast activation protein (FAP), which is linked to tissue scarring and inflammation.
- Trial name
- FAP (NCT07393217)
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Sohag University
Amyotrophic Lateral Sclerosis
Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis
In this proposed study, the investigators will evaluate the safety and efficacy of lipoic acid in treatment of Amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT04518540
- Testing
- lipoic acid group, control group
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multiple Sclerosis
Virtual Reality in Physical Therapy in Multiple Sclerosis
The randomized controlled trial is aimed to study the efficacy of virtual reality (VR) and its impact on upper limb function and postural stability in people with mild to severe multiple sclerosis (pwMS).
- Trial name
- VIREMS (NCT04807738)
- Testing
- Neuroproprioceptive "facilitation and inhibition" in virtual reality, Neuroproprioceptive "facilitation and inhibition"
- Where
- 2 sites in Czechia
- Volunteers
- 71 people
- Sponsor
- Charles University, Czech Republic
Pre-Pulmonary Atrial Hypertension
Ambrisentan for the Improvement in Right Ventricular Strain in Scleroderma Associated Pulmonary Arterial Hypertension
This research study is looking at the use of the drug ambrisentan and if it can improve right ventricle function in people with systemic sclerosis-associated pre-pulmonary arterial hypertension.
- Trial name
- AMERICA-PAH (NCT02169752)
- Testing
- Ambrisentan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Jewish Health
Multiple Sclerosis, Chronic Progressive
China Betaferon Adherence, Coping and Nurse Support Study
Non-adherence reduces treatment benefit and can bias the assessment of treatment efficacy thereby involving safety risks for the patient and influencing health cost-effectiveness.
- Trial name
- NCT01436838
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Bayer
SYSTEMIC SCLERODERMA
Cyclophosphamide and rATG With Hematopoietic Stem Cell Support in Systemic Scleroderma
Scleroderma is a systemic disorder categorized as an immunologically mediated disease that causes collagen deposition of skin and visceral organs.
- Trial name
- NCT00278525
- Testing
- standard of care, stem cell transplantation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Multiple Sclerosis, Respiration Disorders
Description Des Troubles Respiratoires Chez Les Patients Suivis Pour Une Sclérose en Plaques (SEP) sévère
The purpose of this study is to describe respiratory disorders in patients with severe multiple sclerosis (EDSS from 6.5).
- Trial name
- RespiMuS (NCT03339817)
- Testing
- Polysomnography
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Systemic Sclerosis, Diaphragm Defect
Muscular Respiratory Involvement and Systemic Sclerosis
Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors.
- Conditions
- Systemic Sclerosis, Diaphragm Defect, Respiratory Insufficiency, Pulmonary Function Test
- Trial name
- SIROCO (NCT04118725)
- Testing
- Pulmonary function test
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Poitiers University Hospital
Systemic Sclerosis
Lysyl Oxidase, Semaphorin 7a and Semaphorin 3a in Patients With Systemic Sclerosis
The aim of our study is to find a biomarker for fibrosis or vasculopathy in systemic sclerosis. We will evaluate a possible correlation between semaphorin 7a, semaphorin 3a and lysyl oxidase and fibrosis (lung and skin) or…
- Trial name
- NCT01943968
- Testing
- Blood test
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hillel Yaffe Medical Center
Neurogenic Dysphonia, Neurogenic Dysphagia
Neurogenic Dysphonia/Dysphagia Registry
The Neurogenic Dysphonia/Dysphagia Registry is designed to be purely observational (i.e. non-interventional, exploratory). Patient data collected from the registry is expected to be consistent with any information which can be…
- Trial name
- StrongVoice (NCT02493491)
- Where
- 12 sites in United States
- Volunteers
- 146 people
- Sponsor
- Merz North America, Inc.
Multiple Sclerosis
Investigation of the Effect of Ocrelizumab on Peripheral Lymphocyte Immunophenotypes with Suppressive Capacity in MS
This is a 24-month, prospective, exploratory, observational study to investigate immune phenotypes in patients with MS following treatment with ocrelizumab.
- Trial name
- NCT04874597
- Testing
- Ocrelizumab
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr Recai Turkoglu
Multiple Sclerosis
Consolidation Therapy With Cladribine in Relapsing Multiple Sclerosis Patients
To investigate the impact on IgG and IgM concentration, infection risk and effectiveness of switching from anti-CD20 to cladribine compared to continued anti-CD20 treatment over 2 years in relapsing MS patients.
- Trial name
- OCR_CLAD (NCT06854094)
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Amyotrophic Lateral Sclerosis
Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype
The main objective of this study is to investigate the correlation between the rate of motor decline and blood levels of Vitamin D total.
- Trial name
- NCT01823380
- Testing
- Blood test
- Where
- France
- Volunteers
- 127 people
- Sponsor
- University Hospital, Montpellier
Multiple Sclerosis, Pregnancy
Fampridine Pregnancy Exposure Registry
This is a global pregnancy registry to evaluate the outcomes of pregnancy in women with multiple sclerosis who have been exposed to prolonged-release fampridine since the first day of their last menstrual period prior to…
- Trial name
- NCT01532154
- Testing
- Fampridine
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Biogen
Multiple Sclerosis, Encephalitis
tDCS and Cognition in Adults With Multiple Sclerosis or Encephalitis
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities in individuals with multiple sclerosis (MS) or encephalitis.
- Trial name
- NCT02538094
- Testing
- Anodal Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Primary Progressive Multiple Sclerosis
Tear Analysis in the Diagnosis of Multiple Sclerosis
In the primary progressive multiple sclerosis, the detection of oligoclonal bands in cerebrospinal fluid is critical for the diagnosis.
- Trial name
- LARMES (NCT02016222)
- Testing
- tears sampling
- Where
- 13 sites in France
- Volunteers
- 80 people
- Sponsor
- Lille Catholic University
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.